Association between <em>CD14 </em>rs2569190 C&gt;T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects

Abstract

IntroductionPrevious epidemiological studies have suggested that CD14 rs2569190 C>T polymorphism plays an important role in ischemic stroke (IS) risk, but the results were inconsistent. Therefore, we conducted a meta-analysis to determine the association between CD14 rs2569190 C>T polymorphism and IS susceptibility.MethodsOnline databases were searched from inception up to July 1, 2018, for studies concerning CD14 rs2569190 C>T polymorphism and its association with IS susceptibility. ORs and corresponding 95% CIs were calculated in the genetic models of each polymorphism locus with Stata Version 14.0. Furthermore, heterogeneity, meta-regression, accumulative analyses, sensitivity analyses, and publication bias were examined.ResultsOverall, 10 observed studies involving 5,277 subjects were included in this meta-analysis on CD14 rs2569190 C>T polymorphism. Generally, no significant associations were found between CD14 rs2569190 C>T polymorphism and IS risk (allele contrast of T vs C: OR =1.03, 95% CI =0.96–1.12, P=0.41, I2=27.8%; co-dominant models of CT vs CC: OR =1.01, 95% CI =0.81–1.25, P=0.95, I2=51.9%; co-dominant models of TT vs CC: OR =1.04, 95% CI =0.89–1.22, P=0.62, I2=25.1%; dominant model of CT + TT vs CC: OR =1.02, 95% CI =0.84–1.25, P=0.82, I2=51.4%; recessive model of TT vs CC + CT: OR =1.07, 95% CI =0.95–1.22, P=0.28, I2=0%), similar to the results in the subgroup analysis.ConclusionThe current evidence indicated that CD14 rs2569190 C>T polymorphism was not a critical risk factor for IS development.

The Influence of Single Nucleotide Polymorphisms of NOD2 or CD14 on Susceptibility to Tuberculosis: A Systematic Review

“…IFN-γ is an essential cytokine for the control of mycobacterial infection [36], and for that reason it is possible to hypothesize that rs2569190 may result in an environment that favors development of TB. Interestingly, other studies also related this SNP with occurrence of ischemic stroke [37], cardiovascular disease [38] and asthma [39], indicating that these polymorphisms could actually lead to a more profound alteration in immune responses that may affect a large number of clinical conditions.…”

The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review

“…IFN-γ is an essential cytokine for the control of mycobacterial infection [ 39 ], and therefore, rs2569190 may produce an environment that favors development of TB. Interestingly, other studies found this SNP associated with ischemic stroke [ 40 ], cardiovascular disease [ 41 ], and asthma [ 42 ], indicating that these polymorphisms could actually lead to a more profound alteration in immune responses that may affect a large number of clinical conditions.…”