Increased risk of hypercholesterolemia in a French and Lebanese population due to an interaction between rs2569190 in CD14 and gender

Shamieh, Said El; Salami, Ali; Stathopoulou, Maria G.; Chedid, Pia; Visvikis‐Siest, Sophie

doi:10.1016/j.cca.2020.06.020

Cited by 1 publication

(1 citation statement)

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“…The current study is one of many reporting a link between components of the innate immune system and CVDs [32,33]. It is known that activated innate immune system elements and dysfunction in metabolic pathways could lead to the chronic inflammation, resulting in CVDs [32,33].…”

Section: Discussionmentioning

confidence: 93%

The Association of rs1898830 in Toll-Like Receptor 2 with Lipids and Blood Pressure

Chedid

Salami

Shamieh

2020

JCDD

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Background and Objective: Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension. Methods: A cross-sectional study was conducted on 460 individuals free from chronic diseases. Clinical and biological data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). Multiple logistic regression models, adjusted for six covariates, were used. A power calculation analysis was also performed. Results: We found that rs1898830 in TLR2 was positively associated with hypertension (OR = 2.18, p = 0.03) and negatively associated with high-density lipoprotein cholesterol (OR = 0.66, p = 0.05). In contrast, no relation was found with total cholesterol and low-density lipoprotein cholesterol. Conclusion: The present results provide additional evidence supporting the implication of TLR2 in CVD risk factors.

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