The Association of rs1898830 in Toll-Like Receptor 2 with Lipids and Blood Pressure

Abstract

<jats:p>Background and Objective: Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension. Methods: A cross-sectional study was conducted on 460 individuals free from chronic diseases. Clinical and biological data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). Multiple logistic regression models, adjusted for six covariates, were used. A power calculation analysis was also performed. Results: We found that rs1898830 in TLR2 was positively associated with hypertension (OR = 2.18, p = 0.03) and negatively associated with high-density lipoprotein cholesterol (OR = 0.66, p = 0.05). In contrast, no relation was found with total cholesterol and low-density lipoprotein cholesterol. Conclusion: The present results provide additional evidence supporting the implication of TLR2 in CVD risk factors.</jats:p>

Impact of genetic polymorphisms related to innate immune response on respiratory syncytial virus infection in children

“…Although some TLR2 polymorphisms have been associated with the severity of viral infections, the contribution or mechanism of some of them have not been clearly described yet. The polymorphism rs18998830, known as -15,607 A/G and laid on the first intron of the TLR2 gene, has been significantly associated to severe bronchiolitis induced by RSV with fatalities in the Brazilian infants [70,71]. Another polymorphism in TLR2 gene, named as rs3804099, which is a synonymous SNPs in the single exon that means a C/T change coding Asn, was associated to a reduced proinflammatory cytokine secretion in hepatitis B virus chronic infection in a Chinese population [72].…”

Study of gene polymorphisms in Toll-like receptor 2 in patients with acute lymphoblastic leukemia

“…Human TLR2 is located in the long arm of chromosome 4 (4q31.3), including one coding exon and two non-coding exons. TLR2 has been recognized as a pathogenic factor implicated in tumorigenesis [ 5 , 16 ]. We observed a combined effect of a genetic variant of TLR2 since all four SNPs, rs1898830, rs3804100, rs3804099, and rs1339, showed a significant protective association against ALL, while Individuals carrying rs1337 C > G have a higher risk of ALL in the Saudi population.…”

“…In contrast to our results, this SNP has been associated with the risk of different conditions in various populations. A study conducted in Lebanon revealed that G allele carriers were associated with decreased HDL-C levels and an increased risk of hypertension [ 16 ].…”

The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes

“…Its functional significance is still unclear. However, it has been suggested that the small G allele may alter the expression or functionality of TLR2, resulting in an increase in the number and/or function of macrophages and endothelial cells, thereby enhancing the innate immune response, which is also involved in the pathophysiology of atherosclerosis [49,50]. The association of this variant with COVID-19 has not been studied.…”