Association between lower urinary tract symptoms and cardiovascular risk scores in ostensibly healthy women

Lee, Hyun Young; Moon, Ji Eun; Sun, Hwa Yeon; Doo, Seung Whan; Yang, Won Jae; Song, Yun Seob; Lee, So‐Ryoung; Park, Byoung-Won; Kim, Jae Heon

doi:10.1111/bju.14577

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…[3][4][5] Notably, the presence of OAB is known to be a predictive factor of future cardiovascular events. 6,7 Microalbuminuria (leakage of a small amount of albumin into the urine) is deeply related to vascular endothelial dysfunction. 8 The presence of microalbuminuria is closely related to ageing, obesity, hypertension, dyslipidemia, DM, and CKD.…”

Section: Introductionmentioning

confidence: 99%

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The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

Okamoto

Andô

Jung

et al. 2020

Neurourology and Urodynamics

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Aims To investigate the longitudinal association of microalbuminuria with overactive bladder (OAB). Methods This longitudinal study investigated 561 participants of the Iwaki Health Promotion Project in both 2015 and 2019 in Japan. Microalbuminuria and OAB symptoms were assessed using the urine albuminuria creatinine ratio (ACR) and the overactive bladder symptom score (OABSS), respectively. Urine ACR was defined as high if ≥9.3 mg/gCr. Differences in OABSS between 2015 and 2019 were evaluated as ∆OABSS. Participants were divided into two groups according to ΔOABSS: high (ΔOABSS > 1) and control (≤1). We used baseline data acquired in 2015, such as urine ACR, the Pittsburgh Sleep Quality Index (PSQI), and arterial stiffness expressed by brachial‐ankle pulse wave velocity (baPWV). Predictive factors of a ΔOABSS > 1 were assessed by multivariable logistic regression analysis. Results This study included 332 women and 229 men. Of those, 86 (34 males and 52 females) were classified into the ΔOABSS > 1 group. There were significant group differences in age, renal function, and hemoglobin A1c. Participants in the ΔOABSS > 1 had a higher prevalence of PSQI > 5, baPWV ≥ 1400 seconds/cm, and urine ACR ≥ 9.3 mg/gCr (49% vs 20%, P = .001) than those in the control group. Multivariable analysis revealed that PSQI > 5 (odds ratio [OR], 2.57; 95% confidence interval [CI], 1.15‐4.60; P = .002) and urine ACR ≥ 9.3 mg/gCr (OR, 1.93; 95% CI, 1.15‐3.23; P = .013) were independent risk factors for ΔOABSS > 1. Conclusions Microalbuminuria may be an independent risk indicator for OAB symptom exacerbation.

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Section: Introductionmentioning

confidence: 99%

“…Although the exact etiologies of OAB remain unclear, one of the believed theories to describe the disease process involves ischemia, vascular damage, and endothelial dysfunction of the bladder 3‐5 . Notably, the presence of OAB is known to be a predictive factor of future cardiovascular events 6,7 …”

Section: Introductionmentioning

confidence: 99%

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

Okamoto

Andô

Jung

et al. 2020

Neurourology and Urodynamics

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“…However, our study ndings reveal a negative association between LE8 score and the risk of OAB, suggesting a potential link between better CVH and lower OAB risk. OAB, as a subset of lower urinary tract symptoms (LUTS), has been previously associated with increased cardiovascular risk scores in both males and females [29][30][31]. However, direct evidence regarding the relationship between OAB and CVH is currently lacking.…”

Section: Discussionmentioning

confidence: 99%

A negative association between the Life’s Essential 8 and overactive bladder in United States Adult

Wei,

Lin,

Zhao

et al. 2024

Preprint

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Background: Overactive bladder (OAB) significantly impacts the quality of life of affected individuals. This study aims to investigate the association between Life’s Essential 8 (LE8) and the presence of OAB among adults in the United States. Methods: We included adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. LE8 score were categorized as low (0–49), moderate (50–79), and high (80–100). We utilized multivariable logistic models and restricted cubic spline models to assess these associations. Results: A total of 25,859 participants were included, among whom 5,255 were determined to have OAB. After adjusting for potential confounders, higher LE8 score were significantly associated with a lower risk of OAB (OR 0.78; CI 95% 0.75-0.81). This relationship exhibited a negative linear dose–response pattern. Similar patterns were also identified in the association between health behavior and health factor scores with OAB. Subgroup analyses confirmed the robustness and reliability of the results. Conclusions: Our study reveals a negative linear association between LE8 and its subscale scores, and the presence of OAB risk. These findings suggest that adherence to the LE8 framework might be advantageous in reducing OAB risk.

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Cardiovascular risk independently predicts small functional bladder storage capacity

et al. 2020

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Association between lower urinary tract symptoms and cardiovascular risk scores in ostensibly healthy women

Cited by 7 publications

References 23 publications

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

A negative association between the Life’s Essential 8 and overactive bladder in United States Adult

Cardiovascular risk independently predicts small functional bladder storage capacity

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