A negative association between the Life’s Essential 8 and overactive bladder in United States Adult

Abstract

Background: Overactive bladder (OAB) significantly impacts the quality of life of affected individuals. This study aims to investigate the association between Life’s Essential 8 (LE8) and the presence of OAB among adults in the United States. Methods: We included adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. LE8 score were categorized as low (0–49), moderate (50–79), and high (80–100). We utilized multivariable logistic models and restricted cubic spline models to assess these associations. Results: A total of 25,859 participants were included, among whom 5,255 were determined to have OAB. After adjusting for potential confounders, higher LE8 score were significantly associated with a lower risk of OAB (OR 0.78; CI 95% 0.75-0.81). This relationship exhibited a negative linear dose–response pattern. Similar patterns were also identified in the association between health behavior and health factor scores with OAB. Subgroup analyses confirmed the robustness and reliability of the results. Conclusions: Our study reveals a negative linear association between LE8 and its subscale scores, and the presence of OAB risk. These findings suggest that adherence to the LE8 framework might be advantageous in reducing OAB risk.