Association between insulin-like growth factor-1 and cardiovascular disease risk: Evidence from a meta-analysis

Jing, Zhaohai; Hou, Xu; Wang, Yali; Gao, Yang; Wang, Bin; Tian, Xin; Zhao, Shihua; Wang, Yangang

doi:10.1016/j.ijcard.2015.06.114

Cited by 13 publications

(5 citation statements)

References 23 publications

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“…Recent evidence suggests that IGF1 levels are related to CVD in an U-shaped fashion, with both low and high circulating IGF1 levels being associated with an increased CVD risk (34, 35). Since the importance of inflammation in the development of CVD is well established (9, 10), we previously investigated the effects of IGF1 in vitro .…”

Section: Discussionmentioning

confidence: 99%

Persistent inflammation and endothelial dysfunction in patients with treated acromegaly

Wolters

Heijden

Leeuwen³

et al. 2019

Endocrine Connections

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ObjectiveAcromegaly is characterized by an excess of growth hormone (GH) and insulin-like growth factor 1 (IGF1). Cardiovascular disease (CVD) risk factors are common in acromegaly and often persist after treatment. Both acute and long-lasting pro-inflammatory effects have been attributed to IGF1. Therefore, we hypothesized that inflammation persists in treated acromegaly and may contribute to CVD risk.MethodsIn this cross-sectional study, we assessed cardiovascular structure and function, and inflammatory parameters in treated acromegaly patients. Immune cell populations and inflammatory markers were assessed in peripheral blood from 71 treated acromegaly patients (with controlled or uncontrolled disease) and 41 matched controls. Whole blood (WB) was stimulated with Toll-like receptor ligands. In a subgroup of 21 controls and 33 patients with controlled disease, vascular ultrasound measurements were performed.ResultsLeukocyte counts were lower in patients with controlled acromegaly compared to patients with uncontrolled acromegaly and controls. Circulating IL18 concentrations were lower in patients; concentrations of other inflammatory mediators were comparable with controls. In stimulated WB, cytokine production was skewed toward inflammation in patients, most pronounced in those with uncontrolled disease. Vascular measurements in controlled patients showed endothelial dysfunction as indicated by a lower flow-mediated dilatation/nitroglycerine-mediated dilatation ratio. Surprisingly, pulse wave analysis and pulse wave velocity, both markers of endothelial dysfunction, were lower in patients, whereas intima-media thickness did not differ.ConclusionsDespite treatment, acromegaly patients display persistent inflammatory changes and endothelial dysfunction, which may contribute to CVD risk and development of CVD.

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Section: Discussionmentioning

confidence: 99%

Persistent inflammation and endothelial dysfunction in patients with treated acromegaly

Wolters

Heijden

Leeuwen³

et al. 2019

Endocrine Connections

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“…Growth hormone deficiency (GHD)) and IGF-1 excess (e.g. acromegaly) groups [51,52], whereas decreased mortality was found for IGF-I levels between 0 and +1 SD, which is suggested to be the optimal range in adults [52].…”

Section: The Relation Between Gh/igf-1 and Cvdmentioning

confidence: 99%

Acromegaly, inflammation and cardiovascular disease: a review

Wolters¹,

Netea

Riksen³

et al. 2020

Rev Endocr Metab Disord

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Acromegaly is characterized by Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) excess. Uncontrolled acromegaly is associated with a strongly increased risk of cardiovascular disease (CVD), and numerous cardiovascular risk factors remain present after remission. GH and IGF-1 have numerous effects on the immune and cardiovascular system. Since endothelial damage and systemic inflammation are strongly linked to the development of CVD, and have been suggested to be present in both controlled as uncontrolled acromegaly, they may explain the presence of both micro- and macrovascular dysfunction in these patients. In addition, these changes seem to be only partially reversible after remission, as illustrated by the often reported presence of endothelial dysfunction and microvascular damage in controlled acromegaly. Previous studies suggest that insulin resistance, oxidative stress, and endothelial dysfunction are involved in the development of CVD in acromegaly. Not surprisingly, these processes are associated with systemic inflammation and respond to GH/IGF-1 normalizing treatment.

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“…41 IGF-1 production in response to an increased number of adipocytes may play a role in the decreased output of GH observed in patients who suffer from obesity. 20,42,43 However, this decrease in the secretion of this hormone is not associated with an alteration in the speed of growth, since obese children usually have a normal or even increased height for their age; for example, in this study, the obese group was 7cm taller than children of similar age with adequate weight.…”

Section: Discussionmentioning

confidence: 52%

Marcadores de riesgo cardiovascular en niños menores de 10 años y su relación con niveles séricos de IGF-1, IGFBP-1, IGFBP-2 e IGFBP-3

et al. 2020

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Introduction: Any type of nutritional imbalance experienced during childhood will affect the health of an individual, both in their childhood and their adulthood. Several studies have proved that there is an association between cardiovascular disease (CVD) risk and endocrine and lipid markers at early stages of life. Objective: To establish the relationship between nutritional status (IGF-1 and serum levels of its binding proteins IGFBP-1, IGFBP-2 and IGFBP-3), and CVD risk markers in students aged 7 to 9 years. Materials and methods: Cross-sectional observational study conducted in 84 children attending two schools from Bogotá D.C. and Soacha, Colombia, to identify the relationship between possible variations in CVD risk markers and nutritional status. Sexual development stage, lipid profile, anthropometric data, blood sugar levels and IGF-1 and IGFBP serum levels of all participants were measured. Statistical analysis was conducted using the Pearson's correlation coefficient, the analysis of variance (ANOVA), and the Kruskall-Wallis, Games-Howell and Dunnett's tests. The confidence interval and statistical significance were 95% and p<0.05, respectively. Results: IGFBP-1 and IGFBP-2 levels proportionally decreased as weight increased. An inverse correlation between both proteins and triglyceride levels was found, as well as a direct correlation with HDL cholesterol levels. Conclusions: Alterations in CVD risk markers can be identified during childhood. If said alterations are timely detected, it is possible to adopt preventive and therapeutic actions such as the promotion of public policies aimed at preventing childhood overweight and obesity, which in turn will reduce the risk of developing cardiovascular disease in adulthood.Introducción. Los desequilibrios nutricionales en la infancia afectan la salud tanto en la niñez como en la adultez. Estudios previos demuestran la asociación de marcadores endocrinos y lipídicos con riesgo cardiovascular (RCV) desde edades tempranas. Objetivo. Establecer la relación entre estado nutricional (niveles séricos de IGF-1 y sus proteínas enlazantes IGFBP-1, IGFBP-2 e IGFBP-3) y marcadores de RCV en estudiantes de 7 a 9 años. Materiales y métodos. Estudio observacional comparativo transversal realizado en 84 niños de 2 colegios de Bogotá D.C. y Soacha, Colombia, para identificar la relación entre posibles variaciones de marcadores de RCV y estado nutricional. Se midieron los niveles de glucemia y niveles séricos de IGF-1 e IGFBP, el nivel de desarrollo sexual, el perfil lipídico y los valores antropométricos. Para el análisis estadístico se utilizaron el coeficiente de correlación de Pearson, un análisis de varianza (ANOVA) y las pruebas de Kruskal Wallis, Games-Howell y Dunnett. El intervalo de confianza fue del 95% y la significancia estadística, de p<0.05. Resultados. La reducción en los niveles de IGFB-1 e IGFBP-2 fue directamente proporcional al aumento de peso. Por otra parte, se observó una correlación inversa entre ambas proteínas y concentraciones de triglicéridos, y un...

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Association between insulin-like growth factor-1 and cardiovascular disease risk: Evidence from a meta-analysis

Cited by 13 publications

References 23 publications

Persistent inflammation and endothelial dysfunction in patients with treated acromegaly

Persistent inflammation and endothelial dysfunction in patients with treated acromegaly

Acromegaly, inflammation and cardiovascular disease: a review

Marcadores de riesgo cardiovascular en niños menores de 10 años y su relación con niveles séricos de IGF-1, IGFBP-1, IGFBP-2 e IGFBP-3

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