Association Between Inflammatory Biomarkers in Plasma, Radiological Severity, and Duration of Exposure in Patients With Silicosis

Journal of Occupational &Amp; Environmental Medicine

Avelar³

et al. 2016

Self Cite

Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.

Section: Discussionsupporting

confidence: 89%

Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica

Braz¹,

Journal of Occupational &Amp; Environmental Medicine

Avelar³

et al. 2016

Self Cite

“…5 This led to the ongoing project, "Silicosis Inflammatory Markers". 4,20,33 In this context, the aim of this study was to evaluate serum levels of soluble BMP2, CXCL16, and CCL5, stress oxidative lipid peroxidation (TBARs), superoxide dismutase activity (SOD), nitrite content (NO 2 − ), and nitric oxide in exhaled breath (FeNO) in silica-exposed workers. We hypothesized that these biomarkers could be candidates for distinguishing exposure status, presence of silicosis, and radiological severity of the disease.…”

Section: After the Identification Of Several Silicosis Cases Among Crmentioning

confidence: 99%

“…[11][12][13][14][15] Among those mediators implicated in the pathogenesis of silicosis, the interleukins IL-1β, IL-4, IL-5, IL-6, IL-8, and IL-10 12, [16][17][18] ; tumor necrosis factor (TNF) and its receptor sTNFR1 and sTNFR2; transforming growth factor β (TGF-β), and the chemokines CCL3 and CCL24 have been highlighted. 19,20 Other inflammatory markers such as bone morphogenetic protein (BMP2) and chemokines CCL5 and CXCL16 have been shown to mediate vascular plasticity, angiogenesis, and leukocyte recruitment in distinct tissues 21,22 and, more recently, implicated in potentiating respiratory-inflammatory processes driven by T-cells and macrophages in asthma 23,24 and viral infections. 25 One study demonstrated an association between increased expression of CCR5, which is the receptor for the CCL5 chemokine, in the development of coal workers' pneumoconiosis.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

American J Industrial Med

Algranti

Chérot‐Kornobis

et al. 2020

Background Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. Methods A cross‐sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was performed. Personal respirable dust samples were collected. Plasma inflammatory mediators (bone morphogenetic protein‐ BMP2 and chemokines CXCL16, and CCL5), oxidative stress enzymes (thiobarbituric acid reactive substances [TBARs] and superoxide dismutase [SOD]), and nitrite (NO2−) were analyzed in parallel with nitric oxide in exhaled breath (FeNO). Results Being currently or formerly exposed to silica was related to increased levels of CXCL16 and TBARs. Currently, exposed subjects showed decreased levels of SOD. Thirty‐seven craftsmen with silicosis (26 formerly and 11 currently exposed) showed higher levels of CXCL16, which was positively associated with the radiological severity of silicosis. Compared with the nonexposed, subjects with silicosis had higher levels of TBARs and those with complicated silicosis had lower levels of SOD. In multivariate analysis, higher levels of CXCL16 were associated with exposure status and radiological severity of silicosis. Smoking was not a confounder. FeNO did not distinguish between the exposure status and the presence of silicosis. Conclusion CXCL16 emerged as a potential biomarker that could distinguish both silica exposure and silicosis. TBARs were elevated in exposed individuals. However, their clinical applications demand further investigation in follow‐up studies of representative samples.

“…The service operates within a University Hospital offering diagnostic and management capabilities for pneumoconiosis and its comorbidities. In 2006, the first cases of silicosis from Corinto were seen and the service created a special follow up protocol for craftsmen that led to the creation of the ongoing project “Silicosis Inflammatory Biomarkers,” which assesses clinical and occupational history, the determinants of oxidative stress and blood levels of inflammatory markers [Braz et al, ], exhaled nitric oxide (FeNO) and the mineral content of exhaled breath condensates (EBC), lung function, and chest imaging. Parallel to the clinical protocol, local meetings were organized with workers, firm owners and local authorities to create and improve awareness on the ongoing risks in the work sheds.…”

Section: Introductionmentioning

confidence: 99%

Silica exposure and disease in semi‐precious stone craftsmen, Minas Gerais, Brazil

American J Industrial Med

Braz

Algranti

et al. 2017