Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica

Braz, Nayara Felicidade Tomaz; Carneiro, Ana Paula Scalia; Avelar, Núbia Carelli Pereira de; Miranda, Aline Silva de; Lacerda, Ana Cristina Rodrigues; Teixeira, Mauro Martins; Teixeira, Antônio Lúcio; Mendonça, Vanessa Amaral

doi:10.1097/jom.0000000000000606

Cited by 17 publications

(16 citation statements)

References 25 publications

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“…Combined with TGF- β, IL-6 suppresses Treg generation and induces Th17 differentiation (a cytokine with pathogenic effect in different autoimmune diseases) 21 . Our study, similarly, to Braz et al’s study 22 , shows higher IL-6 serum levels in patients with or without silicosis than in unexposed healthy subjects.…”

Section: Discussionsupporting

confidence: 92%

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Blanco-Pérez

Blanco‐Dorado

Rodrı́guez-Garcı́a

et al. 2021

Sci Rep

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Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of radiological alterations and help monitor the evolution of patients. The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. We conducted a prospective observational study in patients attending the pulmonology clinic from 2009 to 2018. Serum levels of the following inflammatory mediators were assessed: interleukin-6 (IL-6), interleukin 2 receptor subunit alpha (IL2R) interleukin 1 beta (IL1B), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), alpha-1 antitrypsin (AAT), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin in subjects exposed to silica, with and without silicosis. Association between those inflammatory mediators with lung function measurements and radiological severity of disease and their impact on prognosis were analysed. 337 exposed to silica (278 with silicosis) and 30 subjects in the control group were included. IL-8, α1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. IL-8, LDH and AAT levels were associated with progression of silicosis and IL-6, IL-8, LDH, AAT, ferritin, and CRP with vital status. The results of the ROC analysis indicated the potential of IL-8 as a biomarker in the presence of silicosis and for the prediction of mortality.

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Section: Discussionsupporting

confidence: 92%

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Blanco-Pérez

Blanco‐Dorado

Rodrı́guez-Garcı́a

et al. 2021

Sci Rep

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“…Silica causes lysosomal damage in lung phagocytic cells, activating inflammasomes, particularly on the NALP‐3, and triggering an inflammatory cascade of soluble mediators 11,13,48 . Some inflammatory cytokines or their receptors (TNF, TNFR, IL‐6, IFN‐gamma, IL‐8, MARCO‐ macrophage receptor with collagenous structure and FAS‐ligand) have been previously associated with silica‐induced pulmonary tissue damage 33,49,50 The biomarkers, CXCL16, CCL5, and BMP2, although they present biological plausibility in inflammatory processes in the respiratory system, are as yet little explored in groups exposed to silica. In this study, CXCL16 emerged as a potential biomarker to mainly distinguish between the radiological severity among individuals with silicosis and also between silica‐exposed and nonexposed individuals.…”

Section: Discussionmentioning

confidence: 99%

“…5 This led to the ongoing project, "Silicosis Inflammatory Markers". 4,20,33 In this context, the aim of this study was to evaluate serum levels of soluble BMP2, CXCL16, and CCL5, stress oxidative lipid peroxidation (TBARs), superoxide dismutase activity (SOD), nitrite content (NO 2 − ), and nitric oxide in exhaled breath (FeNO) in silica-exposed workers. We hypothesized that these biomarkers could be candidates for distinguishing exposure status, presence of silicosis, and radiological severity of the disease.…”

Section: After the Identification Of Several Silicosis Cases Among Crmentioning

confidence: 99%

“…A previous study estimated that approximately 300 workers were involved in the crystal mining and processing industry in the municipality 5 . This led to the ongoing project, “Silicosis Inflammatory Markers” 4,20,33 . In this context, the aim of this study was to evaluate serum levels of soluble BMP2, CXCL16, and CCL5, stress oxidative lipid peroxidation (TBARs), superoxide dismutase activity (SOD), nitrite content (NO 2 − ), and nitric oxide in exhaled breath (FeNO) in silica‐exposed workers.…”

Section: Introductionmentioning

confidence: 99%

“…MARCO-macrophage receptor with collagenous structure and FASligand) have been previously associated with silica-induced pulmonary tissue damage 33,49,50 The biomarkers, CXCL16, CCL5, and BMP2, although they present biological plausibility in inflammatory processes in the respiratory system, are as yet little explored in groups exposed to silica. In this study, CXCL16 emerged as a potential biomarker to mainly distinguish between the radiological severity among individuals with silicosis and also between silica-exposed and nonexposed individuals.…”

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confidence: 99%

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Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Carneiro

Algranti

Chérot‐Kornobis

et al. 2020

American J Industrial Med

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Background Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. Methods A cross‐sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was performed. Personal respirable dust samples were collected. Plasma inflammatory mediators (bone morphogenetic protein‐ BMP2 and chemokines CXCL16, and CCL5), oxidative stress enzymes (thiobarbituric acid reactive substances [TBARs] and superoxide dismutase [SOD]), and nitrite (NO2−) were analyzed in parallel with nitric oxide in exhaled breath (FeNO). Results Being currently or formerly exposed to silica was related to increased levels of CXCL16 and TBARs. Currently, exposed subjects showed decreased levels of SOD. Thirty‐seven craftsmen with silicosis (26 formerly and 11 currently exposed) showed higher levels of CXCL16, which was positively associated with the radiological severity of silicosis. Compared with the nonexposed, subjects with silicosis had higher levels of TBARs and those with complicated silicosis had lower levels of SOD. In multivariate analysis, higher levels of CXCL16 were associated with exposure status and radiological severity of silicosis. Smoking was not a confounder. FeNO did not distinguish between the exposure status and the presence of silicosis. Conclusion CXCL16 emerged as a potential biomarker that could distinguish both silica exposure and silicosis. TBARs were elevated in exposed individuals. However, their clinical applications demand further investigation in follow‐up studies of representative samples.

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Biomarkers related to silicosis and pulmonary function in individuals exposed to silica

Lombardi,

Mizutani,

Terra‐Filho

et al. 2023

American J Industrial Med

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BackgroundThe identification of markers that can facilitate the early diagnosis of silicosis has remained challenging. We evaluated the association of inflammatory markers with the presence of silicosis and lung function impairment in individuals exposed to silica.MethodsIndividuals exposed and not exposed to silica were assessed by occupational history, clinical findings, lung function, chest imaging findings, and inflammatory markers.ResultsAmong 297 men evaluated, 51 were unexposed controls (G1), 149 were exposed to silica without silicosis (G2), and 97 were exposed to silica with silicosis (G3). Inflammatory marker levels were higher in G3 than in G2 and G1. Platelet/lymphocyte ratio (PLR), lactate dehydrogenase (LDH), soluble tumor necrosis factor II (sTNFRII), and macrophage inflammatory protein‐4 (MIP‐4) were associated with silicosis, and LDH, neutrophil/lymphocyte ratio (NLR), sTNFRII, monocyte chemoattractant protein‐1 (MCP‐1), soluble vascular cell adhesion molecule‐1 (sVCAM‐1), and fibrinogen were negatively associated with lung function.ConclusionBlood inflammatory markers are associated with silicosis and impaired lung function.

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Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica

Cited by 17 publications

References 25 publications

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Biomarkers related to silicosis and pulmonary function in individuals exposed to silica

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