Silica exposure and disease in semi‐precious stone craftsmen, Minas Gerais, Brazil

Carneiro, Ana Paula Scalia; Braz, Nayara Felicidade Tomaz; Algranti, Eduardo; Bezerra, Olivia M.P.A.; Araújo, Natália P S; Hyg, Lênio S. Amaral Eng; Edmé, Jean Louis; Sobaszek, Annie; Chérot‐Kornobis, Nathalie

doi:10.1002/ajim.22682

Cited by 15 publications

(21 citation statements)

References 21 publications

(20 reference statements)

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“…Originally, 118 craftsmen, all male, were seen at the Reference Centre in Occupational Health, in Belo Horizonte, between 2006 and 2014. Details on the work processes, quantitative exposure measurements, and clinical profiles of these workers have been previously reported 4 . During subsequent field visits in 2014 to the city of Corinto, 79 of the 118 patients attended and consented to participate in the present study.…”

Section: Methodsmentioning

confidence: 99%

“…The subjects were evaluated according to our investigation protocol of health effects caused by mineral dust exposure 4 . We collected demographic data and information on clinical and occupational history, including smoking habits, year of first exposure, duration (length) of silica exposure, age at initial exposure, performed tasks, time away from exposure, if applicable, and history of other comorbidities.…”

Section: Methodsmentioning

confidence: 99%

“…Quantitative measurements of personal respirable dust samples were performed between March and May 2014. Fifty‐two samples were collected from six work sheds covering the four main tasks of the craftsmen, as previously reported 4 . The average silica concentration was assumed to be the arithmetic mean of a lognormal distribution for each of the four tasks 45 .…”

Section: Methodsmentioning

confidence: 99%

“…5 This led to the ongoing project, "Silicosis Inflammatory Markers". 4,20,33 In this context, the aim of this study was to evaluate serum levels of soluble BMP2, CXCL16, and CCL5, stress oxidative lipid peroxidation (TBARs), superoxide dismutase activity (SOD), nitrite content (NO 2 − ), and nitric oxide in exhaled breath (FeNO) in silica-exposed workers. We hypothesized that these biomarkers could be candidates for distinguishing exposure status, presence of silicosis, and radiological severity of the disease.…”

Section: After the Identification Of Several Silicosis Cases Among Crmentioning

confidence: 99%

“…3 In Brazil, particularly in the state of Minas Gerais, studies showed a concerning prevalence of silicosis among crystal and precious stone miners and craftsmen, with cases of severe diseases in young individuals. [4][5][6] The classical diagnosis of silicosis requires a combination of consistent exposure history, clinical history, and compatible chest imaging. Patients may be initially asymptomatic or may present an irritative cough and/or shortness of breath upon exertion.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Carneiro

Algranti

Chérot‐Kornobis

et al. 2020

American J Industrial Med

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Background Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. Methods A cross‐sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was performed. Personal respirable dust samples were collected. Plasma inflammatory mediators (bone morphogenetic protein‐ BMP2 and chemokines CXCL16, and CCL5), oxidative stress enzymes (thiobarbituric acid reactive substances [TBARs] and superoxide dismutase [SOD]), and nitrite (NO2−) were analyzed in parallel with nitric oxide in exhaled breath (FeNO). Results Being currently or formerly exposed to silica was related to increased levels of CXCL16 and TBARs. Currently, exposed subjects showed decreased levels of SOD. Thirty‐seven craftsmen with silicosis (26 formerly and 11 currently exposed) showed higher levels of CXCL16, which was positively associated with the radiological severity of silicosis. Compared with the nonexposed, subjects with silicosis had higher levels of TBARs and those with complicated silicosis had lower levels of SOD. In multivariate analysis, higher levels of CXCL16 were associated with exposure status and radiological severity of silicosis. Smoking was not a confounder. FeNO did not distinguish between the exposure status and the presence of silicosis. Conclusion CXCL16 emerged as a potential biomarker that could distinguish both silica exposure and silicosis. TBARs were elevated in exposed individuals. However, their clinical applications demand further investigation in follow‐up studies of representative samples.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: After the Identification Of Several Silicosis Cases Among Crmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Carneiro

Algranti

Chérot‐Kornobis

et al. 2020

American J Industrial Med

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Mortality from silicosis in Brazil: Temporal trends in the period 1980–2017

Algranti

Saito

Carneiro

et al. 2021

American J Industrial Med

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Background: Silicosis is the most prevalent pneumoconiosis in Brazil. We aimed to estimate mortality rates and temporal trends for silicosis, and to identify areas of highest mortality. Methods: Records of silicosis as the underlying (1980-2017) or contributory (2000-2017) cause of death in adults aged 20 years and older were retrieved from the Brazilian Mortality Database. Age-standardized mortality rates (ASMR) were calculated. The annual trend in ASMR was analyzed by joinpoint regression. Mortality rates per 100,000 person-years were calculated for each municipality. We analyzed temporal trends in municipalities where similar activities with exposure to silica were performed. Results: There were 3164 death records (96.6% men) distributed over 14% of the municipalities. Mean age of death was 59.2 (SD 15.1) and mean ASMR was 0.085/100,000 (confidence interval 0.080-0.091). Joinpoint regression showed a significant increase in ASMR from 1980 to 2006 and a significant decrease after 2006 driven by a decline in deaths of individuals younger than 70 years. The highest mortality rate was 21.83/100,000 person-years, in a municipality with small mining operations for gems. Gold mining municipalities showed the highest composite death rate, 4.0/100,000 person-years. Tuberculosis was the main cause of death when silicosis was a contributing cause. Conclusions: In contrast with developed countries, silicosis mortality in Brazil increased to 2006 and subsequently started to drop, mostly from a plateau or decrease in deaths occurring in municipalities which regulated economic activities. However, this decrease did not occur in the older age group nor in the unregulated sector, the latter being the main challenge for exposure control and surveillance.

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Emerging trends in silicosis research: a scientometric review

RenChen,

Wang,

2023

Environ Sci Pollut Res

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Silica exposure and disease in semi‐precious stone craftsmen, Minas Gerais, Brazil

Cited by 15 publications

References 21 publications

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Mortality from silicosis in Brazil: Temporal trends in the period 1980–2017

Emerging trends in silicosis research: a scientometric review

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