Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians

Ghayour‐Mobarhan, Majid; Taylor, Andrew; Lamb, David; Ferns, Gordon A.

doi:10.1038/sj.ijo.0803385

Cited by 20 publications

(15 citation statements)

References 16 publications

(14 reference statements)

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“…Our study is in agreement with previous studies that have shown an association between circulating anti-HSP70 antibody levels and single parameters of the MetS, such as hypertension, obesity, and dyslipidemia (Pockley et al 2002;Ghayour-Mobarhan et al 2007). Ghayour-Mobarhan et al (2007) have investigated the association between obesity indices and HSP antibody titers in 170 healthy participants. Obese patients had significantly higher plasma anti-HSP60, anti-HSP65, and anti-HSP70 concentrations when compared to overweight and normal weight subjects.…”

Section: Discussionsupporting

confidence: 83%

“…It is also a predictive factor for AMI, stroke, and sudden death (Ghayour-Mobarhan et al 2007). Hence, a simple CRP concentration measurement should be performed during an evaluation of cardiovascular risk in postmenopausal women with MetS.…”

Section: Discussionmentioning

confidence: 99%

“…Obese patients had significantly higher plasma anti-HSP60, anti-HSP65, and anti-HSP70 concentrations when compared to overweight and normal weight subjects. The high antibody titers to HSP60, HSP65, and HSP70 in obese subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity (Ghayour-Mobarhan et al 2007). On the other hand, Dulin et al (2010) reported decreases in serum HSP70 and anti-HSP70 levels in patients with established CVD.…”

Section: Discussionmentioning

confidence: 99%

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The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

Nahás

Orsatti

Tardivo

et al. 2014

Cell Stress and Chaperones

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We investigated the association between circulating levels of 60 and 70 kDa heat-shock proteins (HSP60 and 70) and cardiovascular risk factors in postmenopausal women with or without metabolic syndrome (MetS). This crosssectional study included 311 Brazilian women (age ≥45 years with amenorrhea ≥12 months). Women showing three or more of the following diagnostic criteria were diagnosed with MetS: waist circumference (WC) ≥88 cm, blood pressure ≥130/ 85 mmHg, triglycerides ≥150 mg/dl, high-density lipoprotein (HDL) <50 mg/dl, and glucose ≥100 mg/dl. Clinical, anthropometric, and biochemical parameters were collected. HSP60, HSP70, antibodies to HSP60 and HSP70, and C-reactive protein (CRP) levels were measured in serum. Student's t test, Kruskal-Wallis test, chi-square test, and Pearson correlation were used for statistical analysis. Of the 311 women, 30.9 % (96/311) were diagnosed with MetS. These women were, on average, obese with abdominal fat deposition and had lower HDL values as well as higher triglycerides and glucose levels. Homeostasis model assessment-insulin resistant (HOMA-IR) test values in these women were compatible with insulin resistance (P <0.05). CRP and HSP60 concentrations were higher in women with MetS than in women without MetS (P <0.05). HSP60, anti-HSP70, and CRP concentrations increased with the number of features indicative of MetS (P < 0.05). There was a significant positive correlation between anti-HSP70 and WC, blood pressure and HOMA-IR, and between CRP and WC, blood pressure, glucose, HOMA-IR, and triglycerides (P <0.05). In postmenopausal women, serum HSP60 and anti-HSP70 concentrations increased with accumulating features of the metabolic syndrome. These results suggest a greater immune activation that is associated with cardiovascular risk in postmenopausal women with metabolic syndrome.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

Nahás

Orsatti

Tardivo

et al. 2014

Cell Stress and Chaperones

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“…Although smoking (Newkirk et al 2012), hypercholesterolemia (Guisasola et al 2009), and microalbuminuria (Bianchi et al 2008) have been associated with increased circulating anti-Hsp70 levels and cases had greater prevalence/levels of these risk factors, the strength of the association was only slightly reduced by further adjustment for apoB, smoking, and AER. Previous studies have shown an association between circulating anti-Hsp70 antibody levels and single parameters of the MetS, such as hypertension, obesity, and dyslipidemia (Wu et al 2001;Ghayour-Mobarhan et al 2005, 2007; however, these clinically based studies also included patients with type 2 diabetes and established CVD, making detangling analysis open to imprecision. Indeed, anti-Hsp70 antibody levels are often reduced in patients with CVD, likely because of immunocomplex formation (Dulin et al 2010) and diabetic macrovascular/microvascular complications have been associated with lower anti-Hsp70 levels (Gruden et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Circulating anti-Hsp70 levels in nascent metabolic syndrome: the Casale Monferrato Study

Gruden

Barutta

Pinach

et al. 2013

Cell Stress and Chaperones

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The metabolic syndrome (MetS) confers an increased risk of both type 2 diabetes and cardiovascular diseases (CVD). Heat shock protein 70 (Hsp70), an intracellular polypeptide, can be exposed on the plasma membrane and/or released into the circulation, eliciting both native and immune responses that may contribute to vascular damage. Our aim was to assess if serum anti-Hsp70 antibody levels were cross-sectionally associated with uncomplicated MetS. A cross-sectional case-control study from the nondiabetic cohort of the Casale Monferrato Study was performed. Subjects with established CVD and/ or abnormal renal function were excluded. Case subjects (n0180) were defined as those fulfilling the criteria for the diagnosis of MetS. Control subjects (n0136) were completely free of any component of the MetS. Serum antiHsp70 levels were measured by immunoenzymatic assay. We found that anti-Hsp70 antibody levels were significantly higher in cases than in control subjects [122.6 (89.5-155.6) vs 107.1 (77.3-152.4) μg/ml, p00.04], even after age and sex adjustment. In logistic regression analysis, higher levels of log-anti-Hsp70 conferred greater odds ratio (OR) for MetS, independently of age and sex. There was a statistically significant trend of ORs across quartiles of anti-Hsp70 and values greater than 108.0 μg/ml conferred a 77 % increased OR of MetS as compared with values in the lower quartiles. The strength of the association slightly decreased after further adjustment for apolipoprotein B, smoking, and albumin excretion rate. In conclusion, our results show that serum anti-Hsp70 antibody levels are independently associated with nascent MetS.

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“…The rapid increase in the rate of obesity in populations also constitutes a significant, global health problem. Overweight and obesity have unfavorable impact on health, increasing the risk of arterial hypertension, type 2 diabetes, cardiovascular diseases, inflammation of joints and bones and certain types of cancers [HUANG et al 1998, LEITE and NICO-LOSI 2006, GHAYOUR-MOBARHAN et al 2007. The researchers point to a multitude of factors contributing to the occurrence of overweight or obesity related problems, emphasizing the influence of both genetic and environmental factors [MARTI et al 2004, LEITE and NICOLOSI 2006, WANG et al 2006.…”

mentioning

confidence: 99%

Assessment of the BMI, WHR and W/Ht in pre- and postmenopausal women

Skrzypczak

Szwed

Pawlińska-Chmara

et al. 2007

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The main goal of this study was to determine whether and how values of the BMI, WHR and W/Ht indicators change in pre-and postmenopausal women. The tested group consisted of 10,216 women aged 25-95 years. Data were collected during the national campaign "Fighting Obesity", organized by Hand-Prod Company between 2000-2002 across Poland, when adult women voluntarily filled in a questionnaire and participated in anthropometric measurements. The BMI, WHR and W/Ht values were calculated based on these measurements. The values of the BMI, WHR and W/Ht change with age. However, in each age group postmenopausal women have higher BMI, WHR and W/Ht than premenopausal women. Thus, the results obtained indicate that hormonal changes occurring in the climacterium period cause an increase in the analyzed index values. The BMI used herein is characterized by high accuracy in indicating obesity. Moreover, the WHR and W/Ht are also used as adiposity indicators, which may be useful in assessment of the risk of disease or death caused by hypertension, cardiac diseases, diabetes, or even cancers. However, they should not be used only in relation to obese women, because even a slight increase in visceral obesity, with body mass within normal limits, may contribute to unfavorable changes in the woman's metabolic profile, which in turn, may present a risk of illness. KEY WORDS: menopausal status, overweight, obesity, Polish womenThe aging process entails changes in physiological and morphological parameters. The age specific decline in physiological and morphological parameters in women reveals a similar pattern, during which the climacterium plays a large part [HARDY et al. 2000, JUHAERI et al. 2003, PROPER et al. 2007. The

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Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians

Cited by 20 publications

References 16 publications

The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

Circulating anti-Hsp70 levels in nascent metabolic syndrome: the Casale Monferrato Study

Assessment of the BMI, WHR and W/Ht in pre- and postmenopausal women

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