BackgroundSince human diets contain many components that may work synergistically to prevent or promote disease, assessing diet quality may be informative. The purpose of this study was to investigate the association between quality diet, by using Healthy Eating Index (HEI), and metabolic risk indicators in postmenopausal women.MethodsThis cross-sectional study included a total of 173 Brazilian women, aged 45-75 years, seeking healthcare at a public outpatient center. Food consumption assessed by 24 h-recall food inquiry was used to calculate HEI scores: >80 implied diet good, 80-51 diet "needed improvement", and <51 diet poor. Anthropometric data included: body mass index (BMI = weight/height2), waist-circumference (WC), body fat (%BF) and lean mass (%LM). Data on total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and triglycerides (TG) were also collected. Fisher's Exact test, and logistic regression method (to determine odds ratio, OR) were used in the statistical analysis.ResultsOverweight and obesity were observed in 75.7% of the participants. Excessive %BF (> 35%) was observed in 56.1%, while %LM was reduced (< 70%) in 78.1%. WC was elevated (≥88 cm) in 72.3%. Based on HEI values, diet quality was good in 3% (5/173), needed improvement in 48.5% (84/173), and was poor in 48.5% (84/173) of the cases. In this group, 75% of women had high intakes of lipids (> 35%), predominantly saturated and monounsaturated fat. On average, plasma TC, LDLC, and TG levels were higher than recommended in 57.2%, 79.2% and 45.1% of the women, respectively, while HDLC was low in 50.8%. There was association between HEI scores and the %BF that it was higher among women with HEI score < 80 (p = 0.021). There were not observed significant risk associations between HEI and lipid profile.ConclusionAmong the Brazilian postmenopausal women attending a public outpatient clinic, diet was considered to need improvement or to be of poor quality, attributed to high saturated fat ingestion, which probably caused a negative impact on metabolic risk indicators, namely body composition.

In postmenopausal women with metabolic syndrome, dietary intervention plus supplementation of omega-3 resulted in a further decrease in triglycerides and blood pressure and also in an improvement in insulin resistance and inflammatory markers, important components of metabolic syndrome.

In postmenopausal women, age, menopause status, and hyperglycemia are associated with a higher prevalence of ATS, whereas elevated serum HSP70 is associated with a lower prevalence of ATS.

We investigated the association between circulating levels of 60 and 70 kDa heat-shock proteins (HSP60 and 70) and cardiovascular risk factors in postmenopausal women with or without metabolic syndrome (MetS). This crosssectional study included 311 Brazilian women (age ≥45 years with amenorrhea ≥12 months). Women showing three or more of the following diagnostic criteria were diagnosed with MetS: waist circumference (WC) ≥88 cm, blood pressure ≥130/ 85 mmHg, triglycerides ≥150 mg/dl, high-density lipoprotein (HDL) <50 mg/dl, and glucose ≥100 mg/dl. Clinical, anthropometric, and biochemical parameters were collected. HSP60, HSP70, antibodies to HSP60 and HSP70, and C-reactive protein (CRP) levels were measured in serum. Student's t test, Kruskal-Wallis test, chi-square test, and Pearson correlation were used for statistical analysis. Of the 311 women, 30.9 % (96/311) were diagnosed with MetS. These women were, on average, obese with abdominal fat deposition and had lower HDL values as well as higher triglycerides and glucose levels. Homeostasis model assessment-insulin resistant (HOMA-IR) test values in these women were compatible with insulin resistance (P <0.05). CRP and HSP60 concentrations were higher in women with MetS than in women without MetS (P <0.05). HSP60, anti-HSP70, and CRP concentrations increased with the number of features indicative of MetS (P < 0.05). There was a significant positive correlation between anti-HSP70 and WC, blood pressure and HOMA-IR, and between CRP and WC, blood pressure, glucose, HOMA-IR, and triglycerides (P <0.05). In postmenopausal women, serum HSP60 and anti-HSP70 concentrations increased with accumulating features of the metabolic syndrome. These results suggest a greater immune activation that is associated with cardiovascular risk in postmenopausal women with metabolic syndrome.

Objetivo: Caracterizar o atendimento e analisar a adesão de pacientes ao acompanhamento nutricionalna fila de espera para a cirurgia bariátrica em um ambulatório multidisciplinar de atenção secundária àsaúde. Métodos: Foi realizado um estudo retrospectivo a partir de prontuários de nutrição referentes a 59pacientes submetidos à cirurgia bariátrica no Hospital das Clínicas de Botucatu, entre 2001 e 2008. Apopulação estudada foi distribuída e analisada em oito grupos, conforme o tempo de acompanhamento.A análise levou em conta a evolução do peso e o número de retornos no determinado período. Acomparação entre os grupos foi realizada pelo teste de Kruskal-Wallis, enquanto as correlações foramtestadas pelo coeficiente de Spearman. Resultados: Entre os 59 pacientes estudados, 42 retornaram ao serviço ao menos uma vez (71,2%).Destes, 67,8% perderam peso na fila de espera, sendo que 27,1% dos mesmos tiveram redução maiorque 10% no peso corporal. As maiores perdas de peso no pré-operatório foram encontradas nosgrupos que tiveram um acompanhamento nutricional maior que seis meses. Constatou-se uma demoramediana de três meses entre os retornos, o que pode ter contribuído para a baixa adesão ao acompanhamento.Conclusão: Os pacientes da fila de espera para a cirurgia, aqui analisados, apresentaram baixa adesãoao acompanhamento em retornos espaçados. Isso indica que para a desejada redução no pesocorporal e adequado processo educativo aos candidatos à cirurgia bariátrica há que se dispor de tempomínimo de seis meses e encontros regulares.

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A Fibromialgia (FB) é uma doença multifatorial que atinge uma grande parcela da população e ainda tem o seu diagnóstico como motivo de controvérsia. É caracterizada pela dor crônica em múltiplos pontos do corpo. O presente artigo teve como objetivo identificar ativos nutracêuticos que pudessem contribuir ao tratamento da FB nos seus múltiplos aspectos e assim, melhorar a qualidade de vida de seus portadores. O levantamento bibliográfico delimitou-se na busca de artigos em português e inglês nas bases de dados PubMed, SciELO e LILAC, publicados no período de janeiro de 2015 a março de 2020. Os princípios ativos mais encontrados no tratamento da FB foram a coenzima Q10, 25-hidroxivitamina D, probióticos (Lactobacillus Rhamnosus, Casei, Acidophilus e Bifidobacterium Bifidus) e fitoterápicos como gengibre, acerola, Spiraea Ulmari, passiflora, Elymus repens, em associação com outros produtos, o Crocus Sativus (açafrão) além do Ganoderma lucidum que é um tipo de cogumelo. É de fundamental importância a compreensão de como os suplementos podem auxiliar no tratamento da FB promovendo uma terapêutica mais natural, menos dispendiosa e com menos efeitos colaterais para os seus portadores.