Association between IGF-I, IGF-IR and GHRH gene polymorphisms and growth and carcass traits in beef cattle

Curi, Rogério Abdallah; Oliveira, Henrique Nunes de; Silveira, Antônio Carlos; Lopes, Catalina Romero

doi:10.1016/j.livprodsci.2004.10.009

Cited by 66 publications

(59 citation statements)

References 14 publications

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“…In B. taurus cattle, this SNP segregates -for example, in Angus, the frequency of the T allele was 0.64 (Ge et al, 2001) -, whereas in B. indicus, segregation was not observed. The frequency of the C allele in Nelore cattle was previously found to be 1.0 (Curi et al, 2005), which supports the results obtained in the present study. Therefore, these studies reinforce the hypothesis that the T allele could be a mutation only found in B. taurus breeds, since it occurred after the divergence between B. taurus and B. indicus.…”

Section: Resultssupporting

confidence: 93%

“…Previous research on crossbreds (Simmental x Nelore, Angus x Nelore and Canchim, which are all B. taurus x B. indicus crosses) indicated that the C allele of IGF1 is associated with heavier live weight and carcass weight, besides larger REA and BT scores (Curi et al, 2005). In the present work, the observed effect for the allele substitution of the IGF1 SNP on REA (T for C substitution represented an increase of 3.287 cm 2 in REA; p = 0.0078) was no longer significant (p = 0.1173) after applying Bonferroni correction.…”

Section: Resultsmentioning

confidence: 99%

“…Brangus three-way cross cattle showed an intermediate frequency for allele C (Table 1). In studies with more than 20 breeds of cattle, including both dairy and beef cattle of B. taurus and B. indicus, the frequency of the C allele of IGF1 ranged from 0.16 to 1.0 (Ge et al, 2001;Curi et al, 2005;Li et al, 2006;Islam et al, 2009). In B. taurus cattle, this SNP segregates -for example, in Angus, the frequency of the T allele was 0.64 (Ge et al, 2001) -, whereas in B. indicus, segregation was not observed.…”

Section: Resultsmentioning

confidence: 99%

“…Ge et al (1997) identified a single-nucleotide polymorphism (SNP) in the regulatory region of IGF1, located 512 pb upstream of its first codon (AF_017143.1:g.198C>T). This SNP was later associated to growth and carcass composition in Bos taurus and in B. taurus x B. indicus crosses (Ge et al, 2001;Li et al, 2004b;Curi et al, 2005;Islam et al, 2009).…”

Section: Introductionmentioning

confidence: 94%

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Candidate SNPs for carcass and meat traits in Nelore animals and in their crosses with Bos taurus

Curi

Krauskopf

Hadlich

et al. 2012

Pesq. agropec. bras.

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-The objective of this work was to evaluate the effects of single-nucleotide polymorphisms (SNPs) in the genes IGF1 (AF_017143.1:g.198C>T), MSTN (AF_320998.1:g.433C>A), MYOD1 (NC_007313:g.1274A>G) and MYF5 (NC_007303:g.1911A>G) on carcass and meat traits in Nelore (Bos indicus) and Nelore x B. taurus. A total of 300 animals were genotyped and phenotyped for rib eye area (REA), backfat thickness (BT), intramuscular fat (IF), shear force (SF) and myofibrillar fragmentation index (MFI). The effects of allele substitution for each SNP were estimated by regression of the evaluated phenotypes on the number of copies of a particular allele using the general linear model. The polymorphism at IGF1 was non-informative in Nelore animals. In crossbred animals, the IGF1 C allele was associated with greater REA. However, this relation was not significant after Bonferroni correction for multiple testing. The A allele of the MSTN polymorphism was absent in Nelore cattle and was only found in two crossbred animals. The polymorphisms of MYOD1 and MYF5 were little informative in Nelore animals with G allele frequency of 0.097 and A allele frequency of 0.031, respectively. These markers show no association with the analyzed traits in the total sample of evaluated animals.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Candidate SNPs for carcass and meat traits in Nelore animals and in their crosses with Bos taurus

Curi

Krauskopf

Hadlich

et al. 2012

Pesq. agropec. bras.

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show abstract

“…Zhou et al (2005) found in the F2 generation of hybrids Leghorn×broiler Fayoum×broiler, a significant association (at 5% significance level) between IGF1-SNP and average daily gains. Some results of research on the IGF-1 gene polymorphism is associated with growth have been reported in chickens (Sco et al, 2001;Kita et al, 2005;Li et al, 2009), in sheep (Zhang et al, 2008) and in cattle (Curi et al, 2006;Siadkowska et al, 2006;Arman et al, 2012).…”

Section: Body Weight Gainmentioning

confidence: 99%

Association of Insulin-Like Growth Factor-1 Gene Polymorphism at 279 Position of the 5’UTR Region with Body Weight Traits in Broiler Chicken

Al-Hassani¹,

Al-Hassani²,

Abdul-Hass³

2015

Asian J. of Poultry Science

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Insulin-like Growth Factor 1 (IGF-1) gene has been described in several researches as a candidate gene for growth. The present study attempts to identify associations between body weight traits and polymorphism at 279 position of 5'UTR flanking region of IGF-1 gene in broiler chicken. Three hundred broiler chickens from two breeds (Cobb500 and Hubbard F-15) were used in this study. A Single Nucleotide Polymorphism (SNP) at 279 position of 5'UTR region of IGF-1 gene was identified in 20.6 and 60.3% of Cobb500 and Hubbard F-15, respectively, using PCR-RFLP technique. Allele frequencies were 83.87 and 42.80% for T allele and 16.13 and 57.20% for C allele in Cobb500 and Hubbard -15 breeds, respectively. Genotype frequencies were 79.35, 9.03 and 11.61% in Cobb500 and 39.73, 6.16 and 54.11% in Hubbard F-15 for TT, TC and CC genotypes, respectively. As related with mean body weight, different weekly results were noted between Cobb500 and Hubbard F-15 according to genotypes during a period from 3-7 weeks of age. Within all genotypes, the mean body weights were higher (p>0.05) in males than females at 5 and 7 weeks of age. As related with body weight gain, Hubbard F-15 broilers were more affected by IGF-1 genotypes than Cobb500 broilers in the last three weeks of age, also, male broilers were more affected by IGF-1 genotypes than female broilers. The results of this study demonstrated that IGF-1 gene, to some extent, could be a candidate gene that affects growth in broiler chickens.

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Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle

Zhang

2010

Mol Biol Rep

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The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine associations between these polymorphisms and growth traits in Chinese indigenous cattle breeds. Genotyping was performed on 321 animals including 135 Nanyang, 80 Qinchuan, and 106 Jiaxian cattle. No significant differences in growth traits were observed between the genotypes of IGF-IR/TaqI polymorphism in Nanyang cattle. The m-calpain/HhaI, and UCP-3/BglI polymorphisms were associated with body weight, withers height, and body length of 6 months (P < 0.05 or P < 0.01), body length of 18 months (P < 0.05), and body length and heart girth of 24 months (P < 0.01) in Nanyang cattle. In addition, Nanyang cattle aged 12 months with AB genotype of m-calpain/HhaI polymorphism had higher body length and heart girth than those with BB genotype (P < 0.01). The withers height were greater (P < 0.01) in Nanyang cattle aged 12 months with genotype AB of UCP-3/BglI polymorphism than those with genotype BB. The Nanyang cattle aged 24 months with genotype AA had higher withers height than those with genotype BB (P < 0.05). In conclusion, the m-calpain/HhaI and UCP-3/BglI polymorphisms may be used as DNA markers for selection in the breeding process of Nanyang cattle.

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Association between IGF-I, IGF-IR and GHRH gene polymorphisms and growth and carcass traits in beef cattle

Cited by 66 publications

References 14 publications

Candidate SNPs for carcass and meat traits in Nelore animals and in their crosses with Bos taurus

Candidate SNPs for carcass and meat traits in Nelore animals and in their crosses with Bos taurus

Association of Insulin-Like Growth Factor-1 Gene Polymorphism at 279 Position of the 5’UTR Region with Body Weight Traits in Broiler Chicken

Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle

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