Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle

Zhang, Runfeng; Li, Xiaofeng

doi:10.1007/s11033-010-0346-1

Cited by 22 publications

(13 citation statements)

References 15 publications

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“…The most important genes were the zinc finger E-box binding homeobox 2 (ZEB2) (Yamakoshi et al , 2012) on chromosome 2. This gene is involved in pathways regulating early growth and development, fatty acid binding protein 6, (Zheng et al , 2009), skeletal muscle growth rates and with calpain 2 (CAPN2) which is associated with growth in cattle (Zhang and Li, 2011). …”

Section: Resultsmentioning

confidence: 99%

Genome-wide association study for birth, weaning and yearling weight in Colombian Brahman cattle

Martínez¹,

Garavito²,

Gómez³

et al. 2017

Genet. Mol. Biol.

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Genotypic and phenotypic data of 1,562 animals were analyzed to find genomic regions that potentially influence the birth weight (BW), weaning weight at seven months of age (WW) and yearling weight (YW) of Colombian Brahman cattle, with genotyping conducted using Illumina Bead chip array with 74,669 SNPs. A Single Step Genomic BLUP (ssGBLP), approach was used to estimate the proportion of variance explained by each marker. Multiple regions scattered across the genome were found to influence weights at different ages, also dependent on the trait component (direct or maternal). The most interesting regions were connected to previously identified QTLs and genes, such as ADAMTSL3, CAPN2, CAPN2, FABP6, ZEB2 influencing growth and weight traits. The identified regions will contribute to the development and refinement of genomic selection programs for Zebu Brahman cattle in Colombia.

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Section: Resultsmentioning

confidence: 99%

Genome-wide association study for birth, weaning and yearling weight in Colombian Brahman cattle

Martínez¹,

Garavito²,

Gómez³

et al. 2017

Genet. Mol. Biol.

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“…The analysis also indicated that insulin-like growth factor 1 receptor gene IGF1R (ID: 281848) affecting ADG and marbling is involved in seven different pathways. Nonetheless, there was no association between production traits and the genotypes of IGF-IR/TaqI polymorphism [65-67]. This might be because a small number of animals was used to test the association in those analyses.…”

Section: Resultsmentioning

confidence: 99%

Single nucleotide polymorphisms for feed efficiency and performance in crossbred beef cattle

et al. 2014

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BackgroundThis study was conducted to: (1) identify new SNPs for residual feed intake (RFI) and performance traits within candidate genes identified in a genome wide association study (GWAS); (2) estimate the proportion of variation in RFI explained by the detected SNPs; (3) estimate the effects of detected SNPs on carcass traits to avoid undesirable correlated effects on these economically important traits when selecting for feed efficiency; and (4) map the genes to biological mechanisms and pathways. A total number of 339 SNPs corresponding to 180 genes were tested for association with phenotypes using a single locus regression (SLRM) and genotypic model on 726 and 990 crossbred animals for feed efficiency and carcass traits, respectively.ResultsStrong evidence of associations for RFI were located on chromosomes 8, 15, 16, 18, 19, 21, and 28. The strongest association with RFI (P = 0.0017) was found with a newly discovered SNP located on BTA 8 within the ELP3 gene. SNPs rs41820824 and rs41821600 on BTA 16 within the gene HMCN1 were strongly associated with RFI (P = 0.0064 and P = 0.0033, respectively). A SNP located on BTA 18 within the ZNF423 gene provided strong evidence for association with RFI (P = 0.0028). Genomic estimated breeding values (GEBV) from 98 significant SNPs were moderately correlated (0.47) to the estimated breeding values (EBVs) from a mixed animal model. The significant (P < 0.05) SNPs (98) explained 26% of the genetic variance for RFI. In silico functional analysis for the genes suggested 35 and 39 biological processes and pathways, respectively for feed efficiency traits.ConclusionsThis study identified several positional and functional candidate genes involved in important biological mechanisms associated with feed efficiency and performance. Significant SNPs should be validated in other populations to establish their potential utilization in genetic improvement programs.

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“…The IGF1R / Taq I polymorphism within intron 12, detected originally by Moody et al (1996), seems to be exclusive to Bos indicus . To date, very few data are available regarding the effect of this polymorphism on growth and carcass traits in Bos indicus (Curi et al 2005) and Chinese indigenous beef cattle (Zhang and Li 2011). …”

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confidence: 99%

Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor (IGF1R) gene with growth-related traits in Angus cattle

Szewczuk

Zych²,

Wójcik

et al. 2013

J Appl Genetics

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The insulin-like growth factor 1 (IGF-1) is considered to be a factor that mainly regulates growth, differentiation, and the maintenance of various function in numerous tissues through binding to a family of transmembrane tyrosine kinase receptors, signaling primarily through the insulin-like growth factor 1 receptor (IGF-1R) encoded by the IGF1R gene. The objectives of the present study were to estimate the allele and genotype frequencies of the IGF1R/MspI (silent mutation within exon 12) and the IGF1R/TaqI (within the 3′ untranslated region, 3′UTR) gene polymorphisms in beef cattle and to determine associations between these polymorphisms and growth traits. In a preliminary study on 310 Angus calves, association analyses with three production traits (birth weight, BWT; weaning weight adjusted to 210 days, WWT210; and average daily gain, ADG) were conducted. The GG genotype of the IGF1R/e12/MspI polymorphism was significantly associated (P ≤ 0.05) with a higher WWT210 (+5.06 kg) compared to the AG genotype. Polymorphism within the 3′UTR had no significant effect on growth traits. The effect of combined genotypes was also examined. At WWT210, calves with the GG/AA and GG/AG combinations were heavier than calves with the AG/AA and AG/AG combined genotypes (P ≤ 0.05). To our knowledge, this is the first report of a polymorphism within the coding region of the Bos taurus IGF1R gene.

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Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle

Cited by 22 publications

References 15 publications

Genome-wide association study for birth, weaning and yearling weight in Colombian Brahman cattle

Genome-wide association study for birth, weaning and yearling weight in Colombian Brahman cattle

Single nucleotide polymorphisms for feed efficiency and performance in crossbred beef cattle

Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor (IGF1R) gene with growth-related traits in Angus cattle

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