Association between IGF-1 polymorphisms and risk of osteoporosis in Chinese population: a meta-analysis

Abstract

BackgroundSeveral studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcomes. The present systematic review and meta-analysis was performed to appraise and synthesize the existing evidence, so as to provide a more precise and reliable association between polymorphisms in IGF-1 gene and osteoporosis.MethodsFive electronic databases including PubMed, EMBASE, ISI Web of Science, CNKI and Wanfang were systematically searched for potential studies. Summary odds ratio (OR) and corresponding 95% confidence interval (95% CI) were calculated to evaluate the association. The best-matching genetic model of inheritance was determined using a genetic-model free approach.ResultsSix case-control studies comprising 2068 osteoporosis patients and 2071 healthy controls were obtained for the meta-analysis. Dominant model was confirmed to be the best-matching genetic model (TT + TC versus CC). The overall data suggested that rs35767 polymorphism was significantly associated with osteoporosis vulnerability (OR 1.21, 95% CI 1.07, 1.37; P = 0.002). When stratifying the participants and performing subgroup-analysis according to source of patients, the result suggested that rs35767 was significantly correlated to osteoporosis in post-menopausal women subgroup (OR 1.29, 95% CI 1.08, 1.54; P = 0.005), but the correlation was not established in the subgroup of both gender (OR 1.14, 95% CI 0.96, 1.35; P = 0.12).ConclusionTaken together, the findings of our current study suggested a significant association between rs35767 polymorphism and risk of osteoporosis in Chinese post-menopausal women.Electronic supplementary materialThe online version of this article (10.1186/s12891-018-2066-y) contains supplementary material, which is available to authorized users.

p53 plays a central role in the development of osteoporosis

“…CDK1, which is essential for osteoblast proliferation, functions as a molecular switch that shifts osteoblast proliferation to maturation [ 22 ]. IGF-1 is a key regulator of longitudinal skeletal growth and is an anabolic hormone that influences bone modeling and remodeling throughout life [ 19 ]. Finally, sustained activation of ErbB1 and ErbB2 enhances hMSC osteogenesis [ 24 ].…”

Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases

“…Moreover, the gla matrix protein (MGP) plays an important role in bone and vascular mineralization, as confirmed by a MGP-deficient murine model, where -138T > C, -7G > A, and Thr83Ala SNPs were associated with bone loss [168]. Similarly, rs2288377, rs35767, and rs2229765 polymorphisms within Insulin-like growth factor (IGF) genes, which are critical regulators for bone cell function [169][170][171], and T116G and G287T polymorphisms in exon 2, and A224T in exon 3 of BMP-2 gene, have been strongly associated with osteoporosis [172].…”

Is diabetes mellitus a risk factor for low bone density: a systematic review and meta-analysis

“…Clinically, low bone density most often occurs through estrogen reduction in postmenopausal women and age-related bone loss in females [ 5 , 6 ]. Other risk factors of osteoporosis included gene, cigarette smoking, alcohol consumption, abnormally high plasma serum parathyroid hormone (PTH) levels, physical inactivity, and chronic use of some medications, for example, corticosteroids [ 7 – 9 ]. Inadequate physical activity always leads to a sedentary lifestyle in the elderly, paralyzed, or limited activity due to accelerated bone loss [ 10 – 12 ].…”