Atomically
dispersed catalysts with maximum efficiencies for atom
utilization have emerged as a frontier in the catalytic field. However,
single-component monatomic catalysts are rarely reported for the overall
photocatalytic water splitting reaction (OWS). Herein, a two-component
synergistic photocatalyst was designed that contained a dispersion
of single-atom Co (CoSAs) centers and PtCo alloy nanoparticles
(Nps), which were supported over C3N4 nanosheets.
Among these components, CoSAs centers act as highly active
sites for the hydrogen evolution reaction (HER), and PtCo alloys act
as highly active sites for the oxygen evolution reaction (OER). A
synergistic effect between them occurs when the two different reactive
centers are combined, indicating that there may be a spillover phenomenon
of protons or hydroxyl groups between the CoSAs centers
and PtCo alloy NPs. The synergistic promotion of CoSAs centers
and PtCo alloys bridges the gap between achieving maximum atom utilization
and optimal bifunctional activities for OWS reactions. This combination
provides a promising model for the development of OWS by atomically
dispersed catalysts.
Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms underlying the antiosteoporotic effects of resveratrol remain largely unknown. In the present study, KEGG pathway enrichment analysis of resveratrol-targeted genes identified 33 associated pathways, 12 of which were also involved in osteoporosis. In particular, the MDM2/p53 signaling pathway was identified as a potential key pathway among the shared pathways. In vitro experiments indicated that MDM2-mediated p53 degradation induced osteoblast differentiation, and resveratrol could partially reverse p53-dependent inhibition of osteogenic differentiation. These findings suggest resveratrol may alleviate osteoporosis at least in part by modulating the MDM2/p53 signaling pathway.
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