Association between human herpes virus and aggressive periodontitis: A systematic review

Alzahrani, Ahmed

doi:10.1016/j.sjdr.2016.06.004

Cited by 13 publications

(14 citation statements)

References 31 publications

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“…Our finding of EBV in 11% of patients clinically diagnosed with aggressive periodontitis compared favorably to those from other studies, in which ranges from 7.5% to 72.2% were reported. Our finding of 0% for both HSV‐2 and HCMV was also supported …”

Section: Discussionsupporting

confidence: 82%

“…Based on the hypothesis that the presence of herpes viruses would be significantly higher among patients with periodontitis, our study showed that its presence was high in aggressive periodontitis (55%), although this was not statistically significant (Fisher's exact test, P = 0.147). This seems to have been the conclusion for several other studies, which found that herpes viruses target host cells by attaching onto the cell surface through glycoproteins present in the viral envelope, stimulating local cytokine production through macrophages and other inflammatory cells. This phenomenon coincides with the state of elevated localized inflammatory burden due to increased gingival crevicular fluid cytokine levels in aggressive periodontitis, which leads to the impairment of local periodontal immune defense .…”

Section: Discussionsupporting

confidence: 54%

“…This seems to have been the conclusion for several other studies, which found that herpes viruses target host cells by attaching onto the cell surface through glycoproteins present in the viral envelope, stimulating local cytokine production through macrophages and other inflammatory cells. This phenomenon coincides with the state of elevated localized inflammatory burden due to increased gingival crevicular fluid cytokine levels in aggressive periodontitis, which leads to the impairment of local periodontal immune defense . This association has also been suggested to be modified by several environmental factors, such as comorbidities, oral hygiene, stress, smoking, and alcohol .…”

Section: Discussionsupporting

confidence: 54%

“…Herpes viruses are known to be the most common group of viruses found in humans, infecting 80%‐90% of the global adult population, consisting of an eight‐membered family known to cause human disease: Epstein‐Barr virus (EBV); human cytomegalovirus (HCMV); herpes simplex virus (HSV) 1 and 2; varicella zoster virus; and human herpes virus 6, 7, and 8 . While periodontal disease itself has varying forms of clinical manifestations, ranging from gingivitis to chronic and aggressive periodontitis, HCMV, EBV and HSV have been detected in the subgingival samples of some patients . The latent form of HCMV has also been seen in many chronic periodontitis sites, which some have suggested could account for the slow progression of the disease .…”

Section: Introductionmentioning

confidence: 99%

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Detection of herpes viruses in Ghanaian patients with periodontitis

Blankson

Obeng‐Nkrumah

et al. 2019

J of Invest & Clin Dent

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Aim The complexity of periodontitis in both etiology and progression has raised many questions, necessitating enormous research in recent years. The aim of the present study was to detect the presence of herpes viruses in Ghanaian patients diagnosed with periodontitis. Methods Thirty‐one patients were included in the study; 21 with periodontitis classified into localized chronic, generalized, and aggressive periodontitis, and 10 without the disease were used as controls. Subgingival samples were collected, followed by DNA extraction. Multiplex polymerase chain reaction was used to amplify viral DNA for the detection of herpes viruses. Data was analyzed using Stata 14. Results The mean age for patients with aggressive periodontitis was 32.2 years (standard deviation [SD]: 8.50), while those for localized chronic periodontitis and generalized chronic periodontitis were 40.6 years (SD: 7.83) and 46.3 years (SD: 12.12), respectively. Viruses were detected only among patients clinically diagnosed with aggressive periodontitis. Of the total number of aggressive periodontitis patients, herpes simplex virus 1 (HSV‐1) and Epstein‐Barr virus (HBV) were found in four (44%) and one (11%), respectively. The mean age for patients found to have HSV‐1 or EBV was 29 years (SD: 6.93). Conclusion We found HSV‐1 and EBV in the subgingival plaque samples of Ghanaian patients clinically diagnosed with aggressive periodontitis. While our finding requires further investigation, the role of HSV in periodontitis, if elucidated, could transform and inform the clinical management of the condition.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 54%

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Detection of herpes viruses in Ghanaian patients with periodontitis

Blankson

Obeng‐Nkrumah

et al. 2019

J of Invest & Clin Dent

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“…Table shows the summarized prevalence of periodontal herpesviruses from 50 worldwide studies. Recent publications have corroborated a high prevalence of herpesviruses in periodontitis and peri‐implantitis …”

Section: Herpesviruses In Periodontal Diseasementioning

confidence: 84%

Periodontal herpesvirus morbidity and treatment

Slots

2019

Periodontology 2000

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Four billion individuals worldwide have a history of periodontitis, with the poorest people in society most affected. Periodontitis can lead to unsightly drifting of teeth and tooth loss that may interfere with the wellbeing of daily living and has also been linked to at least 57 medical diseases and disabilities. The etiology of severe periodontitis includes active herpesviruses, specific bacterial pathogens, and destructive immune responses, but herpesviruses seem to be the major pathogenic determinant. Periodontal herpesviruses that disseminate via the systemic circulation to nonoral sites may represent a major link between periodontitis and systemic diseases. Current treatment of periodontitis focuses almost exclusively on bacterial biofilm and will require revision. Periodontal therapy that targets both herpesviruses and bacterial pathogens can provide long‐term clinical improvement and potentially reduces the risk of systemic diseases. Molecular diagnostic tests for periodontal pathogens may enable early microbial identification and preemptive therapy. This review details an efficient and reliable anti‐infective treatment of severe periodontitis that can be carried out in minimal time with minimal cost.

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