Herpesviruses in Periodontitis: An Umbrella Review

Herpes simplex virus type 1 in periapical pathoses: Systematic review and meta‐analysis

“…Moreover, herpesvirus infection has been hypothesized to contribute to an increased bone resorption due to the differentiation of precursor cells into osteoclasts (Jakovljevic et al, 2020; Jakovljevic & Milasin, 2021). However, except the presence of herpesviral DNA and/or RNA in investigated apical periodontitis samples, there is no evidence of a direct virus involvement in this dental pathology (Jakovljevic et al, 2022). Thus, the knowledge of the possible interaction between herpesviruses and periapical symptomatic or asymptomatic infections could be beneficial for rapid diagnosis and treatment of these frequent pathological events.…”

“…Second, with just two exceptions and accounting also for the excluded studies, all articles were published between 2003 and 2011, and only one article was published in 2020 (Table 1, Table S1). Nevertheless, the publication of many recent qualitative and semiquantitative reviews (Bronzato et al, 2021; Hernández Vigueras et al, 2016; Jakovljevic et al, 2022; Jakovljevic & Milasin, 2021; Siqueira Jr & Rôças, 2022) suggests that the interest in periapical HSV‐1 infection is not over. Therefore, although publication bias was investigated with methods that were proper for prevalence studies and an adjustment was proposed (Table 2), it is not possible to exclude that there were other primary studies, probably from gray literature and recently published, that were not detected.…”