Association between Helicobacter pylori concentration and the combining frequency of histopathological findings in gastric biopsies specimens

Abstract

-Background -Helicobacter pylori is the most prevalent infectious agent worldwide. About 90% of patients with chronic gastritis are infected with this bacterium. Some studies have shown a association between the H. pylori concentration and the scores of gastritis activity and severity. Aim -To evaluate the association between H. pylori concentration and the combining frequency of findings on histopathological examination. Methods -Two hundred consecutive gastric endoscopic biopsies diagnosed as chronic gastritis were retrospectively investigated. The Warthin-Starry silver stain was used to study H. pylori and the following parameters were assessed (according to the Sydney system): 1. infiltration by polymorphonuclear cells in chorio and epithelium (activity) graded as mild, moderate and marked; 2. presence of lymphoid follicles; 3. presence of intestinal metaplasia; 4. presence of regenerative cell atypias, graded as mild, moderate and marked; and 5. H. pylori concentration on the mucous covering the foveolar epithelium. Results -The most frequent association was chronic gastritis and activity, regardless of H. pylori concentration. The association of five histopathological findings in the same biopsy has not occurred in the cases of higher concentration of H. pylori. Conclusion -Our study has not revealed any association between H. pylori concentration and an increasing in the number of histopathological findings found in the gastric mucosa. Since referring to its presence is much more important than to its concentration. HEADINGS -Gastritis. Helicobacter pylori. Helicobacter infections. Biopsy.

Scintigraphic evaluation of gallbladder motor functions in H pylori positive and negative patients in the stomach with dyspepsia

“…It has been reported that impairment of gallbladder dynamic functions might be due to inflammation resulting from H pylori infection. In our dyspeptic patients, high incidence of H pylori infection (67%) and delayed GBFT support the hypothesis that this bacteria can cause dyspepsia [2,7,15,16] . On the other hand, since H pylori was found as negative in 33% of our dyspepsia patients, it seemed unlikely that H pylori was the unique factor for dyspepsia.…”

“…The H pylori colonizing on the surface of the upper gastrointestinal mucosa is an interesting cause of active chronic gastritis and duodenitis or even gastric cancer worldwide [2][3][4][5][6][7] . The presence of H pylori infection could predispose to various disorders [8][9][10][11][12][13][14] .…”

“…The H pylori infection is one of the most common chronic infections in humans [1,2] . The H pylori colonizing on the surface of the upper gastrointestinal mucosa is an interesting cause of active chronic gastritis and duodenitis or even gastric cancer worldwide [2][3][4][5][6][7] .…”

Immunohistopathological Role of Bcl2 and P53 Gene Expression in Helicobacter Pylori Cytotoxin-Associated Gene a Positive Versus Cytotoxin-Associated Gene a Negative Antral Predominant Non-Atrophic Gastritis in Iraqi Patients

“…Significant correlations were detected between HP CagA, inflammation activity grades, and inflammation intensity grades that come in line with others stated that significant correlation was found between HP density and the grade of acute and chronic inflammation [36,37].…”

“…A significant difference in inflammation activity grades as well as in inflammation intensity grades between CagA positive versus CagA negative APNG patients which come in accordance with others [37,54]. Chronic inflammation due to persistent HP infection expected to cause repetitive degeneration and regeneration of the mucosal epithelium that could facilitate malignant transformation.…”