Association between green tea intake and risk of gastric cancer: a systematic review and dose–response meta-analysis of observational studies

Huang, Yan-Hong; Chen, Hongru; Zhou, Liang; Li, Gaoming; Yi, Dali; Zhang, Yanqi; Wu, Yazhou; Liu, Xiaoyu; Wu, Xiaojiao; Song, Qifan; Liu, Ling; Yi, Dong

doi:10.1017/s1368980017002208

Cited by 43 publications

(27 citation statements)

References 47 publications

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“…One of the most prominent associations identified in the current umbrella review was that between tea consumption and diverse cancers; beneficial associations of tea consumption with gastric cancer, oral cancer, lung cancer, biliary tract cancer, thyroid cancer, ovarian cancer, leukemia, and glioma, and of green tea consumption with esophageal cancer and endometrial cancer we observed, although most of these had substantial heterogeneity that might not be readily explained by the epidemiological design, sex, or other important determinants for decreasing the risk of developing cancer. Interestingly, in most cohort and case‐control studies, cancer risk reduction was more frequently observed with green tea consumption.…”

Section: Discussionmentioning

confidence: 83%

“…According to dose–response analyses, the intake of six cups of green tea per day was associated with a 21% (0.79, 0.63–0.97) decreased risk of gastric cancer and a 41% (0.59, 0.42–0.82) decreased risk over 25 years. An increase in green tea consumption of one cup per day was associated with an 11% decreased risk of endometrial cancer (0.89, 0.84–0.94) and a 4% decreased risk of liver cancer (0.96, 0.92–0.99) .…”

Section: Resultsmentioning

confidence: 91%

“…Five grades of green tea consumption were assigned for dose–response of gastric cancer. The risk of gastric cancer showed an increasing trend with increasing tea temperature ( p = 0.02 for non‐linearity), and drinking very hot tea (55–67 ℃) was significantly associated with a high risk of gastric cancer (7.60, 1.67–34.60) …”

Section: Resultsmentioning

confidence: 91%

“…Of the 35 included meta‐analyses that reported a p‐ value for publication bias, three reported statistical evidence for publication bias. These included leukemia ( p = 0.03), lung cancer ( p = 0.005) and gastric cancer ( p = 0.025) . Meta‐analyses on esophageal cancer and PD reported borderline significant publication bias ( p = 0.05).…”

Section: Resultsmentioning

confidence: 95%

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Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Zhuang

et al. 2019

Molecular Nutrition Food Res

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Scope The aim of this article is to conduct an umbrella review to study the strength and validity of associations between tea consumption and diverse health outcomes. Methods and results Meta‐analyses of observational studies examining associations between tea consumption and health outcomes in all human populations and settings are screened. The umbrella review identifies 96 meta‐analyses with 40 unique health outcomes. Tea consumption shows greater benefits than harm to health in this review. Dose–response analyses of tea consumption indicates reduced risks of total mortality, cardiac death, coronary artery disease, stroke, and type 2 diabetes mellitus with increment of two to three cups per day. Beneficial associations are also found for several cancers, skeletal, cognitive, and maternal outcomes. Harmful associations are found for esophageal and gastric cancer when the temperature of intake is more than 55–60 °C. Conclusion Tea consumption, except for very hot tea, seems generally safe at usual levels of intake, with summary estimates indicating the largest reduction for diverse health outcomes at two to three cups per day. Generally, tea consumption seems more beneficial than harmful in this umbrella review. Randomized controlled trials are further needed to understand whether the observed associations are causal.

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Section: Discussionmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 95%

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Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Zhuang

et al. 2019

Molecular Nutrition Food Res

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“…This is often referred to as a "Mediterranean diet". There are contradictory results on the effects of garlic consumption, whereas data is overall in favour of a protective effect by long-term consumption of green tea [86].…”

Section: Primary Preventionmentioning

confidence: 99%

The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract

Bornschein

Bird‐Lieberman

Malfertheiner

2019

Dig Dis

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While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett’s oesophagus (BO) is gastro-oesophageal reflux, the infection with Helicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention. Early detection of neoplastic lesions in Barrett’s metaplasia can be achieved by surveillance endoscopies. Novel endoscopic imaging modalities carry similar importance as the endoscopic treatment techniques as without detection of early lesions, therapy cannot be applied. Minimally invasive approaches are currently being investigated to identify patients with BO who are at particular risk of neoplastic progression. While dietary factors also play an important role in the prevention of gastric cancer and chemoprevention seems to be promising, the most beneficial effect has been shown for the eradication of H. pylori infection, which results in at least a one third reduction of gastric cancer risk. This effect can be further improved if the eradication takes place prior to the development of pre-neoplastic gastric conditions such as mucosal atrophy or intestinal metaplasia (IM). The definition of the “point of no return”, after which eradication is less effective, is of high importance, although H. pylori eradication can still be beneficial even at more advance stages of mucosal changes. For this reason, patients with advanced atrophy and IM should undergo endoscopic surveillance in the same way as patients with BO. There is also need for development of non-invasive tests to identify patients at high risk of progression to gastric cancer to improve outcome of these surveillance approaches.

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Green tea (Camellia sinensis) for the prevention of cancer

Filippini

Malavolti

Borrelli

et al. 2020

Cochrane Database of Systematic Reviews

137

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Association between green tea intake and risk of gastric cancer: a systematic review and dose–response meta-analysis of observational studies

Cited by 43 publications

References 47 publications

Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract

Green tea (Camellia sinensis) for the prevention of cancer

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