Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Yi, Mengshi; Wu, Xiaoting; Zhuang, Wen; Xia, Lin; Chen, Yi; Zhao, Rui; Wan, Qianyi; Li, Du; Zhou, Yong

doi:10.1002/mnfr.201900389

Cited by 78 publications

(68 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results suggested that EGCG, a natural tea polyphenol may play a potential role in suppressing PCSK9. Over the past decades, the traditional conception that green tea consumption offers a sense of beneficial effects for human health, particularly in the areas of cardiovascular diseases [38,39]. Nicolas Danchin, a key note speaker reported that drinking tea can lower the risk of non-cardiovascular mortality by 24% at 2014 ESC Congress.…”

Section: Discussionmentioning

confidence: 99%

Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a

et al. 2020

View full text Add to dashboard Cite

Background: Green tea drinking has been proven to lower lipid and exert cardiovascular protection, while the potential mechanism has not been fully determined. This study was to investigate whether the beneficial impact of epigallocatechingallate (EGCG), a type of catechin in green tea on lipids is associated with proprotein convertase subtilisin/kexin type 9 (PCSK9) pathways. Methods: We studied the effects and underlying molecular mechanism of EGCG or green tea on regulating cholesterol from human, animal and in vitro. Results: In the age-and gender-matched case control observation, we found that individuals with frequent tea consumption (n = 224) had the lower plasma PCSK9 and low density lipoprotein cholesterol (LDL-C) levels compared with ones without tea consumption (n = 224, p < 0.05). In the high fat diet (HFD) fed rats, EGCG administration significantly lowered circulating PCSK9 concentration and liver PCSK9 expression, along with up-regulated LDL receptor (LDLR) expression but decreased level of LDL-C. In hepatic cell study, similar results were obtained regarding the impact of EGCG on LDLR and PCSK9 expression. The assay transposase-accessible chromatic with high-throughput sequencing (ATAC-seq) and subsequent results suggested that two transcription factors, hepatocyte nuclear factor-1α (HNF-1α) and forkhead box class O (FoxO) 3a involved in inhibitory action of EGCG on PCSK9 expression. Conclusions: The present study demonstrates that EGCG suppresses PCSK9 production by promoting nuclear FoxO3a, and reducing nuclear HNF1α, resulting in up-regulated LDLR expression and LDL uptake in hepatocytes. Thereby inhibiting liver and circulating PCSK9 levels, and ultimately lowering LDL-C levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a

et al. 2020

View full text Add to dashboard Cite

show abstract

“…That might cause the different results. Studies have shown that drinking tea could lower all-cause mortality, risks of stroke and diabetes, and improve blood pressure, total cholesterol and LDL (62,63) . Those studies were on tea without sugar.…”

Section: Discussionmentioning

confidence: 99%

High sugar-sweetened beverage intake frequency is associated with smoking, irregular meal intake and higher serum uric acid in Taiwanese adolescents

Shih

Chang

et al. 2020

J Nutr Sci

View full text Add to dashboard Cite

Types of sugar-sweetened beverages (SSB) can differ greatly between countries, with greater consumption of sweetened tea in Asia. This study aimed to understand changes in SSB consumption by adolescents in Taiwan over 18 years and their association with demographic characteristics and clinical outcome. This study used survey data from the 1993–1996 and 2010–2011 Nutrition and Health Surveys in Taiwan. Participants were high school students aged 13 to 18 years. Data were weighted and analysed using SUDAAN 11.0 and SAS 9.4. Participants were asked about intake frequencies of SSB and were grouped into four different SSB intake groups based on the combination of high or low frequency (including moderate frequency) of intake of sweetened tea and soda/sports/energy drinks. Results indicated over 99 % of teens reported having at least one SSB in the past week. Smoking status was significantly associated with SSB intake types with high tea intake (high tea and low soda (HL) group, OR 7·56, P < 0·001; high tea and high soda (HH) group, OR 9·96, P < 0·001). After adjustment for potential confounders, adolescents in the low tea and high soda (LH) group (β = 0·05, P = 0·034) had significantly higher mean serum uric acid values. In conclusion, sugary tea remains the SSB of choice for Taiwanese adolescents. Those with a frequent intake of soda/sports/energy drinks had a higher chance of being hyperuricaemic.

show abstract

“…Tea, produced from the buds and young leaves of Camellia sinensis , has been a beverage consumed and appreciated worldwide for hundreds years. Over the past several decades, the popularity of tea has further increased as amounting studies have shown its health‐promoting effects against cancer, obesity, diabetes, cardiovascular, and other diseases (Rameshrad et al , Yi et al ). These health effects are often associated with the rich flavonoid content in tea, especially catechins (flavan‐3‐ols), which account for 10–23% of the dry weight of tea (Jin et al ).…”

Section: Introductionmentioning

confidence: 99%

Inheritance and quantitative trait loci analyses of the anthocyanins and catechins of Camellia sinensis cultivar ‘Ziyan’ with dark‐purple leaves

Tan

Yang

Zhou

et al. 2020

Physiologia Plantarum

View full text Add to dashboard Cite

Owing to the potential health benefits, anthocyanin-rich teas (Camellia sinensis) have attracted interest over the past decade. Previously, we developed the cultivar 'Ziyan,' which has dark-purple leaves because of the accumulation of a high amount of anthocyanins. In this study, we performed a genetic analysis of this anthocyanin-rich tea cultivar and 176 of its naturally pollinated offspring. For two consecutive years, we quantified the anthocyanins and catechins of 'Ziyan' and the offspring population. While >60% of the offspring accumulated less than half of the amount of anthocyanins of 'Ziyan,' 17 (2018) and 15 (2019) individuals exceeded 'Ziyan' in anthocyanin content. A negative correlation between anthocyanin and total catechin content (r = −0.59, P < 0.001) was observed. The population was genotyped with 131 SSR markers spanning all linkage groups of the C. sinensis genome. Kruskal-Wallis tests identified 10 markers significantly associated with anthocyanins, catechins and their ratios in both years. Quantitative trait locus (QTL) analyses using the interval mapping method detected 13 QTLs, suggesting the dark-purple trait of 'Ziyan' is because of the pyramiding of anthocyanin-promoting alleles on at least five linkage groups. Two genetic loci reversely related to anthocyanin and total catechin contents were identified. This study provides valuable information for genetic improvement of purple tea cultivars and for finemapping related genes. effects against cancer, obesity, diabetes, cardiovascular, and other diseases (Rameshrad et al. 2017, Yi et al. 2019). These health effects are often associated with the rich flavonoid content in tea, especially catechins (flavan-3-ols), which account for 10-23% of the dry weight of tea (Jin et al. 2014).

show abstract

Tea Consumption and Health Outcomes: Umbrella Review of Meta‐Analyses of Observational Studies in Humans

Cited by 78 publications

References 94 publications

Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a

Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a

High sugar-sweetened beverage intake frequency is associated with smoking, irregular meal intake and higher serum uric acid in Taiwanese adolescents

Inheritance and quantitative trait loci analyses of the anthocyanins and catechins of Camellia sinensis cultivar ‘Ziyan’ with dark‐purple leaves

Contact Info

Product

Resources

About