Association between genetic polymorphism of heme oxygenase 1 promoter and neonatal hyperbilirubinemia: a meta-analysis

Zhou, Jinfu; Luo, Jinying; Zhu, Wenbin; Yang, Changyi; Zeng, Yanli; Qiu, Xiaolong

doi:10.1080/14767058.2019.1570115

Cited by 10 publications

(13 citation statements)

References 37 publications

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“…The assessment of this genetic variation may be useful to consider phenobarbital treatment depending on their respective ethnic group populations. Considering the varied genetic makeup of Indonesia and Southeast Asian populations, even compared to Indian and East Asian populations, further studies in not only UGT1A1, but other genes, e.g., HMOX1, BLVRA, and SLCO1B1, especially those closely-related with hyperbilirubinemia or drug delivery are warranted (46–48). Approach and treatment of infants with hyperbilirubinemia and other UGT1A1- related drug therapies should be based on the considerations of SNPs specific for Southeast Asian populations.…”

Section: Discussionmentioning

confidence: 99%

Profiling of UGT1A16, UGT1A160, UGT1A193, and UGT1A128 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing

et al. 2019

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Background: Single nucleotide polymorphism (SNP) variants of the uridine diphosphate glucuronosyltransferase 1A1 ( UGT1A1 ) gene have been studied as an important factor in neonatal hyperbilirubinemia (jaundice) severity. Specific ethnicities, including Asians, have certain SNPs that appear more frequently than others. Aim: To identify the most common SNPs in Indonesian neonates and their association with the severity of neonatal hyperbilirubinemia. Methods: Eighty-eight inborn and outborn jaundiced infants from three different hospitals (Bengkulu, Jakarta, Biak Papua) across Indonesia were enrolled in this cross-sectional study and their peak total serum bilirubin (TSB) levels assessed. SNP variant analyses of the TATAA box, promoter, and exon 1 regions of UGT1A1 gene from 78 of the 88 infants were carried out using the SNaPshot R Multiplex Polymerase Chain Reaction (PCR) System followed by DNA sequencing. Results: We detected SNP variants UGT1A1 * 28, UGT1A1 * 60, UGT1A1 * 93 , and UGT1A1 * 6 in our population. Mean total serum bilirubin (TSB) was 14.59 ± 5.57 mg/dL. Bivariate analyses using delivery location, gestational age, birth weight, mother's age, and ethnicity were shown to be associated with moderate-to-severe hyperbilirubinemia ( p < 0.05). None of the four SNPs appeared to be associated with moderate-to-severe hyperbilirubinemia. In multivariate analysis, however, only the “other ethnic group” (e.g., Chinese, Bengkulu, Papua, Bima) category showed an association with moderate-to-severe hyperbilirubinemia, with an odds ratio of 6.49 (95% CI 1.01–41.67; p < 0.05). Conclusions: We found that the UGT1A1 * 60 is the most common SNP detected in neonates with hyperbilirubinemia in the Indonesian population. Interestingly, in Indonesia, UGT1A1 polymorphisms do not appear to be associated with differences in the severity of hyperbilirubinemia.

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Section: Discussionmentioning

confidence: 99%

Profiling of UGT1A16, UGT1A160, UGT1A193, and UGT1A128 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing

et al. 2019

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“…They also stated that the standardization of the definition of short (GT) n repeats is required [ 59 ]. In addition, Zhou et al, in their meta-analysis, reported that newborns with short (GT) n may be at an increased risk of neonatal hyperbilirubinemia; however, it is important to note that most of the studies included were from the Asian population [ 60 ].…”

Section: Neonatal Jaundicementioning

confidence: 99%

The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease

Nakasone

Ashina

Abe

et al. 2021

IJERPH

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Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway, which degrades heme into equimolar amounts of carbon monoxide, free iron, and biliverdin. Its inducible isoform, HO-1, has multiple protective functions, including immune modulation and pregnancy maintenance, showing dynamic alteration during perinatal periods. As its contribution to the development of perinatal complications is speculated, two functional polymorphisms of the HMOX1 gene, (GT)n repeat polymorphism (rs3074372) and A(-413)T single nucleotide polymorphism (SNP) (rs2071746), were studied for their association with perinatal diseases. We systematically reviewed published evidence on HMOX1 polymorphisms in perinatal diseases and clarified their possible significant contribution to neonatal jaundice development, presumably due to their direct effect of inducing HO enzymatic activity in the bilirubin-producing pathway. However, the role of these polymorphisms seems limited for other perinatal complications such as bronchopulmonary dysplasia. We speculate that this is because the antioxidant or anti-inflammatory effect is not directly mediated by HO but by its byproducts, resulting in a milder effect. For better understanding, subtyping each morbidity by the level of exposure to causative environmental factors, simultaneous analysis of both polymorphisms, and the unified definition of short and long alleles in (GT)n repeats based on transcriptional capacity should be further investigated.

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Section: Association Between Ho-1 Gene Polymorphism and Clinical Diseasesmentioning

confidence: 99%

“…HO-1 gene promoter polymorphism has also been reported to be associated with neonatal hyperbilirubinemia ( 103 ), rheumatoid arthritis ( 12 , 104 ), pancreatitis ( 105 ), type II diabetes mellitus ( 106 ), heart disease ( 107 ) and other diseases to varying degrees. HO-1 carrying an S (GT)n repeat gene promoter was found to be associated with a higher risk of neonatal hyperbilirubinemia ( 103 ). By contrast, carrying the S (GT)n microsatellite allele was found to reduce the risk of rheumatoid arthritis and prevent the development of joint injury, whereas carrying the L (GT)n microsatellite allele led to an increase in the susceptibility to rheumatoid arthritis and promoted the development of joint injury ( 12 , 104 ).…”

Section: Association Between Ho-1 Gene Polymorphism and Clinical Diseasesmentioning

confidence: 99%

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Sun

Wang

et al. 2021

Mol Med Rep

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Heme oxygenase-1 (Ho-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin. These degradation products serve an important role in the regulation of inflammation, oxidative stress and apoptosis. While the expression level of Ho-1 is typically low in most cells, it may be highly expressed when induced by a variety of stimulating factors, a process that contributes to the regulation of cell homeostasis. in the 5'-non-coding region of the Ho-1 gene, there are two polymorphic sites, namely the (GT)n dinucleotide and T(-413)a single nucleotide polymorphism sites, which regulate the transcriptional activity of Ho-1. These polymorphisms have been shown to be closely associated with the occurrence and progression of numerous diseases, including cardiovascular, pulmonary, liver and kidney, various types of cancer and viral diseases. The present article reviews the progress that has been made in research on the association between the two types of polymorphisms and these diseases, which is expected to provide novel strategies for the diagnosis, treatment and prognosis of various diseases. Contents1. introduction 2. regulation of Ho-1 expression 3. Ho-1 promoter polymorphism 4. association between Ho-1 gene polymorphism and clinical diseases 5. conclusions and prospects

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Association between genetic polymorphism of heme oxygenase 1 promoter and neonatal hyperbilirubinemia: a meta-analysis

Cited by 10 publications

References 37 publications

Profiling of UGT1A16, UGT1A160, UGT1A193, and UGT1A128 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing

Profiling of UGT1A16, UGT1A160, UGT1A193, and UGT1A128 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing

The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

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Association between genetic polymorphism of heme oxygenase 1 promoter and neonatal hyperbilirubinemia: a meta-analysis

Cited by 10 publications

References 37 publications

Profiling of UGT1A1*6, UGT1A1*60, UGT1A1*93, and UGT1A1*28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing

Profiling of UGT1A1*6, UGT1A1*60, UGT1A1*93, and UGT1A1*28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing

The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

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Profiling of UGT1A16, UGT1A160, UGT1A193, and UGT1A128 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing

Profiling of UGT1A16, UGT1A160, UGT1A193, and UGT1A128 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing