Association Between Elevated C-Reactive Protein Levels and Prediabetes in Adults, Particularly Impaired Glucose Tolerance

Kato, Katsuhito; Otsuka, Toshiaki; Saiki, Yoshiyuki; Kobayashi, Nobuyuki; Nakamura, Takayuki; Konishi, Yoichi; Kawada, Tomoyuki

doi:10.1016/j.jcjd.2018.03.007

Cited by 29 publications

(22 citation statements)

References 34 publications

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“…While the exact mechanisms underlying the link between hs‐CRP and incident T2DM are still unclear, potential pathways may involve pancreatic β‐cells dysfunction and insulin resistance, 28,29 impaired glucose tolerance, 30 and endothelial cell functions 31 . Since our evidence was solely from observational studies, whether the association between hs‐CRP and T2DM was causal should be determined in other study types.…”

Section: Discussionmentioning

confidence: 99%

High‐sensitivity C‐reactive protein and risk of type 2 diabetes: A nationwide cohort study and updated meta‐analysis

Yang

Tao

Peng

et al. 2021

Diabetes Metabolism Res

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Objective To prospectively examine the association of high sensitivity C‐reactive protein (hs‐CRP) with incident type 2 diabetes mellitus (T2DM) among middle‐aged and elderly Chinese, and validate the association in an updated meta‐analysis of prospective studies. Methods We used data from the China Health and Retirement Longitudinal Study, started in 2011–2012 with follow ups in 2013–2014 and 2015–2016. Multivariable Cox proportional hazard regressions were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between hs‐CRP level and incident T2DM. An updated meta‐analysis was conducted to combine our estimates with those in previous prospective studies. Results Included in the analyses were 7985 participants (mean age: 59.38 years; men: 46.73%). Higher hs‐CRP was associated with increased risk of T2DM (multivariable‐adjusted HR, 1.30; 95% CI: 1.03, 1.64 for comparing extreme quartiles). The association was stronger in participants with body mass index (BMI) of 24.0 kg/m2 or higher than those with a BMI lower than 24.0 kg/m2 (p for interaction = 0.038). In a meta‐analysis of 28 cohorts, 2 case‐cohort, and 6 nested case‐control studies among 125,356 participants with 10,759 cases, the pooled relative risk for T2DM was 1.77 (95% CI: 1.60, 1.96) for the highest versus lowest level of hs‐CRP. Conclusions Hs‐CRP was associated with higher risk of T2DM in middle‐aged and elderly Chinese, and this association was confirmed by an updated meta‐analysis of prospective studies. Our findings highlight the role of elevated hs‐CRP in the development of T2DM.

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Section: Discussionmentioning

confidence: 99%

High‐sensitivity C‐reactive protein and risk of type 2 diabetes: A nationwide cohort study and updated meta‐analysis

Yang

Tao

Peng

et al. 2021

Diabetes Metabolism Res

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“…Biologic mechanisms underlying the associations of DII with prediabetes and IR remain unclear. Nonetheless, previous studies suggested that pro-inflammatory diet could promote low-grade inflammation (43) that is characterized by elevated proinflammatory markers, namely, CRP, TNF-a, and interleukin-6 which may lead to prediabetes and IR (44)(45)(46). Furthermore, high intakes of saturated fat and animal protein (47), which are the dietary constituents for DII calculation, may have adverse effects on prediabetes and IR (48).…”

Section: Discussionmentioning

confidence: 99%

Associations of Dietary Inflammatory Index With Prediabetes and Insulin Resistance

Shu

Wang

et al. 2022

Front. Endocrinol.

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Background and AimsPrevious studies suggested that dietary inflammatory index (DII) was associated with a variety of adverse health conditions. However, less is known about the role of DII in prediabetes and insulin resistance (IR). Therefore, this study aimed to investigate whether DII is associated with prediabetes and IR in American adults.Method and ResultsDII scores were calculated using the average of two 24-hour dietary recalls. Linear regression models were performed to evaluate the associations of DII with markers of Type 2 diabetes (T2D) risk, and the associations of DII with prediabetes and IR were estimated using logistic regression model. The diet of the participants showed an anti-inflammatory potential, with a mean DII score of −0.14 (range: −5.83 to +5.32). After controlling for multiple potential confounders, DII scores were positively associated with fasting plasma glucose (FPG) (β: 0.009; 95%CI: 0.005 to 0.012), fasting serum insulin (FSI) (β: 0.083; 95%CI: 0.067 to 0.099) and homeostatic model assessment of insulin resistance (HOMA-IR) (β: 0.092; 95%CI: 0.075 to 0.109). Participants in the highest tertile of DII score have increased odds of prediabetes (OR: 1.40; 95%CI: 1.17 to 1.69; P for trend <0.001) and IR (OR: 1.79; 95%CI: 1.49 to 2.14; P for trend <0.001) compared with those in the first tertile of DII score.ConclusionsThis study indicates that DII was positively associated with FPG, FSI, and HOMA-IR, and a more pro-inflammatory diet was related to increased odds of insulin resistant and prediabetes.

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“…It is known that subclinical inflammation and activated innate immunity have an important role in the pathophysiology of abnormal glucose metabolism [46, 47]. Studies with adults have shown risk of type 2 diabetes mellitus (DM2) development to be highly associated with increased CRP, suggesting that low-grade chronic inflammation coexists with glucose intolerance and compensatory increase in insulin secretion [48, 49]. Therefore, it is indicated that this inflammatory marker can be a powerful predictor of DM2 [47] and may be used to better target individuals for lifestyle interventions [46–50].…”

Section: Discussionmentioning

confidence: 99%

Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

Suhett

Hermsdorff

Rocha

et al. 2019

Cardiology Research and Practice

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C-reactive protein (CRP) is a marker of subclinical inflammation that has been found to be associated with cardiovascular disease risk. However, few studies have investigated the relationship between CRP and cardiometabolic markers in a representative sample of prepubescent children. The objective was to evaluate the high-sensitive CRP (hs-CRP) and its association with traditional and nontraditional cardiometabolic risk factors, as well as metabolic syndrome (MetS) components in Brazilian children. This is a cross-sectional representative study, with participants of the Schoolchildren Health Assessment Survey (PASE). Children from 8 to 9 years old (n=350) enrolled in public and private schools in the municipality of Viçosa, Minas Gerais, Brazil, were evaluated. Sociodemographic evaluation was performed through a semistructured questionnaire. Anthropometric, body composition, clinical, and biochemical measures were analyzed for cardiometabolic risk assessment. The total mean of serum hs-CRP concentration was 0.62 (±1.44) mg/L. hs-CRP was significantly correlated with several anthropometric, biochemical, and clinical parameters in this population (P<0.05). hs-CRP was positively associated with the accumulation of cardiometabolic risk factors and MetS components (P<0.05). Children with excessive weight; abdominal obesity; increased gynoid and android body fat; low HDL-c; hyperglycemia; and elevated uric acid, homocysteine, and apoB had higher chances of presenting increased hs-CRP (P<0.05). In this study, Brazilian children with cardiometabolic risk already presented elevated serum hs-CRP concentration. hs-CRP was associated with the increase of traditional and nontraditional cardiometabolic risk factors, as well as the accumulation of MetS components.

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Association Between Elevated C-Reactive Protein Levels and Prediabetes in Adults, Particularly Impaired Glucose Tolerance

Abstract: Elevated serum CRP levels are associated with prediabetes, particularly impaired glucose tolerance.

Cited by 29 publications

References 34 publications

High‐sensitivity C‐reactive protein and risk of type 2 diabetes: A nationwide cohort study and updated meta‐analysis

High‐sensitivity C‐reactive protein and risk of type 2 diabetes: A nationwide cohort study and updated meta‐analysis

Associations of Dietary Inflammatory Index With Prediabetes and Insulin Resistance

Increased C-Reactive Protein in Brazilian Children: Association with Cardiometabolic Risk and Metabolic Syndrome Components (PASE Study)

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