Association Between Duration of Reproductive Years and Metabolic Syndrome

Park, Yon Chul; Lee, Taesic; Kang, Hee-Taik; Cho, Eun Suk; Kim, Jai Soon; Hwang, Yoo Jung; Kim, Jong Koo

doi:10.1089/jwh.2017.6364

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…The associations between abdominal adipose tissue and brain characteristics are consistent with previous studies linking elevated adipose tissue to older brain age (Beck et al, 2022;Subramaniapillai et al, 2022), lower brain volume (Cho et al, 2021;Debette & Markus, 2010;Gurholt et al, 2021;Isaac et al, 2011;Veit et al, 2014), and higher WMH load (Arnoldussen et al, 2019;Lampe et al, 2019;Park et al, 2018;Vuorinen et al, 2014). The relationships were strongest for WMH volume, suggesting that brain white matter may be particularly sensitive to elevated abdominal adipose tissue in post-menopausal females.…”

Section: Discussionsupporting

confidence: 88%

“…The relationships between oestrogen exposure, body composition, and brain health in females are complex and largely unexplored. The menopause transition is linked to an accelerated increase of central fat accumulation (Lizcano & Guzmán, 2014), and abdominal adipose tissue has been associated with higher grey matter (GM) and white matter (WM) brain age (Beck et al, 2022(Beck et al, , 2021bSubramaniapillai et al, 2022), WM hyperintensities (WMH) (Arnoldussen et al, 2019;Han et al, 2021;Lampe et al, 2019;Pasha et al, 2017;Park et al, 2018;Vuorinen et al, 2014), and dementia risk (Kiliaan et al, 2014;Tang et al, 2021;Razay et al, 2006;Whitmer et al, 2008). However, in females, adipose tissue also serves as the primary biosynthesis site of oestrogens post-menopause (Steiner & Berry, 2022;Bhardwaj et al, 2019;Kershaw & Flier, 2004;Siiteri, 1987;Simpson, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Schindler¹,

Subramaniapillai²,

Barth³

et al. 2022

Preprint

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The menopause transition involves changes in oestrogens and adipose tissue distribution, which may influence female brain health post-menopause. Although increased central fat accumulation is linked to risk of metabolic diseases, adipose tissue also serves as the primary biosynthesis site of oestrogens post-menopause. It is unclear whether different types of adipose tissue play diverging roles in female brain health post-menopause, and whether this depends on lifetime oestrogen exposure, which can have lasting effects on the brain and body even after menopause. Using the UK Biobank sample, we investigated associations between brain characteristics and visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) in 10,251 post-menopausal females, and assessed whether the relationships varied depending on length of reproductive span (age at menarche to age at menopause). To parse the effects of common genetic variation, we computed polygenic scores for reproductive span. The results showed that higher VAT and ASAT were both associated with higher grey and white matter brain age, and greater white matter hyperintensity load. The associations varied positively with reproductive span, indicating more prominent associations between adipose tissue and brain measures in females with a longer reproductive span. The results could not be fully explained by genetic variation or relevant confounders. Our findings indicate that associations between abdominal adipose tissue and brain health post-menopause may partly depend on individual differences in cumulative oestrogen exposure during reproductive years, emphasising the complexity of neural and endocrine ageing processes in females.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Schindler¹,

Subramaniapillai²,

Barth³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Furthermore, in menopausal women, lipoprotein lipase activity was reported to increase in both the abdominal and the gluteal regions, inducing fat accumulation in the form of intramuscular fat [30][31][32]. This might lead to a higher risk for metabolic syndrome in postmenopausal women with a short duration of reproductive span [33]. Recently, Shin and Kwon reported that a short reproductive span had a causal relationship with increased risk of insulin resistance [34].…”

Section: Discussionmentioning

confidence: 99%

“…Direct evidence of the protective effect of estrogen was provided in an animal model, in which 17 β-estradiol administered parenterally to ovariectomized monkeys resulted in 50-70% decreases in coronary artery atherosclerosis [35]. The mechanism underlying the protective effects of estrogen on vessels has been reported to involve fibroblast growth factor-2, vascular endothelial growth factor, and nitric oxide synthesis [36][37][38], and recently, reproductive span was demonstrated to be inversely related to cardiovascular disease [39] and metabolic syndrome [33]. We cautiously suggest that these findings and our finding that reproductive span is significantly and inversely association with sarcopenia indicate that a lack of estrogen and systemic and vessel inflammation underlie these associations.…”

Section: Discussionmentioning

confidence: 99%

Association between Reproductive Span and Sarcopenia

Park

Han

Chung

et al. 2020

IJERPH

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Sarcopenia is defined as an age-related loss of skeletal muscle and is associated with several health disorders. Causes of sarcopenia, which included physical inactivity, alcohol, dietary habits, and smoking, have been researched. The present study was undertaken to examine the association between reproductive span and sarcopenia in Korean women. Data obtained from 2008 to 2011 Korea National Health and Nutrition Examination Surveys (KNHANES) were analyzed. We defined sarcopenia based on the cut-off values of the Foundation for the National Institutes of Health (FNIH) sarcopenia project criteria: ASM/BMI < 0.512 for women. Reproductive span was defined as years from menarche to menopause, and we divided the 3970 study subjects into three groups by reproductive span tertile. Multivariate logistic regression analysis was used to determine adjusted ORs for the relation between reproductive span and sarcopenia. The prevalence of sarcopenia in the study was 17.7% (704 of 3970). Multiple logistic regression analysis was performed using weighted populations. After adjusting for covariates, reproductive span was found to be inversely associated with the risk of sarcopenia [Tertile 1 = 1 (reference); Tertile 2, odds ratio (OR) = 0.927, 95% confidence interval (CI) = 0.863–0.995; Tertile 3, OR = 0.854, 95% CI = 0.793–0.915].

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“…Too short or too long, a childbearing period can increase a woman's risk of developing diabetes. Studies have also shown that the long childbearing period was a simple positive correlation with the risk of diabetes ( 9 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Number of Births and Risk of Diabetes in China's Older Women

Zhang

Wang

et al. 2022

Front. Med.

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As an important life event in individuals' life, childbirth will affect the health of women to different degrees. More and more attention has been paid to whether the number of births will affect the incident diabetes in elderly women, but there are few related studies. Based on the data of the Chinese Longitudinal Healthy Longevity Survey in 2018, 6,159 older women are selected as the study population. Logistic regression analyses are used to estimate the relationship between the number of births and diabetes risk. For each additional birth, the odds ratio of maternal diabetes will decrease by 6.9% and the result is significant at the 1% level, especially among mothers having four children or less. The conclusion is equally applicable in the sample of fathers and urban mothers, but the increase in the number of births will increase the risk of diabetes in rural mothers, although this result is not statistically significant. Later age at first birth, later age at last birth, the longer childbearing period, and birth interval will significantly reduce the risk of diabetes.

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Association Between Duration of Reproductive Years and Metabolic Syndrome

Abstract: Longer reproductive years were significantly associated with a decreased prevalence of MetS.

Cited by 9 publications

References 38 publications

Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Association between Reproductive Span and Sarcopenia

Number of Births and Risk of Diabetes in China's Older Women

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