Association between Cardiorespiratory Fitness, Relative Grip Strength with Non-Alcoholic Fatty Liver Disease

Hao, Li; Wang, Zhengzhen; Wang, Yan; Wang, Juan; Zeng, Zhipeng

doi:10.12659/msm.923015

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…In addition, an examination in this study of the relative risk of NAFLD in consideration of both CRF and MS showed that the relative risk of low CRF/MS was 2.27-fold higher than that of high CRF/MS. This result corresponds to the finding of Hao et al [28] where, among adult men, the risk of NAFLD decreased as VO 2 max (>30 mL/kg −1 min −1 ) and MS levels increased. This result indicates that a decrease of CRF and MS, both of which are regarded as being important in adult health and fitness, increases the risk of NAFLD.…”

Section: Discussionsupporting

confidence: 91%

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Association between Cardiorespiratory Fitness, Muscle Strength, and Non-Alcoholic Fatty Liver Disease in Middle-Aged Men

Kang¹,

Park²,

Ha³

et al. 2022

JOMH

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Background: Nonalcoholic fatty liver disease (NAFLD) occurs when more than 5% of fat accumulates in the liver parenchyma without excess alcohol consumption. The objective of this study is to investigated the association between cardiorespiratory fitness (CRF), muscle strength (MS), and NAFLD. Methods: The subjects of this study were 1325 males aged 40-50 who had visited the National Fitness Center located in the Republic of Korea from 2017 to 2019. Abdominal ultrasonography testing was used for NAFLD diagnosis. For CRF, an MS test was used to measure maximal oxygen intake and grip strength. CRF and MS were classified into 3 quartiles (high, middle, low-level). In addition, both the CRF level and MS level were classified into 9 quadrants. Results: With confounding factors (age, body mass index, exercise, smoking) controlled, there was no relative risk of NAFLD between middle and high levels of CRF (95% CI, 0.92-2.17). However, the relative risk of NAFLD in the case of low-level CRF was 1.63-fold (95% CI, 1.03-2.60, p < 0.05) higher than that in the case of high-level CRF. Meanwhile, there was no significant difference between middle-level MS (95% CI, 0.68-1.65) and high-level MS (95% CI, 0.84-1.99) in terms of NAFLD relative risk. The NAFLD relative risk in the case of low-level CRF/MS was 2.27-fold (95% CI, 0.94-1.99, p < 0.05) higher than that of high-level CRF/MS. Conclusions: The low CRF and MS group had a higher risk of NAFLD compared with the high CRF and MS group. Maintenance of high CRF and MS may be beneficial in preventing NAFLD.

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Section: Discussionsupporting

confidence: 91%

“…While the cause of NAFLD is not certain, obesity and insulin resistance are two highly influential factors [26,27]. It is also reported that there is a positive effect from CRF and MS [28]. In this study, CRF and MS were classified into 3 quartiles.…”

Section: Discussionmentioning

confidence: 89%

Association between Cardiorespiratory Fitness, Muscle Strength, and Non-Alcoholic Fatty Liver Disease in Middle-Aged Men

Kang¹,

Park²,

Ha³

et al. 2022

JOMH

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“…Recently, many studies have suggested that muscle strength is a more precise indicator than muscle mass for predicting health outcomes [8]. Nevertheless, few studies on the association between muscle strength and NAFLD have been reported [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…A previous study demonstrated that relative handgrip strength is associated with metabolic diseases [18]. However, there are few studies that examine relative handgrip strength and NAFLD [10,19].…”

Section: Introductionmentioning

confidence: 99%

Association of Muscle Strength with Non-Alcoholic Fatty Liver Disease in Korean Adults

Lee

Kwon

Jung

et al. 2022

IJERPH

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Sarcopenia is known to be associated with non-alcoholic fatty liver disease (NAFLD). However, few studies have revealed the association between muscle strength and prevalence of NAFLD. We investigated the association by using relative handgrip strength in a nationwide cross-sectional survey. The participants were recruited from the Korean National Health and Nutrition Examination Surveys (KNHANES). A total of 27,531 subjects from the KNHANES were selected in our study. We used normalized handgrip strength, which is called relative handgrip strength. The index was defined as handgrip strength divided by BMI. These subjects were divided into quartile groups according to relative handgrip strength. NAFLD was defined as hepatic steatosis index >36. Multinomial logistic regression was analysed to investigate the association between relative handgrip strength with prevalence of NAFLD. The mean age of study population was 45.8 ± 0.3 in men, and 48.3 ± 0.2 in women. The proportion of males was 37.5%. In multiple linear regression, relative handgrip strength was inversely associated with HSI index (Standardized β = −0.70; standard error (SE), 0.08; p < 0.001 in men, Standardized β = −0.94; standard error (SE), 0.07; p < 0.001 in women). According to the logistic regression model, the prevalence of NAFLD decreased with quartile 4 groups in relative handgrip strength, compared with quartile 1 groups (OR 0.42 [0.32–0.55] in men; OR 0.30 [0.22–0.40] in women). Relative handgrip strength, used as a biomarker of sarcopenia, is independently inversely associated with NAFLD.

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“…Prior studies have shown that GS adjusted for the body surface area may moderately reflect CRF levels in healthy young adults ( 12 ). Furthermore, many studies observed parallel changes between the GS and CRF value in the course of the diseases like diabetes ( 34 ), liver disease ( 35 ), cardiovascular disease ( 36 ), common mental disorders ( 37 ), and cancer ( 38 ). However, to our knowledge, no prior studies have reported the level and further relationship between each other of these indicators mentioned above in patients with mild acute ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Exploring Alternative Measurements of Cardiorespiratory Fitness in Patients With Mild Ischemic Stroke at Acute Phase

Zhu

Wang

et al. 2022

Front. Neurol.

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BackgroundWhile emerging studies have suggested an association of cardiorespiratory fitness (CRF) with stroke risk and overall health outcomes, little is known regarding the optimum methods of CRF measurement in patients with mild acute ischemic stroke.ObjectiveThe aim of this study was to explore the association between the 6-min walk distance (6MWD) and other measurements related to CRF in patients with mild ischemic stroke at the acute stage.MethodsA total of 30 patients with stroke and 71 healthy subjects matched for age and grip strength (GS) were prospectively recruited. All patients were within 14 days after stroke onset and presented mild motor impairment (with a full score of Fugl-Meyer Motor Assessment). Demographic data of both groups and clinical information of the stroke group were documented, and the CRF comparison between the two groups was conducted. Each participant underwent a one-time assessment of 6MWD and a series of measurements related to CRF, including GS, 10-m walk test (10mWT), five-times sit-to-stand time (FTSST), functional reaching test (FRT), Berg Balance Scale (BBS), and waistline. Pearson's product-moment correlation coefficient test and multiple linear regression were performed to explore the indicators of CRF.ResultsSignificant moderate correlations (0.3 < r <0.6) were found between 6MWD and GS of left hand (GS-left) (r = 0.573, p = 0.001), GS of right hand (GS-right) (r = 0.524, p = 0.003), FTSST (r = −0.551, p = 0.002), 10mWT (r = 0.554, p = 0.001), and FRT (r = 0.449, p = 0.021) in the patient group. While 6MWD displayed significant moderate correlations with waistline (r = 0.364, p = 0.002), 10mWT (r = 0.512, p < 0.001), FTSST (r = −0.573, p < 0.001), and FRT (r = 0.550, p < 0.001) in the healthy group. All these dependent variables were entered into a stepwise multiple linear regression analysis to evaluate their values in estimating CRF as measured by 6MWD in each group. Analyses suggested that GS-left (p = 0.002) and FTSST (p = 0.003) were the indicators of CRF in the patient group with stroke and explained 51.4% of the variance of 6MWD (R2 = 0.514); FTSST (p < 0.001), 10mWT (p < 0.001), and FRT (p = 0.021) were the indicators of CRF in the healthy group and explained 58.9% of variance of 6MWD (R2 = 0.589).ConclusionsOur data confirmed that CRF is impaired in patients with mild ischemic stroke at the acute phase. Moreover, GS-left may be an optional indicator of CRF in patients with mild acute ischemic stroke, but not in healthy people.Clinical Trial Registrationwww.chictr.org.cn, identifier: ChiCTR2000031379.

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Association between Cardiorespiratory Fitness, Relative Grip Strength with Non-Alcoholic Fatty Liver Disease

Cited by 10 publications

References 36 publications

Association between Cardiorespiratory Fitness, Muscle Strength, and Non-Alcoholic Fatty Liver Disease in Middle-Aged Men

Association between Cardiorespiratory Fitness, Muscle Strength, and Non-Alcoholic Fatty Liver Disease in Middle-Aged Men

Association of Muscle Strength with Non-Alcoholic Fatty Liver Disease in Korean Adults

Exploring Alternative Measurements of Cardiorespiratory Fitness in Patients With Mild Ischemic Stroke at Acute Phase

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