Association of Muscle Strength with Non-Alcoholic Fatty Liver Disease in Korean Adults

Lee, Sung-Bum; Kwon, Yu‐Jin; Jung, Dong-Hyuk; Kim, Jong Koo

doi:10.3390/ijerph19031675

Cited by 11 publications

(14 citation statements)

References 49 publications

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“…Emerging studies have explored the relationships between skeletal muscle mass and NAFLD, hepatic steatosis, as well as significant liver fibrosis (8, 9, 20-23). However, most of them used less accurate surrogate measures, such as handgrip strength (8,9,22) and fatty liver index (23). Leveraging data from the Korean National Health and Nutrition Examination Surveys (KNHANES), Lee Sung-Bum found that handgrip strength was inversely associated with HSI, and the prevalence of NAFLD defined by HSI decreased in the quartile groups of handgrip strength (9).…”

Section: Discussionmentioning

confidence: 99%

“…However, most of them used less accurate surrogate measures, such as handgrip strength (8,9,22) and fatty liver index (23). Leveraging data from the Korean National Health and Nutrition Examination Surveys (KNHANES), Lee Sung-Bum found that handgrip strength was inversely associated with HSI, and the prevalence of NAFLD defined by HSI decreased in the quartile groups of handgrip strength (9). Being partially consistent with our results, they also observed that the risk for NAFLD in females (OR[95%CI]: 0.30 [0.22-0.40]) was more relevant to muscle strength than that in males MAFLD, metabolic dysfunction-associated fatty liver disease; SMI, skeletal muscle mass index; OR, odds ratio; CI, confidence interval.…”

Section: Discussionmentioning

confidence: 99%

“…As an endocrine organ, skeletal muscle can secrete myokines that might affect the function of the liver (7). Nevertheless, the relationships between skeletal muscle mass and NAFLD were estimated only by a limited number of studies and using less accurate surrogate measures, such as handgrip strength and hepatic steatosis index (HSI) (8,9). Moreover, the effects of regional skeletal muscle distribution on MAFLD and the differences between sexes are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease

Xiao

Gao

et al. 2022

Front. Endocrinol.

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IntroductionMetabolic dysfunction-associated fatty liver disease (MAFLD) is known to be the most common chronic liver disease worldwide, and accumulating evidence suggests that skeletal muscle might play an important role in metabolic health. However, the association between skeletal muscle and MAFLD is poorly understood so far. Therefore, we aimed to evaluate the associations of skeletal muscle with MAFLD and significant fibrosis.MethodsA cross-sectional analysis was conducted using data obtained from the 2017-2018 US National Health and Nutrition Examination Survey. The whole-body, appendicular, and trunk skeletal muscle mass index (SMI) were assessed by dual-energy x-ray absorptiometry. MAFLD and significant fibrosis were assessed by transient elastography. Survey-weight adjusted multivariable logistic regressions were used to determine the associations. The area under the receiver operating characteristic curve (AUC) and variable importance scores from the random forest and logistic regression model were calculated to assess the predictive capability of variables and models.ResultsOf the 2065 participants, those with appendicular SMI in the highest quartile were associated with a lower risk for MAFLD in both sexes (male, OR[95%CI]: 0.46 [0.25~0.84]; female, OR[95%CI]: 0.32 [0.13~0.82]), but with a significantly different scale of the associations between sexes (Pinteraction = 0.037). However, females with trunk SMI in the highest quartile had an increased risk of significant fibrosis (OR[95%CI]: 7.82 [1.86~32.77]). Trunk SMI and appendicular SMI ranked the third contributor to MAFLD in random forest and logistic regression models, respectively. Taking appendicular and trunk SMI into consideration, the AUCs for MAFLD were 0.890 and 0.866 in random forest and logistic regression models, respectively.DiscussionThe distribution of skeletal muscle mass differently affects MAFLD and significant fibrosis in the sex groups. Higher appendicular skeletal muscle mass was associated with a lower risk of MAFLD, while the risk of significant fibrosis in females was increased with the trunk skeletal muscle mass.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease

Xiao

Gao

et al. 2022

Front. Endocrinol.

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“…Ten articles were included in this analysis (Figure 1) (9,(24)(25)(26)(27)(28)(29)(30)(31)(32). The selected studies involved 76,676 participants.…”

Section: Eligible Studies and Individual Characteristicsmentioning

confidence: 99%

Association between grip strength and non-alcoholic fatty liver disease: A systematic review and meta-analysis

Liu

et al. 2022

Front. Med.

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BackgroundThe association between grip strength (GS) and non-alcoholic fatty liver disease (NAFLD) has been reported by recent epidemiological studies, however, the results of these studies are inconsistent. This meta-analysis was conducted to collect all available data and estimate the risk of NAFLD among people with low GS, as well as the risk of low GS among patients with NAFLD.MethodsWe systematically searched several literature databases including PubMed, Web of Science, Cochrane Library, and Embase from inception to March 2022. These observational studies reported the risk of NAFLD among people with low GS and/or the risk of low GS among patients with NAFLD. Qualitative and quantitative information was extracted, statistical heterogeneity was assessed using the I2 test, and potential for publication bias was assessed qualitatively by a visual estimate of a funnel plot and quantitatively by calculation of the Begg’s test and the Egger’s test.ResultsOf the citations, 10 eligible studies involving 76,676 participants met inclusion criteria. The meta-analysis of seven cross-section studies (69,757 participants) showed that people with low GS had increased risk of NAFLD than those with normal GS (summary OR = 3.32, 95% CI: 1.91–5.75). In addition, the meta-analysis of four studies (14,920 participants) reported that the risk of low GS patients with NAFLD was higher than those in normal people (summary OR = 3.31, 95% CI: 2.45–4.47).ConclusionIn this meta-analysis, we demonstrated a strong relationship between low GS and NAFLD. We found an increased risk of NAFLD among people with low GS, and an increased risk of lower GS among NAFLD patients.Systematic review registration[www.crd.york.ac.uk/prospero], identifier [CRD42022334687].

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“…Handgrip strength is an inexpensive and simple assessment tool to measure muscle strength and is suitable for the diagnosis of sarcopenia [ 7 ]. Previous studies found handgrip strength to be a predictor of non-alcoholic fatty liver disease and healthy aging [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Handgrip Strength with Diabetes Mellitus in Korean Adults According to Sex

2022

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Diabetes mellitus (DM) is known to lead to many diseases such as cardiovascular disease and chronic kidney diseases. Therefore, it is essential to find diagnostic tools to prevent DM. This study aimed to find the association between handgrip strength and the prevalence of diabetes mellitus (DM) in Korean adults with respect to sex and menopause. A total of 26,536 participants (12,247 men, 6977 premenopausal women, and 7312 postmenopausal women) aged >19 years were recruited. The study population was divided into quartiles of relative handgrip strength. Logistic regression was used to analyse the association between relative handgrip strength and the prevalence of DM. Compared with the lowest quartile, the odds ratio (95% confidence interval (CI)) the prevalence of DM for the fourth quartile (Q4) was 0.57 (0.43–0.75) after adjusting for confounding factors in men; 0.33 (0.14–0.75), premenopausal women; and 0.82 (0.63–1.07), postmenopausal women. The prevalence of DM decreased as relative handgrip strength increased. This inverse association was more significant in men and premenopausal women than that in postmenopausal women.

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Association of Muscle Strength with Non-Alcoholic Fatty Liver Disease in Korean Adults

Cited by 11 publications

References 49 publications

Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease

Sex- and region-specific associations of skeletal muscle mass with metabolic dysfunction-associated fatty liver disease

Association between grip strength and non-alcoholic fatty liver disease: A systematic review and meta-analysis

Association of Handgrip Strength with Diabetes Mellitus in Korean Adults According to Sex

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