Association Between C Reactive Protein and Asthma

Abstract

Amaç: Yapılan çalışmalar sistemik inflamasyon belirteçleri ve akciğer fonksiyonları arasında ters bir orantı olduğunu göstermekte-dir. Bu çalışmada C-reaktif proteinin (CRP) serum düzeyi, vücut kitle indeksi ve astım arasındaki ilişkiyi belirlemeyi hedefledik. Gereç ve Yöntem:Bu çalışmada 178 astım hastasında ve 50 sağlıklı kontrol grubunda CRP düzeyi belirlendi. Astım hastaları-nın 126'sı stabil evrede ve 52'si ise atak dönemindeydi. Bulgular:Astım hastalarında kontrol grubuna göre CRP düzeyi-nin istatistiksel düzeyde anlamlı derecede (p<0.05) daha yüksek olduğu görüldü. Atak dönemindeki astım hastalarında ise serum CRP düzeylerinin stabil devredeki astım hastalarından anlamlı derecede daha yüksek olduğu görüldü (p<0.05). Astım hastalarında FEV1 değeri serum CRP düzeyi ile ters bir orantı gösteri-yordu. Astım hastalarında, serum CRP düzeyi ve vücut kitle indeksi arasında istatistiksel düzeyde anlamlı bir ilişki vardı (p<0.0001). Ayrıca ortalama vücut kitle indeksinin astım hastalarında kontrol gruba göre daha yüksek olduğu görüldü. Material and Method:In the present study, CRP was determined in 178 patients with asthma and 50 healthy control subjects. Of all asthmatics, 126 had stable asthma and 52 had asthma during exacerbation.Results: CRP was significantly higher (p<0.05) in asthmatic patients as compared to the control group. In asthmatics with exacerbation, serum CRP was significantly higher than in stable asthmatic patients and control subjects. FEV1 was significantly inversely correlated with serum CRP in asthmatic patients. In asthmatic patients there was a significant (p<0.0001) association between serum level of CRP and body mass index. Furthermore, the mean BMI was significantly higher in asthmatic patients than that in control subjects. Conclusion:Serum CRP may be a non specific marker of asthma and its exacerbation. In addition, obesity could be a risk factor for asthma. (Tur Toraks Der 2010; 11: 98-104)

The use of biomarkers to predict attacks of sever bronchial asthma and chronic obstructive pulmonary disease

“…In COPD group, fibrinogen mean was 583.24±70 mg/dL, which was significantly higher than control group (P-value ≤ 0.001) which agreed with a cohort study conducted by Mannino et al, 2015. In asthmatic group, CRP mean was 10.2 mg/L and significantly higher than control group (P ˂ 0.05) which agreed with findings of Obaidi et al, 2010. In COPD group, CRP mean was 14.2 mg/L, which was significantly higher than control group which agreed with finding of Fattouh & Alkady, (2014). A similar findings of Thomsen et al and Aksu et al, 2013 supports that CRP level is significantly higher in COPD.…”