The use of biomarkers to predict attacks of sever bronchial asthma and chronic obstructive pulmonary disease

Abstract

Introduction: Increased levels of C-reactive protein (CRP) and fibrinogen among asthmatic and Chronic Obstructive Pulmonary Disease (COPD) patients were associated with disease severity and complications. Aim of the work:To assess the possible relationship between selected variables and hospitalization as unfavorable outcome. Subjects and methods: 172 subjects had participated in this observational study and grouped into three groups; control, asthmatic and COPD. Blood analysis used for fibrinogen and CRP levels and pulmonary function were measured. Statistical analysis using t-test, ROC, and regression test in order to assess the predictive potential of those variables. Results: mean of fibrinogen among COPD group (583.24 mg/dL) was significantly higher than control (207 mg/dL), (P<0. 001). Mean of CRP (14.2 mg/L) was significantly higher than control (0.98 mg/L), (P<0.001). Mean of fibrinogen among asthmatic group (414.8 mg/dL) was significantly higher than control (207 mg/dL). Mean of CRP (10.2 mg/L) was significantly higher than control (0.98 mg/dL). Statistically significant inverse correlation was found between fibrinogen and ratio of Forced Expiratory Volume in the first second (FEV1) to full Forced Vital Capacity (FVC) this ratio is expressed as FEV% (r=-0.885). Also, an inverse correlation between CRP and FEV% (r=-.75). ROC analysis suggested cut score for fibrinogen at 445 mg/dL, 370 mg/dL for COPD and asthmatic groups respectively, while CRP

Serum YKL-40 Levels in Patients with Asthma or COPD: A Pilot Study

“…El-Shoubargy et al (2021) investigated the relevance of different blood-based biomarkers for BA and COPD. This study yielded similar results, with the measured values for these respiratory conditions being higher than those determined for healthy controls [ 34 ]. Growing evidence supports the existence of a concentration-dependent, significant association between elevated circulating fibrinogen levels and diminished lung function, increased risk of COPD development and exacerbation, and higher declines in FEV 1 /FVC ratio in elderly cohorts [ 35 , 36 , 37 , 38 ].…”