Association Between Bacteremia Due to Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis I) and Colorectal Neoplasia: A Case-Control Study

Abstract

The frequency of CRN among SGG infected patients is significantly increased compared with symptomatic age-matched controls, indicating that SGG infection is a strong indicator for underlying occult malignancy.

Differences between endocarditis caused by Streptococcus bovis and Enterococcus spp. and their association with colorectal cancer

“…Thus, the results might be different if systematic colonoscopy had been performed in both groups; further studies are required to clarify these questions. Despite these limitations, our data strongly suggest that the percentage of CRN is higher in patients diagnosed with Sb IE than in the general population [29].…”

“…In our area, we found an increase not only in the number of cases, but also in the percentage of older patients (>65 years), which was 22 % in 1991 and 28 % in 2011. In addition, we had previously reported a high incidence of CRN [29]. CRN increases notably with aging, which may partially explain this high incidence of IE caused by microorganisms with intestinal ns not significant niche [30].…”

The clinical epidemiology and malignancies associated with Streptococcus bovis biotypes in 506 cases of bloodstream infections

“…However, the proportion of carcinomas was similar in Sb-I and Sb-II cases (around 8e9%) ( Table 3) and, importantly, these rates were higher than in asymptomatic general population undergoing colonoscopy (around 0.5%e1%) 48 ; CRN associated with Sb-II were often advanced carcinomas and had been diagnosed before the episode of bacteraemia. Some reports have suggested that intestinal microbiota may play a role in the development of CRN.…”

Streptococcusviridians bacteraemia and colonic adenocarcinoma

“…Since the first article in 19511 that suggested a correlation between S. bovis and colonic neoplasm, there has been growing evidence that established this correlation, identified both on clinical2 – 4 and laboratory studies 5 – 7…”

“…Over the years, there has been growing evidence supporting the relationship between Streptococcus bovis and colonic malignancies 1 2. The scope of the evidence is also expanding in the association with other gastrointestinal neoplasms and liver disease 3 4.…”