Streptococcusviridians bacteraemia and colonic adenocarcinoma

Abstract

Even thoughStreptococcusbacteraemia is an infrequent presentation of colonic malignancies, there is a well-established link betweenStreptococcus bovisbacteraemia and colonic malignancies. Most of the physicians are well aware of this correlation and further workup is pursued in most of the cases. However, many physicians may not be aware that other species ofStreptococcusviridians, other thanS. bovis, can be associated with colonic malignancies. In this case report, we present a case ofStreptococcusviridians (anginosus) bacteraemia as a complication of an undiagnosed sigmoid adenocarcinoma. While further evidence is needed to warrant a gastrointestinal (GI) workup in a patient with other species ofStreptococcusviridians bacteraemia, we would like to increase the awareness in the physicians’ community regardingStreptococcusviridians, other thanS. bovisbacteraemia. This would be especially relevant for patients who have no GI screening, asStreptococcusviridians bacteraemia can be an early sign of colonic neoplasm.

Metagenomic analysis of primary colorectal carcinomas and their metastases identifies potential microbial risk factors

“…The bacterial species we observed enriched, or exclusively, in primary colorectal carcinomas have been reported to show oncogenic or pro‐inflammatory potential. Our tumour‐specific findings of F. nucleatum , S. anginosus and F. alocis , S. sanguinis , P. micra and Gemella oral taxon 928 confirm the results of other research groups [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ]. In particular, a recent microbiome analysis of CRC tissues found the species F. nucleatum , S. anginosus and S. sanguinis at high prevalence in cancer tissues (false discovery rate lower than 10 5 ) [ 81 ].…”

Second look atStreptococcus sanguinisand the colon

“…In this case report, the discovery of S. sanguinis bacteraemia led to the discovery and removal of a large colonic mass with high-grade dysplasia. While colonoscopy has become the standard of care for S. bovis/gallolyticus bacteraemia, several authors have made the case that other viridans species merit similar vigilance 4. Eight cases of S. sanguinis bacteraemia associated with occult gastrointestinal malignancy have been previously reported.…”