The clinical epidemiology and malignancies associated with Streptococcus bovis biotypes in 506 cases of bloodstream infections

Corredoira, Juan; Grau, Inmaculada; García-Rodríguez, José Francisco; Alonso-García, Pilar; García-Pais, María-José; Rey, Ramón Rabuñal; Garcı́a-Garrote, Fernando; Ardanuy, Carmen; Coira, Amparo; López-Álvarez, María; Pallarés, Román

doi:10.1016/j.jinf.2015.05.005

Cited by 35 publications

(20 citation statements)

References 44 publications

(32 reference statements)

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“…Among these different species, Sg infection has the strongest association with CRC (~ 7 fold higher risk compared to infections caused by the other species), suggesting the existence of a Sg -specific mechanism(s) that promotes the association between the pathogen and CRC. Other similar studies consistently revealed elevated risks of colorectal adenoma/carcinoma for patients with Sg infections [14,21–25,32]. These epidemiological studies clearly show a strong association between Sg bacteremia/endocarditis and CRC.…”

Section: Introductionsupporting

confidence: 71%

Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development

et al. 2017

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Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong association with colorectal cancer (CRC). This knowledge has important clinical implications, and yet little is known about the role of Sg in the development of CRC. Here we demonstrate that Sg promotes human colon cancer cell proliferation in a manner that depends on cell context, bacterial growth phase and direct contact between bacteria and colon cancer cells. In addition, we observed increased level of β-catenin, c-Myc and PCNA in colon cancer cells following incubation with Sg. Knockdown or inhibition of β-catenin abolished the effect of Sg. Furthermore, mice administered with Sg had significantly more tumors, higher tumor burden and dysplasia grade, and increased cell proliferation and β-catenin staining in colonic crypts compared to mice receiving control bacteria. Finally, we showed that Sg is present in the majority of CRC patients and is preferentially associated with tumor compared to normal tissues obtained from CRC patients. These results taken together establish for the first time a tumor-promoting role of Sg that involves specific bacterial and host factors and have important clinical implications.

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Section: Introductionsupporting

confidence: 71%

Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development

et al. 2017

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“…Joined together with living in the countryside, a close contact with animals was supposed to be a transmission source of the bacterium [8,14], it was demonstrated for the first time that a closer contact with animals is a significant exposure factor to be colonized with S . gallolyticus subsp.…”

Section: Discussionmentioning

confidence: 99%

Case-control study: Determination of potential risk factors for the colonization of healthy volunteers with Streptococcus gallolyticus subsp. gallolyticus

et al. 2017

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Streptococcus gallolyticus subsp. gallolyticus was identified in humans and animals as commensal of the gut and can act as a causative agent of endocarditis and septicemia. A case-control study was performed to identify yet unknown risk factors for the transmission of this facultative pathogen. The prevalence in the gut of 99 healthy volunteers was determined using real-time polymerase chain reaction resulting in 62.5% S. gallolyticus subsp. gallolyticus positive excrements. Subsequent cultivation offered three isolates and epidemiological analysis based on MLST revealed sequence type (ST) 3 and ST 7, previously detected from bovine and endocarditis patients. These results support the hypotheses of the zoonotic potential of this bacterium. Participant questionnaires were evaluated concerning personal characteristics, nutritional habits and animal contact. Specifically, closer contact between participants and animals influenced the colonization of the human gut significantly and was further affected if volunteers used excrement for the fertilization of plants.

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“…CRC is associated with a number of environmental factors including: age above 50 years, smoking, drinking alcohol, obesity, consumption of saturated fats and red meat ( Joint WHO/FAO expert consultation group, 2003 ). Microorganisms such as members of the Streptococcus bovis/Streptococcus equinus complex (SBSEC) have also been associated with CRC ( Ben-Chetrit et al, 2017 , Boleij and Tjalsma, 2013 , Corredoira et al, 2015 ). Despite this association, some SBSEC members are also given commensal status in the gastrointestinal tract of humans and animals, while recent studies have even shown that traditional fermented dairy products (tFDP) in Africa are predominated by Streptococcus infantarius subsp.…”

Section: Introductionmentioning

confidence: 99%

Investigating the association between African spontaneously fermented dairy products, faecal carriage of Streptococcus infantarius subsp. infantarius and colorectal adenocarcinoma in Kenya

Kaindi

Kogi-Makau

et al. 2018

Acta Tropica

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The clinical epidemiology and malignancies associated with Streptococcus bovis biotypes in 506 cases of bloodstream infections

Cited by 35 publications

References 44 publications

Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development

Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development

Case-control study: Determination of potential risk factors for the colonization of healthy volunteers with Streptococcus gallolyticus subsp. gallolyticus

Investigating the association between African spontaneously fermented dairy products, faecal carriage of Streptococcus infantarius subsp. infantarius and colorectal adenocarcinoma in Kenya

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