Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis

Polat, Cahit; Düzer, Sertaç; Ayyıldız, Hakan; Sec, Semih; Aksoy, Neval; Sakallıoğlu, Öner; Akyiğit, Abdulvahap; Çetiner, Hasan

doi:10.5152/tao.2018.3242

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…Results from the factor analysis demonstrated that a bi-factor model, with all items loading onto general factor with two group factors, provides the best fit to the HADS and PSS-10 data of patients with RAS than the originally proposed model. These findings were consistent with recent validation studies of both scales in various medical diagnoses, 19,20 Several studies have found that patients with RAS had higher level of anxiety, 21,22 depression, 23 distress, 24 and psychological stress 25 when compared to healthy individuals, while some studies did not find the difference between two groups. 4,26 The prevalence of anxiety symptoms in the present RAS cohort was higher than that reported in a previous study of Croatian patients (42.5% vs 24.47%), whereas the figures for depressive symptoms were much lower (18.3% vs 47.06%).…”

Section: Discussionsupporting

confidence: 91%

“…Several studies have found that patients with RAS had higher level of anxiety, depression, distress, and psychological stress when compared to healthy individuals, while some studies did not find the difference between two groups . The prevalence of anxiety symptoms in the present RAS cohort was higher than that reported in a previous study of Croatian patients (42.5% vs 24.47%), whereas the figures for depressive symptoms were much lower (18.3% vs 47.06%) .…”

Section: Discussioncontrasting

confidence: 88%

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Validation of the HADS and PSS‐10 and a cross‐sectional study of psychological status in patients with recurrent aphthous stomatitis

Wiriyakijja

Porter

Fedele

et al. 2020

J Oral Pathology Medicine

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Objectives To validate the Hospital Anxiety and Depression Scale (HADS) and the 10‐item Perceived Stress Scale (PSS‐10) for use in clinical studies of recurrent aphthous stomatitis (RAS) and to provide cross‐sectional assessment of anxiety, depressive, and distress symptoms and perceived stress in patients with RAS. Methods The validity and reliability of the HADS and PSS‐10 were evaluated in 120 individuals with RAS through confirmatory factor analysis and calculation of Cronbach's alpha and omega coefficients. The prevalence of comorbid anxiety, depression, distress, and moderate‐to‐high perceived stress, and their association with demographics and clinical factors were assessed through cutoff scores of the HADS and PSS‐10 and bivariate analyses, respectively. Results A bi‐factor model, with all items loading onto general factor with two group factors, provides the best fit to the HADS and PSS‐10 data of this RAS cohort. While omega values suggested adequate reliability of total score of both scales, relatively low ranges of coefficient omega hierarchical limit utility of their subscale scores. The prevalence of anxiety, depression, distress, and moderate‐to‐high perceived stress was 42.5%, 18.33%, 28.33%, and 71.67%, respectively. Ethnicity, alcohol consumption, disease comorbidities, clinical type of RAS, ulcer size, pain, and RAS disease activity were found to be associated with negative psychological symptoms. Conclusion The HADS and PSS‐10 are valid and reliable as general scales of psychological distress and stress in patients with RAS. Significant mental burden among RAS patients makes the use of these validated instruments a sensible and prudent practice for psychological assessment of this patient group.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 88%

Validation of the HADS and PSS‐10 and a cross‐sectional study of psychological status in patients with recurrent aphthous stomatitis

Wiriyakijja

Porter

Fedele

et al. 2020

J Oral Pathology Medicine

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“…In this study, more than half of the respondents were anxious, 58.2%. This nding is consistent with papers published locally and abroad [17][18][19][20][21][22][23][24] . The highest rates of anxiety disorder among patients with RAS was reported by Ajmal et.al.…”

Section: Anxiety Associated With Rassupporting

confidence: 92%

Prevalence of Psychosomatic Disorders Among Dental Students with Recurrent Aphthous Stomatitis. A Cross-Sectional Study.

Hazzaa¹

2020

Preprint

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Aims To determine the prevalence of psychosomatic disorders among dental students with recurrent aphthous stomatitis. MethodA cross-sectional study was performed on 184 dental students with recurrent aphthous stomatitis (RAS). A p-value cut off point of 0.05 at 95% confident interval (CI) was used to determine statistical significance. Descriptive and inferential statistics were conducted where frequency and proportion were used, to present all categorical variables. Depression, Anxiety, Stress Scale questionnaires were used to assess the depression, anxiety, and stress of RAS dental students. The analysis assessed the relationship between RAS among socio-demographic characteristics of depression, anxiety, and stress by using a chi-square test.ResultsThe prevalence of depression was dominant among dental students at 62.5%. More than half of the respondents (58.2%) were anxious, whereas the prevalence of stress was lower i.e. 40.2%. There was no significant relationship found between depression and RAS (p>0.05).ConclusionAge group in years and number of ulcers in each occurrence were statistically associated for anxiety and stress, and gender was also significant to anxiety. There was no significant relationship found between depression and RAS.

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“…A more recent study showed that stressful life events were significantly associated with the onset of RAS episodes but not with the duration of the episodes [25]. Stress in RAS patients can elevate serum cortisol levels [26].…”

Section: Discussionmentioning

confidence: 99%

Serum Level of IL-6, Reactive Oxygen Species and Cortisol in Patients with Recurrent Aphthous Stomatitis related Imbalance Nutrition Intake and Atopy

Nur’aeny

Gurnida

Suwarsa

et al. 2020

J. Math. Fund. Sci.

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One of the most common oral ulcerations is recurrent aphthous stomatitis (RAS), affecting approximately 20% of the general population worldwide. The etiology of RAS is still unclear but it is considered to be multifactorial, including imbalanced nutrition intake and allergic conditions such as atopy. The purpose of this study was to investigate the differences and correlation between the serum level of IL-6, reactive oxygen species (ROS), and cortisol in RAS patients. Our study was cross-sectional and used a consecutive sampling method. There were significant differences of IL-6 and ROS levels in all groups (p = 0.000, p = 0.049 respectively) and a significant correlation between cortisol and ROS in the RAS group without atopy (r = -0.985, p = 0.015). Serum IL-6 and ROS measurement may be used for detecting RAS caused by malnutrition or atopy but not cortisol for patients without psychological stress detected. This is consistent with the results of a very strong correlation with a negative value between cortisol and ROS in RAS without atopy.

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Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis

Cited by 9 publications

References 24 publications

Validation of the HADS and PSS‐10 and a cross‐sectional study of psychological status in patients with recurrent aphthous stomatitis

Validation of the HADS and PSS‐10 and a cross‐sectional study of psychological status in patients with recurrent aphthous stomatitis

Prevalence of Psychosomatic Disorders Among Dental Students with Recurrent Aphthous Stomatitis. A Cross-Sectional Study.

Serum Level of IL-6, Reactive Oxygen Species and Cortisol in Patients with Recurrent Aphthous Stomatitis related Imbalance Nutrition Intake and Atopy

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