Association Between Adiponectin Production in Coronary Circulation and Future Cardiovascular Events in Patients With Coronary Artery Disease

Abstract

SummaryAdiponectin has antiatherosclerotic properties and is also produced in the local coronary circulation. We previously reported that signifi cantly less adiponectin was produced in the coronary circulation of patients with than without coronary artery disease (CAD). The goal of this study was to determine whether adiponectin production in the coronary circulation could predict future cardiovascular events in patients with CAD.Forty-eight CAD patients whose left anterior descending coronary arteries required percutaneous coronary intervention (PCI) were enrolled. The amount of adiponectin production in the coronary circulation was defi ned as the plasma adiponectin level at the great cardiac vein minus that at the orifi ce of the left coronary artery. All patients were divided by adiponectin production level in the coronary circulation into the adiponectin-positive production group (> 0 µg/ mL) and adiponectin-negative production group (≤ 0 µg/mL). Median follow-up period was 66 months (maximum, 108 months). The primary endpoint was the combined occurrence of major adverse cardiovascular events (MACE), including rehospitalization due to unstable angina, heart failure, nonfatal myocardial infarction, revascularization with PCI or coronary artery bypass grafting, ischemic stroke, and cardiovascular death.Sixteen MACE occurred. The incidence of MACE was signifi cantly higher in the adiponectin-negative production group than in the adiponectin-positive production group (P = 0.02). In multivariate analysis, adiponectin-negative production was a predictor of MACE (P = 0.03). Kaplan-Meier analysis revealed that the MACE-free rate was signifi cantly lower in the adiponectin-negative production group than in the adiponectin-positive production group.Adiponectin production in the coronary circulation with CAD may be associated with MACE. (Int Heart J 2014; 55: 239-243)

Serum Bilirubin Correlates with Serum Adipokines in Normal Weight and Overweight Asymptomatic Adults

“…Many other studies described this correlation in patients with liver cell injury, e.g., cirrhosis and cholestasis ( 26 ). It is important to notice that both serum bilirubin ( 6 ) and serum adiponectin ( 5 , 27 ) have beneficial effects in a variety of CVD. Moreover, both show negative correlation with obesity and BMI ( 5 , 9 ).…”

Biomarkers for Heart Failure in Asia

“…In 145 patients, plasma BNP measured at 3 to 4 months post-MI independently predicted death (n 5 23) over 5-year follow-up, whereas univariate predictors including left ventricular ejection fraction and a previous history of HF did not. Kawagoe and colleagues 35 reported that transcardiac net uptake versus net production of adiponectin was associated with adverse events in coronary artery disease (CAD), including risk of subsequent HF. Chen and colleagues 36 contributed original information in their report on phospholipid transfer protein (PLTP), a modulator of lipoprotein metabolism and a participant in inflammatory processes and oxidative stress.…”

Westernization of lifestyle affects quantitative and qualitative changes in adiponectin

“…Circulating APN is considered to be a cardiometabolic marker associated with global cardiovascular risk [1]. Hypoadiponectinemia is closely associated with the risk for insulin resistance [2, 3], metabolic syndrome [4] and coronary artery disease [5, 6]. …”