Association analysis of the IL-1 gene cluster polymorphisms with aggressive and chronic periodontitis in the Algerian population

Boukortt, Kawther Nourelhouda; Saidi-Ouahrani, Nadjia; Boukerzaza, Boubaker; Ouhaibi-Djellouli, H.; Hachmaoui, Khalida; Benaissa, Fatima Zohra; Taleb, Leila; Drabla-Ouahrani, Hayet; Deba, Tahria; Ouledhamou, Sid Ahmed; Mehtar, Nadhera; Boudjema, Abdallah

doi:10.1016/j.archoralbio.2015.06.018

Cited by 28 publications

(27 citation statements)

References 46 publications

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“…This finding contradicts others studies carried out in Caucasian populations from Australia (18) and Algerian (11). …”

Section: Discussioncontrasting

confidence: 99%

Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings

Ac²,

Lf³

et al. 2016

Med Oral

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BackgroundPeriodontitis results from an inflammatory response caused by accumulative microorganisms in periodontal sites. Several factors are involved in pathogenesis of periodontitis, for example the -889 C/T polymorphism in interleukin-1A gene. This study aimed to evaluate the relationship between this polymorphism and risk of development of chronic periodontitis by a meta-analysis based in new published findings.Material and MethodsThereunto a review in literature was performed in the electronic biomedical and education databases (Cochrane Library, Google Scholar, MEDLINE and PubMed) to studies published before August 2, 2015, the abstracts were evaluated and the data extraction performed by two calibrated examiners. The calculations of the meta-analysis were obtained through statistical software Review Manager version 5.2 with calculation of Odds Ratio (OR), heterogeneity (I²) and Funnel plots with P <0.05.ResultsIn overall, twenty-one case/control studies were selected with 2,174 patients with chronic periodontitis and 1, 756 controls. The meta-analysis showed T allele was associated with chronic periodontitis (OR = 1.22, 95% CI: 1.09, 1.36, P = 0.0004) with decreased value to heterogeneity (I² = 15%, P = 0.28). TT genotype was associated to patients with chronic periodontitis (OR = 1.40, 95% CI: 1.07, 1.83, P = 0.01). No publication bias was found in this meta-analysis by asymmetry in Funnel plots.ConclusionsThis meta-analysis with 2,174 patients with chronic periodontitis and 1, 756 controls evidenced the -889 C/T polymorphism is associated to risk of development of chronic periodontitis with no significant value to heterogeneity to allelic evaluation. Key words:Alleles, odds ratio, periodontal disease, cytokines.

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“…This finding contradicts others studies carried out in Caucasian populations from Australia (18) and Algerian (11). …”

Section: Discussioncontrasting

confidence: 99%

Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings

Ac²,

Lf³

et al. 2016

Med Oral

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“…Several studies strengthen the hypothesis of an association between IL1A and Tb, with Bellamy et al, the first to show a possible association of IL1A with susceptibility to Tb. In addition, the IL1A −889 C/T has been linked to increased cytokine production and several other inflammatory pathologies . The association between IL1A and Tb has also been observed in animal models …”

Section: Discussionmentioning

confidence: 92%

“…The SNP IL1A −889C/T has also been associated with several inflammatory diseases, such as allergic rhinitis, sepsis, periodontitis, and chronic pain in sickle cell anemia . In addition, the presence of the T allele has been linked with increased IL‐1α production .…”

Section: Discussionmentioning

confidence: 99%

“…Second, the −889C/T (rs1800587) SNP is located in the 5′‐untranslated region (5′‐UTR) of the IL1A gene and plays an important role in the transcriptional regulation of the gene, leading to an increased serum protein level . This polymorphism was previously associated with periodontitis, sepsis, and allergic rhinitis . Finally, the 5′‐UTR −308G>A (rs1800629) SNP in TNF was shown to promote a higher TNF mRNA transcription and is associated with a variety of diseases such as systemic lupus erythematosus, asthma, cervical cancer, and silicosis in different populations …”

Section: Introductionmentioning

confidence: 99%

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Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Salum

Castro

Moreira

et al. 2019

American J Industrial Med

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Introduction: Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tuberculosis (Tb).The contribution of inflammatory cytokines to the risk of silicosis and Tb in different populations has previously been reported. Since genetic background might be related to susceptibility to silicosis and Tb, the study of polymorphisms within IL-1α, IL-1β, and tumor necrosis factor protein-coding genes may contribute to elucidating the genetic basis of these diseases.Methods: Single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction using restriction fragment length polymorphism or by Taqman methodology, in a sample of 102 silica-exposed patients from Brazil.Results: No significant associations were observed between the SNPs studied and the severity of silicosis. However, significant associations were found between Tb and the C allele (odds ratio [OR] = 1.93, 95% confidence interval [CI], 1.01-3.73) and the CC genotype (OR = 2.34, 95% CI, 1.04-5.31) of IL1A −899C>T. The IL1B +3954C>T polymorphism also showed an association with Tb (T allele dominant model OR = 2.38, 95% CI, 1.04-5.41). Conclusion:These preliminary results demonstrate that the IL1A and IL1B gene variations may contribute to some extent to susceptibility to Tb, but not silicosis.However, additional studies are still needed to confirm these results.

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“…For example, The IL1A/B/RN locus was studied by several groups. However, there were some conflicting results, such as the African‐American family study implicating the rs1800857 C allele in periodontitis, while the Boukortt et al study found an association of the T allele with disease risk in Algerians. Another example was regarding rs16944 in IL1B , where heterogeneity was also found: Guzman et al identified the G risk allele in African‐Americans only, while another group found evidence for the T allele, and Wu et al only found significance for this SNP in diplotype combinations (some of the SNPs were in linkage disequilibrium).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Genetic polymorphisms and periodontal disease in populations of African descent: A review

Gonçalves

Harris

Elmariah

et al. 2017

J of Periodontal Research

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Aggressive periodontitis is a rare but rapidly progressing form of periodontal disease that usually affects otherwise systemically healthy individuals, at a young age. It usually affects first molars and incisors, which are usually lost if treatment is not properly and early rendered. Although of low prevalence, it affects individuals of African descent at a higher prevalence, and usually multiple members within the same family. Several studies have been performed in the attempt to evaluate specific single nucleotide polymorphisms (SNPs) that could be associated with this disease. To the best of our knowledge, the present article provides the first review of the literature focusing on studies that evaluated SNPs in patients of African descent with aggressive periodontitis. Several SNPs have been evaluated in different genes according to their role in the pathogenesis of the disease, with positive and negative associations (such as IL1, FCGR3B, FPR1, LTF, CYBA, GLT6D1, TLR4) with both the localized and generalized forms of aggressive periodontitis. Given the complexity of periodontitis, the difficulty in gathering large cohorts diagnosed with this rare form of disease, and the fact that candidate gene studies may only determine part of the genetic risk of a disease, the search for specific SNPs associated with aggressive periodontitis seems to be a long one, most likely to result in the combination of multiple SNPs, in multiple genes.

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Association analysis of the IL-1 gene cluster polymorphisms with aggressive and chronic periodontitis in the Algerian population

Cited by 28 publications

References 46 publications

Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings

Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Genetic polymorphisms and periodontal disease in populations of African descent: A review

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