Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings

Abstract

BackgroundPeriodontitis results from an inflammatory response caused by accumulative microorganisms in periodontal sites. Several factors are involved in pathogenesis of periodontitis, for example the -889 C/T polymorphism in interleukin-1A gene. This study aimed to evaluate the relationship between this polymorphism and risk of development of chronic periodontitis by a meta-analysis based in new published findings.Material and MethodsThereunto a review in literature was performed in the electronic biomedical and education databases (Cochrane Library, Google Scholar, MEDLINE and PubMed) to studies published before August 2, 2015, the abstracts were evaluated and the data extraction performed by two calibrated examiners. The calculations of the meta-analysis were obtained through statistical software Review Manager version 5.2 with calculation of Odds Ratio (OR), heterogeneity (I²) and Funnel plots with P <0.05.ResultsIn overall, twenty-one case/control studies were selected with 2,174 patients with chronic periodontitis and 1, 756 controls. The meta-analysis showed T allele was associated with chronic periodontitis (OR = 1.22, 95% CI: 1.09, 1.36, P = 0.0004) with decreased value to heterogeneity (I² = 15%, P = 0.28). TT genotype was associated to patients with chronic periodontitis (OR = 1.40, 95% CI: 1.07, 1.83, P = 0.01). No publication bias was found in this meta-analysis by asymmetry in Funnel plots.ConclusionsThis meta-analysis with 2,174 patients with chronic periodontitis and 1, 756 controls evidenced the -889 C/T polymorphism is associated to risk of development of chronic periodontitis with no significant value to heterogeneity to allelic evaluation. Key words:Alleles, odds ratio, periodontal disease, cytokines.

Detection of association between periodontitis and polymorphisms of IL‐1β + 3954 and TNF‐α ‐863 in the Korean population after controlling for confounding risk factors

“…7,8 On the other hand, many studies have suggested that genetic polymorphisms including single nucleotide polymorphisms (SNPs) in IL-1 and TNF-α genes are associated with susceptibility to periodontitis or severity of periodontal disease. [9][10][11][12][13][14] Among the SNPs known to be associated with periodontitis, IL-1α + 4845, IL-1β + 3954, and TNF-α −863 have been extensively investigated, 11,[15][16][17][18] and several comprehensive meta-analyses reported that risk of periodontitis is significantly associated with SNPs of IL-1 (IL-1α + 4845 and IL-1β + 3954) 9,[19][20][21][22][23][24] or TNF-α −863 polymorphism. 10 However, the previous studies were examined mainly in Caucasians and several Asian populations including Chinese, Japanese, and Indians.…”

Two-Way Relationship Between Helicobacter Pylori Infection and Periodontitis: Results from A Systematic Review and Meta-Analysis

“…In the field of oral diseases, there is the periodontitis, characterized as an immune-inflammatory disease as response to the presence of microorganisms in periodontal sites [14]. The pathogenesis of periodontitis receives influence of several factors including the colonization of periodontal sites by gram-positive and gram-negative bacteria species oral hygiene and genetic variations [15][16][17][18][19]. Both periodontitis and H. pylori infection had considerable worldwide prevalence and are associated with systemic conditions [8,[20][21][22][23].…”

Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis

“…Gene-related studies have confirmed that chronic periodontitis and aggressive periodontitis may be two different diseases [12], and interleukin (IL) gene polymorphisms possibly play a pivotal role in the occurrence and progression of chronic periodontitis [13][14][15]. The genes in IL-1 family have allele polymorphisms which may be related to the susceptibility of chronic periodontitis, in which single nucleotide polymorphism (SNP) -889C/T (rs1800587) in IL-1A gene is researched extensively [16][17][18][19]. IL-1A (-889C/T) is an SNP located at the position -889 upstream of translation start, and its polymorphism has a potential functional importance through the regulation on the IL-1 protein production [20].…”

“…Until now, a lot of studies have investigated the association between IL-1A (-889C/T) polymorphism and chronic periodontitis, but the results are inconsistent [16-18, 21, 22]. A previous meta-analysis reported that IL-1A (-889C/T) polymorphism was related to the susceptibility of chronic periodontitis, but the included studies were miscellaneous and Hardy-Weinberg equilibrium (HWE) test was not carried out [19]. Herein, an updated meta-analysis was conducted based on the currently available evidence, with the purpose of further clarifying the association between IL-1A (-889C/T) polymorphism and chronic periodontitis.…”