Associação entre doença periodontal e aterosclerose subclínica: uma revisão sistemática

Batista, Rafaela das Mercês; Zandonade, Eliana; Roelke, Leonard Hermann; Emmerich, Adauto; Rosetti, Elizabeth Pimentel; Molina, María del Carmen Bisi; Neto, Edson Theodoro dos Santos

doi:10.1590/s1677-54492011000300008

Cited by 7 publications

(8 citation statements)

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“…Most disease correlations were found for periodontitis with T2DM (n = 46) (19–21,24,26,29,30,38,40) and periodontitis with CVD (n = 33) (23,27,28,31,34,36,37,39,41–44,47,48). This was followed by SRs indicating correlations of tooth loss with CVD (n = 6) (28), periodontitis with cerebrovascular disease (n = 4) (25,28,32,35), and dental caries with T2DM (n = 4) (26).…”

Section: Resultsmentioning

confidence: 99%

“…The included SRs varied in diverse aspects. Multiple primary studies, including randomized controlled trials (RCTs) (14,15), case-control studies (CCSs) (22,23), cross-sectional studies (22,23), cohort studies (22), clinical trials (25), observational studies (32), mixed-method studies (32), pilot studies (41), and population surveys (41) were examined. The primary studies differed by study population, from 303 participants in an RCT (37) to 1,025,340 subjects in a CCS (39).…”

Section: Resultsmentioning

confidence: 99%

“…Multiple studies reported on common risk factors that can have a progressive effect on dental and chronic systemic conditions. The most frequently mentioned were smoking (21,23,35,36,39,41,43,44,46–48,50), age (23,35,36,39,41,43,47), sex (35,36,39,41,43), and body mass index (BMI) or overweight (35,36,39,44,46).…”

Section: Resultsmentioning

confidence: 99%

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Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review

et al. 2019

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IntroductionStudies have investigated the relationships between chronic systemic and dental conditions, but it remains unclear how such knowledge can be used in clinical practice. In this article, we provide an overview of existing systematic reviews, identifying and evaluating the most frequently reported dental–chronic disease correlations and common risk factors.MethodsWe conducted a systematic review of existing systematic reviews (umbrella review) published between 1995 and 2017 and indexed in 4 databases. We focused on the 3 most prevalent dental conditions and 10 chronic systemic diseases with the highest burden of disease in Germany. Two independent reviewers assessed all articles for eligibility and methodologic quality using the AMSTAR criteria and extracted data from the included studies.ResultsOf the initially identified 1,249 systematic reviews, 32 were included for qualitative synthesis. The dental condition with most frequently observed correlations to chronic systemic diseases was periodontitis. The chronic systemic disease with the most frequently observed correlations with a dental condition was type 2 diabetes mellitus (T2DM). Most dental–chronic disease correlations were found between periodontitis and T2DM and periodontitis and cardiovascular disease. Frequently reported common risk factors were smoking, age, sex, and overweight. Using the AMSTAR criteria, 2 studies were assessed as low quality, 26 studies as moderate quality, and 4 studies as high quality.ConclusionThe quality of included systematic reviews was heterogeneous. The most frequently reported correlations were found for periodontitis with T2DM and for periodontitis with cardiovascular disease. However, the strength of evidence for these and other disease correlations is limited, and the evidence to assess the causality of these disease correlations remains unclear. Future research should focus on the causality of disease links in order to provide more decisive evidence with respect to the design of intersectoral care processes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review

et al. 2019

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“…[6][7][8] The inflammation process of PD may trigger systemic inflammation that could be involved in the progression of atherosclerosis and consequently in CVD outcomes such as myocardial infarction or stroke. 9 However, it is not totally clear what the causal pathway between PD and CVD risk is.…”

Section: Introductionmentioning

confidence: 99%

Relationship between periodontal disease and cardiovascular risk factors among young and middle-aged Brazilians. Cross-sectional study

et al. 2017

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CONTEXT AND OBJECTIVE: It has been suggested in the literature that periodontal disease (PD) is associated with cardiovascular risk. The objective of this study was to appraise the relationship between periodontal disease (gingivitis and periodontitis) and traditional cardiovascular risk factors (obesity, hypertension, dyslipidemia, diabetes and metabolic syndrome) among young and middle-aged adults attended at a health promotion and check-up center in the city of São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study at the Health Promotion and Check-up Center of Hospital Sírio-Libanês, São Paulo, Brazil. METHODS:We consecutively evaluated 539 subjects without prior cardiovascular disease who were seen within a health promotion program that included cardiovascular and dental evaluation between February and November 2012. Odds ratios (OR) with respective 95% confidence intervals (95% CI) for the association between PD and cardiovascular risk factors were ascertained through multinomial logistic regression. RESULTS: In this sample of mean age 45 years (standard deviation, SD ± 8.8), which was 82% male, we found PD in 63.2% (gingivitis 50.6% and periodontitis 12.6%). Individuals with PD were older, more obese (without PD 15.2%; versus gingivitis 22.1% and periodontitis 32.4%) and more diabetic (without PD 5.1%; versus gingivitis 4.8% and periodontitis 13.2%), compared with those without PD. Among all cardiovascular risk factors evaluated, obesity was associated with periodontitis (multivariate OR, 2.36; 95% CI, 1.23-4.52). However, after additional adjustment for oral hygiene, this finding was no longer significant (multivariate OR, 1.63; 95% CI, 0.79-3.37). CONCLUSIONS:We did not find any significant associations between cardiovascular risk factors and periodontal disease in this sample. RESUMO CONTEXTO E OBJETIVO:A literatura sugere que doença periodontal (DP) está associada ao risco cardiovascular. O objetivo deste estudo foi avaliar a relação entre doença periodontal (gengivite e periodontite) e fatores de risco cardiovasculares tradicionais (obesidade, hipertensão, dislipidemia, diabetes e síndrome metabólica) em adultos jovens e de meia-idade atendidos em um centro de promoção da saúde e check-up na cidade de São Paulo, Brasil. TIPO DE ESTUDO E LOCAL: Estudo transversal no Centro de Promoção de Saúde e check-up do HospitalSírio-Libanês, São Paulo, Brasil. MÉTODOS: Avaliamos consecutivamente 539 indivíduos sem doença cardiovascular diagnosticada, observados em um programa de promoção da saúde que incluiu avaliação cardiovascular e odontológica de fevereiro a novembro de 2012. Razões de chances (RC) com respectivos intervalos de confiança de 95% (IC 95%) para a associação entre DP e fatores de risco cardiovascular foram calculadas por regressão logística multinomial. RESULTADOS: Nesta amostra de pessoas com idade média de 45 anos (desvio padrão, DP ± 8,8), 82% de homens, encontramos 63,2% de casos de DP (50,6% de gengivite e periodontite 12,6%). Indivíduos com DP eram mais velhos, mais obesos (se...

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“…Indeed, there is a bidirectional relationship between psoriasis and periodontitis, where systemic inflammation produced by psoriasis may increase the severity of periodontitis, and this focus of infection acts as a triggering factor for psoriasis 49. Furthermore, periodontal disease causes vascular endothelial infection, local increase of white cells, tissue growth factors and endotoxins, favoring atherosclerosis and erectile dysfunction 50…”

Section: Introductionmentioning

confidence: 99%

Psoriasis and sexual dysfunction: links, risks, and management challenges

Duarte

Calmon²,

Radel³

et al. 2018

PTT

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According to the WHO, sexual health is not merely the absence of disease. Sexual dysfunction may be present in 40.8% of psoriasis patients, furthermore, 68% prevalence was found in Brazilian women with psoriasis. The moderate prevalence of psoriatic lesions in the genital area (35%–42%) does not explain the alarming prevalence of sexual dysfunction. Other factors, such as anxiety, depression, and also psoriasis treatment may contribute to its development. Likewise, atherosclerosis of the pelvic vasculature is involved in the pathogenesis of erectile dysfunction. Risk factors for erectile dysfunction tend to be confused with the comorbidities seen in psoriasis patients. We also highlight that it may serve as a marker of cardiovascular risk.

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Associação entre doença periodontal e aterosclerose subclínica: uma revisão sistemática

Cited by 7 publications

References 71 publications

Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review

Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review

Relationship between periodontal disease and cardiovascular risk factors among young and middle-aged Brazilians. Cross-sectional study

Psoriasis and sexual dysfunction: links, risks, and management challenges

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