Psoriasis and sexual dysfunction: links, risks, and management challenges

Duarte, Gleison Vieira; Calmon, Humberto; Radel, Gabriela; Oliveira, Maria de Fátima

doi:10.2147/ptt.s159916

Cited by 23 publications

(36 citation statements)

References 55 publications

(61 reference statements)

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“…The side effects of the drugs used for the disease and thought of skin findings have a negative impact on the partner, since they cause sexual reluctance and loss of confidence. Besides, common etiological factors such as atherosclerosis have been suggested to play a role on the increased frequency of ED (27).…”

Section: Resultsmentioning

confidence: 99%

Onychomycosis and Erectile Dysfunction. Does Common Etiology Cause Togetherness?

Baran

Aykaç

Kaya

et al. 2021

Batı Karadeniz Tıp Dergisi

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Aim:We tried to determine the frequency of co-occurrence of erectile dysfunction (ED) and Onychomycosis (OM). Material and Methods:The sociodemographic form and IIEF-5 form were filled by the male patients who were admitted to the Urology Polyclinic of Karabük University Medical Faculty with the complaints of ED between April 2019 -April 2020. The patients with ED were included in the study. All the male patients were divided into three groups as mild, moderate and severe according to ED severity. The dermatologist (H.A) examined the presence of OM by taking samples from the toenails of the male patients.Results: Looking at the IIEF-5 scores of 95 patients accepted to the study, it was found that 22 (23.1%) had mild, 20 (21%) moderate and 53 (55.9%) severe ED. Smoking history was higher in the severe ED group (p <0.001). It was found that a total of 32 (33.7%) patients had OM. However, there was no relationship between the severity of ED and the presence of OM (p> 0.114). Conclusion:Erectile dysfunction and OM disease can often be seen together. However, no relationship was found with the severity of ED.

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Section: Resultsmentioning

confidence: 99%

Onychomycosis and Erectile Dysfunction. Does Common Etiology Cause Togetherness?

Baran

Aykaç

Kaya

et al. 2021

Batı Karadeniz Tıp Dergisi

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“…Psoriasis in the genital and intertriginous areas does not always present with the common characteristics of a typical plaque psoriasis. Studies have shown that patients with genital psoriasis reported lower overall quality of life compared with psoriatic patients without genital involvement [ 2 , 3 ]. Patients experience significantly higher internalized stigma and impairments in physical activities as well as relationships with others.…”

Section: Discussionmentioning

confidence: 99%

“…Psoriatic lesions in these areas may be smooth and non-scaly, and the genital localization can result in debilitating emotional and physical distress as well as sexual dysfunctions. Genital psoriasis is associated with poor quality of life and significant amount of stress, even though it affects only a small portion of body surface area (BSA) [ 2 , 3 ]. While it is more common in men, the severity of symptoms is higher in women [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Genital and Inverse/Intertriginous Psoriasis: An Updated Review of Therapies and Recommendations for Practical Management

Hong

Mosca

Hadeler

et al. 2021

Dermatol Ther (Heidelb)

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Genital and inverse psoriasis can develop in more than one-third of patients who have psoriasis. Psoriatic plaques in the genital and intertriginous skin are challenging to treat because the skin is thin and often occluded, making it more sensitive to certain therapies. Traditional guidelines indicate topical therapies, such as corticosteroids, topical calcineurin inhibitors (TCI), and vitamin D analogs as firstline recommendation in treating genital and inverse psoriasis. There have been developments in the treatment of genital and inverse psoriasis using systemic therapies, including IL-17 inhibitors and PDE-4 inhibitors.

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“…It is evident that the longer the duration of untreated psoriasis, the higher the chances of developing infertility [33]. However, it is not clear whether the treatment of psoriasis can improve or worsen sexual dysfunction, as the treatment for psoriasis is linked to the development of sexual dysfunction in both males and females [34]. The average time within which a patient seeks psoriasis treatment is around five to six months [35], and beyond that, permanent and irreversible infertility may develop [36].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of sex hormone profiles and seminal fluid analysis in psoriatic patients and their correlation with psoriasis severity

Alzubi¹,

Seetan²,

Jarrar³

et al. 2021

J. Mens. Health

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Background and objective: Psoriasis is a chronic inﬂammatory skin condition characterized by thick silvery plaques, commonly involving the elbow, knees, lower back, and scalp. Psoriasis also affects the reproductive systems of patients. Males with untreated psoriasis are at risk of impaired fertility due to chronic systemic inﬂammation, which might affect the hormonal proﬁle and sexual accessory glands. In females, having psoriasis does not affect the chances of getting pregnant. This study aims to assess the effect of psoriasis, as a chronic inﬂammatory condition, on sex hormone proﬁles and seminal ﬂuid parameters. Methods: 87 male patients aged 18−50 with psoriasis who fulﬁlled the inclusion criteria were included in the study and matched with healthy controls. Demographic and clinical data, including age, severity, duration, and body mass index (BMI) were recorded. All patients underwent a complete physical exam, including a skin and andrological exam, in addition to ultrasound scrotum and seminal ﬂuid analysis. Blood sample tests were conducted for a complete hormonal proﬁle, including luteinizing hormone (LH), follicular stimulating hormone (FSH), testosterone, and estradiol. Results: The mean age of the case group was 39.5 ± 5.6 years, and the mean BMI was 24.0 ± 2.2. The mean duration of psoriasis was 6.5 ± 3.5 years. The mean levels of testosterone and LH of cases were lower than those of controls, whereas FSH and estradiol were abnormally higher among case groups. Sperm concentration, normal sperm motility, and normal sperm morphology were also found to be lower than in the case group. Age, psoriasis area, and severity index (PASI) scores were signiﬁcant predictors of sperm concentration (P = 0.000). The BMI was negatively correlated with sperm concentration (−0.249, P = 0.01), motility (−0.198, P = 0.05), and morphology (−0.205, P = 0.05). A negative correlation was found between the PASI score and sperm concentration (−0.519, P = 0.01). Conclusion: The evaluation of seminal ﬂuid analysis and hormone proﬁles among psoriasis patients showed marked variability. However, it was evident that the levels of sex hormones and seminal parameters were lower among patients with psoriasis than the healthy controls; this may indicate the possibility of developing sexual dysfunction and infertility among patients with untreated psoriasis. The level of estradiol was found to be abnormally high among psoriasis cases, which may account for a possible compensatory mechanism in ongoing sexual dysfunction among psoriasis patients.

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Psoriasis and sexual dysfunction: links, risks, and management challenges

Cited by 23 publications

References 55 publications

Onychomycosis and Erectile Dysfunction. Does Common Etiology Cause Togetherness?

Onychomycosis and Erectile Dysfunction. Does Common Etiology Cause Togetherness?

Genital and Inverse/Intertriginous Psoriasis: An Updated Review of Therapies and Recommendations for Practical Management

Evaluation of sex hormone profiles and seminal fluid analysis in psoriatic patients and their correlation with psoriasis severity

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