Assisted 3D printing of microneedle patches for minimally invasive glucose control in diabetes

Wu, Mingxin; Zhang, Yujie; Huang, He; Li, Jingwen; Liu, Haiyang; Guo, Zhaoyang; Xue, Longjian; Liu, Sheng; Lei, Yifeng

doi:10.1016/j.msec.2020.111299

Cited by 101 publications

(49 citation statements)

References 57 publications

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“…262 Wu et al used extrusion-based 3D printing and post stretching to fabricate a microneedle patch system for minimally invasive and glucose-responsive insulin delivery for diabetes treatment. 263 submit your manuscript | www.dovepress.com…”

Section: D-printedmentioning

confidence: 99%

“… 3D printed scaffolds have shown an excellent antibacterial effect [ 262 ] Microneedle patches. Regulated the blood glucose levels of diabetic mice in normoglycemic ranges for up to 40 h [ 263 ] Radially or vertically aligned nanofibers in combination with BMSCs. Enhancing the formation of granulation tissue, promoting angiogenesis, and facilitating collagen deposition.…”

Section: Technologymentioning

confidence: 99%

See 1 more Smart Citation

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

116

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Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments of nanoparticles/hydrogels and nanotechnology used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. These nanoparticles/hydrogels promote diabetic wound healing by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) and nonbioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favored by researchers. In addition, nanoparticles/hydrogels can be combined with some technology (including PTT, LBL self-assembly technique and 3D-printing technology) to treat diabetic wound repair. By reviewing the recent literatures, we also proposed new strategies for improving multifunctional treatment of diabetic wounds in the future.

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Section: D-printedmentioning

confidence: 99%

Section: Technologymentioning

confidence: 99%

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

116

View full text Add to dashboard Cite

show abstract

“…It further offers new potentials in medicine by aiding in the preparation of personalized and controlled release therapeutic systems with fabrication of compliant procedures for patients. [9][10][11][12][13] 3D printing technology enables the production of scaffolds that can incorporate nucleic acids, growth factors, stem cells, etc. and offers a platform for desired (localized, safe and sustained) release of such molecules in the body.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression

Shende

Trivedi

2021

Stem Cell Rev and Rep

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Layer-by-layer deposition of cells, tissues and similar molecules provided by additive manufacturing techniques such as 3D bioprinting offers safe, biocompatible, effective and inert methods for the production of biological structures and biomimetic scaffolds. 3D bioprinting assisted through computer programmes and software develops mutli-modal nano-or micro-particulate systems such as biosensors, dosage forms or delivery systems and other biological scaffolds like pharmaceutical implants, prosthetics, etc. This review article focuses on the implementation of 3D bioprinting techniques in the gene expression, in gene editing or therapy and in delivery of genes. The applications of 3D printing are extensive and include gene therapy, modulation and expression in cancers, tissue engineering, osteogenesis, skin and vascular regeneration. Inclusion of nanotechnology with genomic bioprinting parameters such as gene conjugated or gene encapsulated 3D printed nanostructures may offer new avenues in the future for efficient and controlled treatment and help in overcoming the limitations faced in conventional methods. Moreover, expansion of the benefits from such techniques is advantageous in real-time delivery or in-situ production of nucleic acids into the host cells.

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“…AM, commonly known as three-dimensional (3D) printing, rapid prototyping, or solid free form fabrication (SFF), represents a family of techniques launched in the 1980s that revolutionized not only the pharmaceutical industry [ 17 , 19 ] but also the majority of industrial and scientific fields such as automotive [ 20 ], aerospace [ 21 ], construction [ 22 ], and consumer electronics industries [ 23 ]. The term “3D printing” was defined by the International Standard Organization (ISO) as “ the fabrication of objects through the deposition of a material using a print head, nozzle, or another printer technology ” [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…More than 10 different AM technologies have been proposed since Chuck Hull’s first development and commercialization of stereolithography apparatus (SLA) back in 1986. They include material extrusion, vat photopolymerization, material and binder jetting, powder bed fusion (PBF), directed energy deposition, and sheet lamination [ 26 , 27 , 28 ], which have been used for the precise manufacture of various drug dosage forms for oral [ 29 , 30 , 31 ], transdermal [ 26 , 27 , 32 , 33 ], vaginal [ 34 ], and subcutaneous [ 35 ] applications, as well as implants and prosthetics, whose high tunability and complexity are unattainable by conventional techniques [ 7 , 19 ]. More recently, the wide range of 3D printing technologies has opened an interesting new field of research to produce MNs, which will be explained in the next sections.…”

Section: Introductionmentioning

confidence: 99%

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined.

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Assisted 3D printing of microneedle patches for minimally invasive glucose control in diabetes

Cited by 101 publications

References 57 publications

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

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