Assessments of Immunological Activity of Achillea Millefolium Methanolic Extract on Albino Male Mice

Al-Ezzy, Ruqaya M.; Anee, Rafal S. A. Al; Ibrahim, Niran A.

doi:10.17265/2328-2150/2018.06.002

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Miers (family: Menispermaceae) ( Mathew and Kuttan, 1999 ), Withania somnifera (L.) Dunal (family: Solanaceae) ( Davis and Kuttan, 2000 ), Curcuma longa L. (family: Zingiberaceae) ( Kim et al, 2014 ), Ocimum sanctum L. (family: Lamiaceae) ( Mondal et al, 2011 ), Azadirachta indica A. Juss. (family: Meliaceae) ( van der Nat et al, 1987 ), Achilla millefolium L. (family: Asteraceae) ( Mohammed Al-Ezzy et al, 2018 ), and many more are the reported herbs exhibiting excellent immunomodulatory activity. Based on our preliminary study, we focused only on the first four plants, namely, P. emblica , P. nigrum , T. cordifolia , and W. somnifera .…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Profiling and Immunomodulatory Activity of a Polyherbal Combination in Cyclophosphamide-Induced Immunosuppressed Mice

et al. 2022

View full text Add to dashboard Cite

The study was aimed to develop a characterized polyherbal combination as an immunomodulator containing Phyllanthus emblica L., Piper nigrum L., Withania somnifera (L.) Dunal, and Tinospora cordifolia (Willd.) Miers. Through response surface methodology (RSM), the ratio of aqueous extracts of four plant materials was optimized and comprised 49.76% of P. emblica, 1.35% of P. nigrum, 5.41% of W. somnifera, and 43.43% of T. cordifolia for optimum immunomodulatory activity. The optimized combination showed antioxidant potential and contains more than 180 metabolites, out of which gallic acid, quercetin, ellagic acid, caffeic acid, kaempferitrin, and p-coumaric acid are some common and significant metabolites found in plant extracts and in polyherbal combination. Treatment with the polyherbal combination of different doses in cyclophosphamide-induced immunosuppressed mice significantly (p < 0.01) enhanced the subsets of immune cells such as natural killer (NK) cells (60%), B cells (18%), CD4 cells (14%), and CD8 cells (7%). The characterized polyherbal combination exhibited potent immunomodulatory activity, which can be further explored clinically for its therapeutic applicability.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolomic Profiling and Immunomodulatory Activity of a Polyherbal Combination in Cyclophosphamide-Induced Immunosuppressed Mice

et al. 2022

View full text Add to dashboard Cite

show abstract

Biochemical, Enzymatic, and Immunological Study on Antimutagenic Achillea millefolium Methanolic Extract in vivo

Hussein¹,

Al-Ezzy²,

Abdallah³

2019

JPP

View full text Add to dashboard Cite

Traditionally medicinal plants are used for its potential chemotherapeutic action and for safety upon the continued use of these plants. Achillea millefolium (AM) is an ancient herb which is used to treat wounds, headaches, disorder in gastrointestinal and hepatobiliary, pain, and inflammation. This study was aimed to investigate the biochemical parameter of antimutagenic methanolic extract for AM in vivo. Plant extract together with MTX decreased the damage caused by the drug on the concentrations of total cholesterol and triglycerides (160.3±2.26 and 108.7±2.71), significant increase in total protein concentration (8.51±0.17, 9.46±0.19 and 10.8±2.71 g\dL) for 100 and 200 mg\kg was observed. Also plant extracts counteract the damage caused by drug through the reduction for both creatinin and albumin concentrations to 1.57±0.03 mg\dL and 4.56±0.09 g\dL, respectively. On enzymatic level, the results of interactions indicated the ability of plant to modulating harmful effects of the drug (57.1±1.3, 130±3.1 and 111.1±2.1 U\L) for GOT, GPT and ALP, respectively. On the other hand, the plant possesses the ability to enhance the concentrations of all immunoglobulin (IgM, IgA and IgG) in the two doses tested. Therefore, the results of this study indicate the antimutagenic potential of AM extract and encouraging its consumption with MTX as one of the promising therapies.

show abstract

Protective activity of Ruta chalepensis methanolic extract against nephrotoxicity and testicular damage induced by Carbon tetrachloride on albino male mice

Yahya

Okhti

Al-Ezzy

et al. 2021

RJPT

View full text Add to dashboard Cite

Herbal medicinal products can contain whole or partially prepared plant components from plant leaves, bark, stems, flowers and seeds.They are administered orally, inhaled or directly applied in the skin. Ruta chalepensis is a wild herb of the Mediterranean region used by many countries in herbal medicine. The existence of bioactive molecules responsible for their pharmacological properties has been shown by phytochemical screening. Results of kidney protective activity of plant. Showed that: for total cholesterol, the effect was dose dependant (50 and 100 mg\kg) in which the plant decreased it in compared to positive and negative groups (162.1±1.83 and 154.6±1.11 mg\dl) compared to (202.1±1.13 and 167.5±2.96 mg\dl) respectively. For total protein, creatinin and albumin the plant also had the ability to keep it near control groups compared to CCL4group.While the results of interaction groups indicated the ability of plant to provide protection against CCL4 damage. the plant possessed the ability to keep testosterone, progesterone and estrogen hormones level near normal in compared to CCL4 treated group (2.96±0.03, 1.93±0.01 and 3.63±0.04 ng\dl); (11.51±4.12, 9.85±2.18 and 11.78±3.42 ng\ml); (29.07±7.21, 30.11±9.11 and 30.67±8.98 ng\ml) for 50,100 mg\kg and negative control respectively. While for interaction group the results showed the ability of plant to counteract the damaged caused by CCL4 (1.67±0.01, 2.54±0.02); (10.42±2.21, 13.65±4.37); (39.74±10.13, 35.45±9.91) for testosterone, progesterone and estrogen hormones in Ruta chalepensis +CCL4 at dose (50 +0.02%) and (100+0.02%) respectively. All results of histo-architecture for kidney and testis showed the ability of plant to counteract any necrosis and abnormality caused by CCL4.

show abstract

Assessments of Immunological Activity of Achillea Millefolium Methanolic Extract on Albino Male Mice

Cited by 3 publications

References 13 publications

Metabolomic Profiling and Immunomodulatory Activity of a Polyherbal Combination in Cyclophosphamide-Induced Immunosuppressed Mice

Metabolomic Profiling and Immunomodulatory Activity of a Polyherbal Combination in Cyclophosphamide-Induced Immunosuppressed Mice

Biochemical, Enzymatic, and Immunological Study on Antimutagenic Achillea millefolium Methanolic Extract in vivo

Protective activity of Ruta chalepensis methanolic extract against nephrotoxicity and testicular damage induced by Carbon tetrachloride on albino male mice

Contact Info

Product

Resources

About