Assessment of vitamin K deficiency in CF—how much sophistication is useful?

Mosler, Katharina; Kries, Rüdiger von; Vermeer, Cees; Saupe, Jörg; Schmitz, Thomas; Schuster, Antje

doi:10.1016/s1569-1993(03)00025-0

Cited by 32 publications

(21 citation statements)

References 18 publications

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“…In EPI, lipase deficiency prevents breakdown of dietary triglycerides into monoglycerides and fatty acids, causing an inadequate solubilization and absorption of fat-soluble vitamins, including vitamin K. This produces vitamin K deficiency as described in humans (Edwards & Russel, 1987;Dutta et al ., 1982;Sinaasappel et al ., 2002;Mosler et al ., 2003). In dogs with EPI, malabsorption of fat-soluble vitamins may be suspected but the importance of vitamin A, vitamin D, vitamin E and vitamin K deficiency in dogs has not been reported (Westermarck et al ., 2005).…”

Section: Discussionmentioning

confidence: 99%

Exocrine pancreatic insufficiency in pigeons

et al. 2006

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Exocrine pancreatic insufficiency (EPI) is a well-studied syndrome in domestic animals. EPI occurs when severe progressive loss of tubulo-acinar tissue from atrophy or inflammatory destruction results in insufficient secretion of digestive enzymes and clinical signs of malabsorption. However, the literature on EPI in birds is limited. The syndrome has been previously described in several cases where the diagnosis was based on clinical signs due to malabsorption-like light-coloured voluminous faeces, voracious appetite, coprophagia and weight loss, and on the response to treatment with pancreatic enzyme formulas. To enable a more scientific approach to the diagnosis of pancreatic functional disorders in pigeons, reference values of plasma amylase (382 to 556 IU/l), lipase (0 to 5 IU/l), and faecal activities of amylase (13 to 16 IU/l) and trypsin (11 to 14 IU/l) were determined in 24 adult pigeons. A case of EPI in a racing pigeon (Columba livia domestica) is reported, based on the clinical signs and the measurement of faecal amylase and trypsin activity.

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Section: Discussionmentioning

confidence: 99%

Exocrine pancreatic insufficiency in pigeons

et al. 2006

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“…14 Mosler et al, demonstrated normal PIVKA-II concentrations only in two cases among 15 CF subjects with liver disease who were receiving oral ursodeoxycholic acid due to high GGT activity. 13 Rashid et al, and Wilson et al, documented pathological PIVKA-II concentrations in all CF patients with liver disease (n= 8 and n= 6, respectively). 31,34 Recently, we found evidence that vitamin K deficiency is more frequent in CF patients with liver cirrhosis than in those without.…”

Section: Clinical Biochemical and Functional Parameters In Cf Patimentioning

confidence: 93%

“…11,12 Vitamin K deficiency predisposes CF patients to easy bruising and bleeding (especially among infants), defective bone mineralization and osteoporosis. [13][14][15] R o u t i n e v i t a m i n K s u p p l e m e n t a t i o n in CF patients is recommended in many countries.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vitamin K deficiency and associated factors in non-supplemented cystic fibrosis patients

Krzyżanowska

Drzymała-Czyż

Rohovyk

et al. 2018

Arch Argent Pediatr

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Introduction. Vitamin K deficiency is highly prevalent in cystic fibrosis (CF) patients despite supplementation. Moreover, no reliable risk factors for its occurrence are known. The aim was to assess the prevalence of vitamin K deficiency and associated factors in non-supplemented CF patients. Methods. Prothrombin concentration induced by vitamin K absence (PIVKA-II) and the undercarboxylated osteocalcin percentage (u-OC) were determined. In all patients clinical status was assessed and its relation to vitamin K deficiency determined. The following tests were used for statistical analysis: Mann-Whitney test, ANOVA test or the Kruskal Wallis test, the chi-squared test or the Fisher-Freeman-Halton test, and multiple linear and multiple forward stepwise logistic regression analysis. Results. The study group comprised 79 CF patients aged 0.4-25.3 years. PIVKA-II and u-OC were abnormal in 56 (70.9%) and 45 (57.0%) patients. Patients with elevated PIVKA-II were significantly older (p= 0.0184) and had lower Z-score values for body weight (p= 0.0297) than those with normal concentrations. Patients with normal or pathological u-OC percentage did not differ. Abnormal PIVKA-II and u-OC were reported more frequently in subjects with two severe CFTR mutations and with worse/poor nutritional status. Multiple linear and forward stepwise regression analyses did not reveal strong predictive factors of vitamin K deficiency. Conclusion. Vitamin K deficiency is highly prevalent in the natural course of cystic fibrosis. There are no reliable clinical determinants of its occurrence.

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“…14 Mosler y col. demostraron concentraciones normales de PIVKA-II solamente en dos de 15 sujetos con FQ con hepatopatía que recibían ácido ursodesoxicólico por vía oral debido a una actividad elevada de la GGT. 13 Rashid y col. y Wilson y col., documentaron concentraciones patológicas de PIVKA-II en todos los pacientes con FQ y hepatopatía (n= 8 y n= 6, respectivamente). 31,34 Recientemente, se halló evidencia de que la deficiencia de vitamina K era más frecuente en los pacientes con FQ y cirrosis hepática que en aquellos que no la tenían.…”

Section: Tabla 5 Análisis De Regresión Múltiple Escalonada Hacia Adeunclassified

“…11,12 La deficiencia de vitamina K predispone a los pacientes con FQ a desarrollar hematomas y hemorragia fácilmente (en especial, en los lactantes), mineralización ósea deficiente y osteoporosis. [13][14][15] En muchos países, se recomienda el aporte suplementario habitual de vitamina K en los pacientes con FQ.…”

Section: Introductionunclassified