Assessment of Tumor Associated Tissue Eosinophilia (TATE) in Oral Squamous Cell Carcinoma Using Carbol Chromotrope Stain

Peter, Celestina Dawn; Raju, Shashidara; Haragannavar, Vanishree C; Samuel, Pradeep; Sridhara, Sudheendra Udyavara; Gopalkrishna, Aparna H.; Poojary, Sheela; Nayak, Suhas R; A, Anu Sushanth

doi:10.4067/s0718-381x2015000100014

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…There was elevated TATE in stages III and IV, so increased eosinophilia was associated with T3 and T4, suggestive of increased eosinophil count with increased primary tumor size. Celestina Dawn Peter et al 32 have also reported an increase in eosinophil count with an increase in the tumor size. Oliveira et al 9 showed absent/mild eosinophils in early clinical stages, i.e., stages I and stage II while significantly higher eosinophilia was seen in stages III and IV, suggesting increased eosinophilia with increasing clinical stages.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of Tumor-associated Tissue Eosinophilia in Different Stages of Oral Squamous Cell Carcinoma using Special Stains: Anin vitroHistopathological Study

Vaibhav

Priya

Sonam

et al. 2018

The Journal of Contemporary Dental Practice

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Section: Discussionmentioning

confidence: 92%

Evaluation of Tumor-associated Tissue Eosinophilia in Different Stages of Oral Squamous Cell Carcinoma using Special Stains: Anin vitroHistopathological Study

Vaibhav

Priya

Sonam

et al. 2018

The Journal of Contemporary Dental Practice

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“…[12] In HNSCC, the presence of eosinophils in the stromal infiltrate ranges between 22% and 89%. [13] This stromal eosinophilic infiltrate in tumors is termed as tumor-associated tissue eosinophilia (TATE). TATE was first described by Prezewoski in 1896 in carcinoma of the uterine cervix as “eosinophilic stromal infiltration of a tumor not associated with tumor necrosis or ulceration.”[14] TATE is characterized by the presence of eosinophils as a component of peritumoral and intratumoral inflammatory infiltrate.…”

Section: Introductionmentioning

confidence: 99%

Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma

Deepthi

Kulkarni

Nandan

2019

J Oral Maxillofac Pathol

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Background: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the important hallmarks, the exact role of eosinophils remains unclear. Various studies on oral squamous cell carcinoma (OSCC) that focused on eosinophils reported both favorable and unfavorable prognosis in cancer tissue, because of which the exact function of eosinophils still remains uncertain. Aims and Objectives: The present study aims at identifying the role of TATE in OSCC and in malignant transformation of oral epithelial dysplasia (OED). Materials and Methods: The study includes 70 samples that divided into two groups, of which 50 histopathologically proven cases of different grades of OSCC and 20 cases of OED (oral leukoplakia). Congo red stain was used to stain the tissue sections. Each slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils. Results: Statistical analysis of values obtained was done using ANOVA, unpaired t -test and Mann–Whitney test. The results were statistically significant ( P < 0.05) with a mean total eosinophil count of 2.12 in OED and 4.31 in OSCC. Conclusion: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC.

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“…[5] These multifunctional, multifaceted leukocytes play a key role in health and disease, are also involved in the pathogenesis, inflammatory processes, infectious diseases, tissue injury, tumor immunity, and allergic reactions. [6] Infiltration of eosinophils in the tumor environment plays an important role in biological behavior of cancer such as carcinoma stromal interactions. Tumor-associated tissue eosinophilia (TATE) is characterized by the presence of eosinophils as a component of peritumoral and intratumoral inflammatory infiltrate.…”

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confidence: 99%

“…Hence, in this study, carbol chromotrope was used, with a benefit that it selectively and vividly stains eosinophils. [6] The aim of this study is to compare the tissue eosinophils in OSCC and normal tissue and to correlate the expression of TATE in different grades of OSCC.…”

mentioning

confidence: 99%

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

Shrestha

Narayan

Kumar

et al. 2020

JGOH

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Objectives: Squamous cell carcinoma of the oral cavity is the most common aggressive epithelial malignant neoplasm. Its biological behavior is influenced by the host immune cells, such as multifaceted eosinophils, associated with wound healing and tissue damage processes. Their presence within a variety of human cancers raises queries about their role. The infiltrations of tumor stroma by eosinophils are believed to play a significant role in progression of the carcinoma and could be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. Its role in cancer still remains unclear since in the literature, there are very few studies showing improved prognosis and few contradictory studies showing poor prognosis. This study was conducted with an aim to compare the tumor-associated tissue eosinophilia in oral squamous cell carcinoma (OSCC) and normal tissue and to correlate the expression in different grades of carcinoma using a special stain that targets eosinophils exclusively and vividly. Materials and Methods: The study includes 30 samples, six normal, and 24 histopathologically diagnosed with OSCC. 5 μ thick sections were made and stained using special stain and examined under high power (×40), ten consecutive microscopic fields were studied. The average numbers of eosinophils were statistically analyzed. Results: Eosinophil count for carcinoma was higher compared to normal mucosa, but the comparison in different grades of cancer did not show much difference. Conclusion: Since eosinophil count was higher in carcinoma, eosinophil infiltration in dysplastic cases should prompt thorough evaluation for invasiveness.

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Assessment of Tumor Associated Tissue Eosinophilia (TATE) in Oral Squamous Cell Carcinoma Using Carbol Chromotrope Stain

Cited by 7 publications

References 8 publications

Evaluation of Tumor-associated Tissue Eosinophilia in Different Stages of Oral Squamous Cell Carcinoma using Special Stains: Anin vitroHistopathological Study

Evaluation of Tumor-associated Tissue Eosinophilia in Different Stages of Oral Squamous Cell Carcinoma using Special Stains: Anin vitroHistopathological Study

Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

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