Tumor related tissue eosinophilia (TATE) is a known phenomenon but its role in prognostics and correlation with size of the primary tumor is still controversial. Using a stain, like Carbol chromotrope, that targets eosinophils exclusively and vividly, offers an advantage over haematoxylin and eosin, which was used in most of the studies. Forty-nine cases of oral squamous cell carcinoma, where the TNM staging has been recorded in their history, was taken and stained with Lendrum's carbol chromotrope. Significant difference in the eosinophil count with varying size of the tumor and a parallel increase in the number noted, with increase in size. There is a corresponding increase in the number of eosinophils infiltrating the tumor with increase in size of oral squamous cell carcinoma.
Background: Oral lichen planus is a T-cell-mediated chronic inflammatory disease affecting approximately 1% to 2% of the population, the etiology of which is currently unknown. The objectives of this study were to observe if senescence occurs in oral lichen planus, through the assessment of the immunohistochemical expression of a novel marker for senescence called Senescence marker protein-30 or regucalcin, and compare the expression to that in oral lichenoid reaction and non-specific inflammation. Subjects and Methods: The study material consisted of 30 cases of oral lichen planus, 15 cases of oral lichenoid reaction and 15 cases of non-specific inflammation. The number of positive cells in ten randomly selected high power fields were counted in the epithelium and the connective tissue separately and the mean was determined. Results: Mann–Whitney U test was used to statistically analyze if there was any significant difference in the expression of Senescence marker protein-30 between oral lichen planus, oral lichenoid reaction and non-specific inflammation. Even though a greater expression was seen in the oral lichen planus cases than oral lichenoid reaction, the difference in both the epithelium and connective tissue was not statistically significant. Conclusion: This study shows that in addition to the already known mechanisms like apoptosis and increased cell proliferation rates, the activated T-lymphocytes may also trigger a senescent change in the cells of oral lichen planus. As with the other mechanisms, this is also seen only in a small proportion of the cases.
Aim: This study aimed to evaluate the Ki-67 expression in oral premalignant lesions and normal oral mucosa. Materials and Methods: The cases were selected on the basis of the details obtained from the patients. A total of 45 specimens were divided into three groups: Group 1 (normal mucosa), Group 2 (clinically and histologically diagnosed as oral lichen planus), and Group 3 (clinically and histologically diagnosed as leukoplakia). Specimens were prepared and the slides for Ki-67 were observed under light microscope with a magnification of ×400. The tissue samples were thoroughly examined, and the pattern of expression was analyzed semiquantitatively by counting the number of positive cells. Results: The mean positive cell count of normal mucosa was 23.20 ± 2.89, of oral lichen planus was 42.82 ± 2.65, and of leukoplakia was 82.14 ± 3.10. There was a statistically significant difference of expression observed between the groups ( P < 0.001). On multiple comparisons using Tukey post hoc test, a statistical difference was found between all the three groups. Conclusion: Ki-67 is an easily applicable marker of cell proliferation whose expression correlates well with the disease progression.
Résumé Objectif : Comparer les prises en charge observées en 1999 et en 2004, établir un bilan de la situation épidémiologique du cancer du sein en Aquitaine en 2004. Méthodes : Enquête descriptive transversale par sondage aléatoire incluant les patientes admises en affection de longue durée pour un cancer du sein en 2004. Résultats : L’incidence brute annuelle a progressé de 126 à 159 cas pour 100 000 femmes. Le taux des tumeurs in situ était de 10,6 % ± 2,1, celui des tumeurs infiltrantes de 89,4 % ± 2,1. Le taux des tumeurs invasives de taille inférieure ou égale à 10 mm était de 23,1 % (9,6 % en 1999). Les comptes-rendus anatomopathologiques étaient mieux renseignés, notamment pour les facteurs prédictifs de récidive. Certains écarts persistaient : nombre de ganglions examinés lors d’un curage axillaire inférieur à 10 pour 28,7 %, prescription trop fréquente des marqueurs tumoraux plasmatiques (40,1 %). La technique du ganglion sentinelle s’était développée (24,8 % des traitements chirurgicaux). Exceptés 15 prélèvements ganglionnaires non justifiés, les pratiques concernant les cancers in situ étaient conformes aux référentiels. Conclusion : L’incidence médico-administrative du cancer du sein a augmenté depuis cinq ans en Aquitaine. Une amélioration de la prise en charge des patientes a été constatée mais certains écarts aux référentiels persistaient. Ces constats soulignent l’intérêt de ces évaluations régionales menées en partenariat avec un groupe d’experts. En dressant un état des lieux des prises en charge, elles permettent aux professionnels de poursuivre la réflexion sur les pratiques. Prat Organ Soins 2010;41(1):11-21
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