Assessment of Toxicological Effect of Shogaol in Albino Mice

Abstract

Systemic studies dealing with 6-Shogaol (C17H24O3) safety in experimental animals is lacking. Therefore, the aim of current study was to determine the safe dose of 6-Shogaol that can be used in mice model and to assess the potential toxicity that may be initiated by the higher concentrations of this substance by means of clinical observations and evaluation of histopathological changes in liver, kidney and spleen. Sixty mice were divided into 6 groups; groups 1 and 2 served as negative and vehicle control respectively, whereas animals of groups 3, 4, 5 and 6 were treated with 10, 20, 40, and 100 mg/kg b.w. Shogaol respectively. The animals were investigated daily for any sign indicative for activity alterations and toxicity along with their body weight measurement throughout experiment for 14 days. At the end of the experiment, the animals were euthanized and the liver, spleen and kidney were collected for histopathological examination. The results obtained from this study showed that the 10, 20 and 40 mg/kg b.w. doses of Shogaol were safe compared to the 100 mg/kg b.w. dose which resulted in mild clinical activity alterations, reduction in body weight gain and histopathological changes, probably attributed to Shogoal toxicity, in 30% of the total mice treated by this dose. No mortality was observed in all groups. These results may provide a new insight into the safe doses of this phenolic constituent of ginger in experimental animals and open the way for more future studies related to its medicinal benefits.

Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review

“…Consequently, ginger is considered a carrier of potential anti-diabetic and neuroprotective molecules [ 101 ]. Fortunately, another study showed that shogaol had no adverse clinical effects on mice at dosages of 10, 20, and 40 mg/kg BW [ 102 ]. Since COVID-19 is associated with an overproduction of ROS through high oxidative stress, ginger constitutes a potential tool for reducing the stress on the cells, therefore lowering further complications.…”

Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review

“…No mortality was observed at any dose, and only mild clinical changes were observed at doses of 100 mg/kg. 33 The recommended doses of ginger range from 200 mg to 2.5 g per day of the dried extract, containing between 1% to 4% shogaols. 34 Side effects include mainly GIT symptoms, and there may be potentiation of anticoagulant effects.…”

Is 6-Shogaol a Beneficial Phytochemical for Patients with Lower-Risk Myelodysplastic Syndrome? A Narrative Review

“…In a systematic review of 109 randomised controlled trials, Anh et al (2020) found that most adverse effects were GIT related, namely heartburn, nausea, diarrhoea, abdominal pain, bloating, gas and epigastric distress. Moreover, doses ranging from 10 mg/kg to 100 mg/kg of 6-shogaol were administered for 14 days to albino mice (Hassan & Hassan, 2018). No mortality was observed at any dose, and only mild clinical changes were observed at doses of 100 mg/kg.…”