Assessment of TNF-a, IL-17, IL-33, TGF-b, and Dopamine in Iraq Depressed Women with Chronic Toxoplasmosis Infection

shaker, Maha mahmood; Alabassi, Hazima Mossa; Rahman, Sabah A. Hameid A.

doi:10.5958/0976-5506.2019.03190.5

Cited by 2 publications

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“…However, the levels of both hormones remained in the normal range. Similarly, in Iraq, reported a significant increase in T3 and T4 levels in depressed women infected with T. gondii than healthy controls, T3 and T4 levels remained in the normal range [32]. However, raissi etal., [35] in Iran, reported non-significant differences in T3 and T4 levels between hypothyroidism group, hyperthyroidism group and control group in correlation with T. gondii seropositivity.…”

Section: Association Between Latent Toxoplasmosis and Thyroid Hormone...mentioning

confidence: 95%

“…On the contrary, another study in Iraq reported a significantly higher levels of TSH in T. gondii infected women with depression than healthy control. The authors think this increase in TSH level might be due to TSHR-antibodies, which bind to TSH receptors in the thyroid gland and subsequently lead to increased TSH levels in serum [32]. In the present study, this negative association between TSH and IgG or normal levels of TSH can be interpreted as follows; that T. gondii has no effect on thyroid function, and the parasite is unable to infect the hypothalamus in most people, or it could be due to the effect of antipsychotic medications, which have been proven to interfere with thyroid hormone levels [33] and inhibit replication of T. gondii [34].…”

Section: Association Between Latent Toxoplasmosis and Thyroid Hormone...mentioning

confidence: 99%

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Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

Mohammed¹,

Mageed²

2022

GSC Biol. Pharm. Sci.

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Latent toxoplasmosis is a prevalent chronic infection caused by a protozoan parasite called Toxoplasma gondii. Recent studies have shown that T. gondii may affect thyroid hormone levels and thus induce behavioral alteration. However, this correlation has been inadequately investigated. Therefore, we aimed to examine the relationship between latent toxoplasmosis and thyroid hormone levels in schizophrenic patients. For this purpose, blood samples and sociodemographic information were collected from 101 schizophrenic patients attending three psychiatric hospitals in Kurdistan region of Iraq. Anti-T. gondii-IgG antibodies and thyroid hormones levels (TSH, T3, T4) were determined in sera of all patients using ELISA technique. Anti-T. gondii-IgG antibodies were detected in sera of 40 (39.6%) out of 101 schizophrenic patients. Logistic regression analysis showed significant association between toxoplasmosis and schizophrenic patients in 50-60 age group (OR=6.177, p=0.05), and un-employed patients (OR=3.562, p=0.05). Data analysis showed non-significant difference in TSH levels between IgG seropositive and IgG seronegative group (p>0.05). On the other hand, T4 levels were significantly higher in the seropositive (10.16 ± 2.61) than seronegative group (7.01 ± 2.01), with highly significant positive correlation between IgG and T4 levels (p= 0.001). Finally, T3 levels were significantly higher in the seropositive (1.91 ± 0.5) than seronegative group (1.12 ± 0.43), with non-significant positive correlation between IgG and T3 levels (p=0.30). Owing to the fact that there was statistically significant increase in thyroid hormone levels in T. gondii seropositive patients, our results suggest that there is a significant association between toxoplasmosis and thyroid hormone levels in schizophrenic patients.

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Section: Association Between Latent Toxoplasmosis and Thyroid Hormone...mentioning

confidence: 95%

Section: Association Between Latent Toxoplasmosis and Thyroid Hormone...mentioning

confidence: 99%

Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

Mohammed¹,

Mageed²

2022

GSC Biol. Pharm. Sci.

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show abstract

The level of interleukin-17, 23, and gamma interferon in cutaneous leishmaniasis patients before and after intra lesion treatment

et al. 2022

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Assessment of TNF-a, IL-17, IL-33, TGF-b, and Dopamine in Iraq Depressed Women with Chronic Toxoplasmosis Infection

Cited by 2 publications

References 0 publications

Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

Correlation between latent toxoplasmosis and thyroid hormone levels in sera of schizophrenic patients

The level of interleukin-17, 23, and gamma interferon in cutaneous leishmaniasis patients before and after intra lesion treatment

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