Assessment of the use of vitamin C and E supplements concomitantly to antibiotic treatment against Helicobacter pylori : A systematic review and meta-analysis

Caicedo, Yaset; Moreno, Cesar; Fandiño, Yardany Rafael Méndez; Fonseca, Sofía; Motta, Héctor Fabio Cortes; Guerra, Santiago

doi:10.1016/j.medcle.2018.05.016

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…However, this analysis included only three studies. Although Ochoa et al ( 79 ) also conducted a meta-analysis on a similar topic in 2018, there were errors and shortcomings in the data extraction and chart construction. Moreover, the above two articles only performed intention-to-treat analyses of the data.…”

Section: Discussionmentioning

confidence: 99%

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Cai

Jin

et al. 2022

Front. Nutr.

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BackgroundOver recent decades, epidemiological studies have shown relationships between vitamins and Helicobacter pylori (H. pylori) infection and eradication, but the results are controversial.MethodsA comprehensive meta-analysis and systematic review were conducted to clarify the relationships between common types of vitamins and H. pylori. We applied meta-regression, subgroup analysis and sensitivity analysis to obtain available evidence. Articles published from January 1991 to June 2021 in PubMed, EMBASE, and the Cochrane Library were searched.ResultsIn total, we identified 48 studies. The results indicate that H. pylori -positive patients had lower serum vitamin B12 [standardized mean difference (SMD) = −0.30; 95% confidence interval (CI): −0.53 – −0.08], folate (SMD = −0.69; 95% CI: −1.34 – −0.04), vitamin C (SMD = −0.37; 95%CI: −0.57 – −0.18) and vitamin D (SMD = −0.34; 95% CI: −0.49 – −0.18) levels than H. pylori-negative patients. Patients in which H. pylori had been successfully eradicated had higher serum vitamin D levels (SMD = 1.37; 95% CI: 0.37–2.38) than in patients in which eradication had been unsuccessful. The serum vitamin B12 levels of H. pylori-positive patients improved after successful H. pylori eradication therapy (SMD = 1.85; 95% CI: 0.81–2.90), and antioxidant vitamin supplementation to an H. pylori eradication regimen improved the eradication rate (risk ratio = 1.22; 95% CI: 1.02–1.44 for per-protocol analysis; risk ratio = 1.25; 95% CI: 1.06–1.47 for intention-to-treat analysis).ConclusionsH. pylori infections decrease the serum levels of several types of vitamins, eradication of H. pylori could rescue its adverse effects, and antioxidant vitamin supplementation may improve the H. pylori eradication rate.Systematic Review Registrationidentifier: CRD42021268127.

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Section: Discussionmentioning

confidence: 99%

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Cai

Jin

et al. 2022

Front. Nutr.

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“…Vitamin D and the vitamin D receptor may trigger immune responses and contribute to the anti-H. pylori activity when combined (52,53). In a meta-analysis study in which 10 studies investigating the effectiveness of vitamin C and / or E supplements in the treatment of H.pylori infection of Ochoa et al were evaluated, it was found that these vitamin supplements did not have a significant effect on bacterial eradication (54).…”

Section: Vitamin Ementioning

confidence: 99%

“…However, it was not proven that vitamin C has a significant effect on H. pylori treatment in these studies. Ochoa et alof H. pylori in a meta-analysis study in which 10 studies investigating the effectiveness of vitamin C and/or E supplements in the H.pylori infection treatment of Ochoa et al were evaluated, it was found that these vitamin supplements did not have a significant effect on bacterial eradication (54). In contrast, it has been found that ascorbic acid levels are low in gastric fluids of gastritis patients (58).…”

Section: Fruit Consumptionmentioning

confidence: 99%

Nutrition and Helicobacter pylori infection in gastric disease

Selma İrem SÖZEN,

Hafize Kovancı,

Muhammed Said Dalkılıç

et al. 2023

World J. Adv. Res. Rev.

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H. pylori is a highly prevalent bacterial infection among humans. It is considered the major etiological factor in the development of chronic gastritis, peptic ulcers, and stomach cancer. Nutritional therapy is important for the prevention of gastritis, as well as for reducing stomach irritation (irritation) in the treatment of gastritis, and it plays an important role by helping to eradicate or strengthen the stomach wall. Chronic gastritis should be diagnosed before it progresses and causes fatal diseases such as peptic ulcer or cancer, and it should be treated with both a healthy diet and appropriate medications.

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“…The co-supplementation of vitamin E and C exhibits an additive activity because vitamin C can deoxide vitamin E after the oxidation of vitamin E during deoxidation of ROS, and accordingly, a few pieces of research indicated the benefit of antioxidant intake during H. pylori eradication ( Table 2 ) [ 171 – 173 ]. On the contrary, several studies declined the beneficial effect of vitamin C and E administration on H. pylori eradication rate [ 174 , 175 ]. Chuang et al concluded that vitamin C and E supplementation not only has no inhibitory activity against H. pylori but also may reduce the efficiency of metronidazole-based therapy in patients infected with metronidazole-susceptible strains [ 176 ].…”

Section: H Pylori and Vitaminsmentioning

confidence: 99%

The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System

Nabavi-Rad

Azizi

Jamshidizadeh

et al. 2022

Journal of Immunology Research

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Helicobacter pylori as a class I carcinogen is correlated with a variety of severe gastroduodenal diseases; therefore, H. pylori eradication has become a priority to prevent gastric carcinogenesis. However, due to the emergence and spread of multidrug and single drug resistance mechanisms in H. pylori, as well as serious side effects of currently used antibiotic interventions, achieving successful H. pylori eradication has become exceedingly difficult. Recent studies expressed the intention of seeking novel strategies to improve H. pylori management and reduce the risk of H. pylori-associated intestinal and extragastrointestinal disorders. For which, vitamin supplementation has been demonstrated in many studies to have a tight interaction with H. pylori infection, either directly through the regulation of the host inflammatory pathways or indirectly by promoting the host immune response. On the other hand, H. pylori infection is reported to result in micronutrient malabsorption or deficiency. Furthermore, serum levels of particular micronutrients, especially vitamin D, are inversely correlated to the risk of H. pylori infection and eradication failure. Accordingly, vitamin supplementation might increase the efficiency of H. pylori eradication and reduce the risk of drug-related adverse effects. Therefore, this review aims at highlighting the regulatory role of micronutrients in H. pylori-induced host immune response and their potential capacity, as intrinsic antioxidants, for reducing oxidative stress and inflammation. We also discuss the uncovered mechanisms underlying the molecular and serological interactions between micronutrients and H. pylori infection to present a perspective for innovative in vitro investigations, as well as novel clinical implications.

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Assessment of the use of vitamin C and E supplements concomitantly to antibiotic treatment against Helicobacter pylori : A systematic review and meta-analysis

Cited by 6 publications

References 37 publications

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Nutrition and Helicobacter pylori infection in gastric disease

The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System

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