Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Cai, Xianlei; Li, Xueying; Jin, Yangli; Zhang, Miaozun; Xu, Yuan; Liang, Chao; Weng, Yihui; Yu, Weiming; Li, Xiuyang

doi:10.3389/fnut.2021.781333

Cited by 15 publications

(12 citation statements)

References 80 publications

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“…Also, one of the Meta-analyses (consisting of 48 studies) demonstrated the association of the vitamins (e.g., vitamin D) and H. pylori . The results of this Meta-analysis suggested that the H. pylori positive patients had lower serum vitamin D levels than H. pylori negative patients ( 25 ). Both the factors, i.e., Dengue fever and H. pylori , lower the vitamin D levels in patients.…”

Section: Introductionmentioning

confidence: 90%

Vitamin D deficiency in dengue fever patients' coinfected with H. pylori in Pakistan. A case-control study

Mirza

Zhang²,

Zhang³

et al. 2022

Front. Public Health

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IntroductionDengue fever is a vector-borne disease with an estimate of 390 million persons getting the infection each year with a significant public health impact. It has been reported DENV patients with vitamin D deficiency led to severe form of dengue infection; while H. pylori coinfection alters vitamin D receptors leading to vitamin D deficiency. We hypothesize that DENV patient's having low vitamin D along with H. pylori coinfection could have worsen dengue severity as well as vitamin D deficiency. In this case-control study, we compared (I) the vitamin D deficiency in dengue fever cases with or without H. pylori coinfection, and (II) negative dengue fever as a control with or without H. pylori coinfection. We have also assessed the correlation between vitamin D levels and its effect on warning signs of the dengue fever. Further, we have investigated whether coinfection with H. pylori has any effect on warning signs in the dengue fever patients and the vitamin D deficiency in all serotypes of the dengue virus infected patients.MethodsIn this case control study the association of the vitamin D levels with age, gender and H. pylori coinfection in dengue fever hospitalized patients was assessed using chi-square and multivariate logistic regression analysis.ResultsFour hundred dengue fever patients with H. pylori coinfection were compared with 400 dengue negative controls with H. pylori coinfection. The mean age was 29.96 ± 10.5 and 29.88 ± 10.7 years among cases and controls, respectively. Most dengue fever patients with H. pylori coinfection were deficient in vitamin D compared with negative dengue controls with H. pylori coinfection. In multivariate logistic regression, the dengue cases with H. pylori coinfection were.056 times (95% CI: 0.024, 0.128, P = 0.000) more likely to have vitamin D “deficiency', while compared with the cases who did not have H. pylori coinfection.ConclusionThe present study proposes that vitamin D deficiency in dengue fever patients coinfected with H. pylori is much higher than the dengue fever negative controls coinfected with H. pylori. As hypothesized the DENV patient with H. pylori coinfection has vitamin D deficiency as well as increased dengue severity.

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Section: Introductionmentioning

confidence: 90%

Vitamin D deficiency in dengue fever patients' coinfected with H. pylori in Pakistan. A case-control study

Mirza

Zhang²,

Zhang³

et al. 2022

Front. Public Health

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“…However, after H. pylori eradication, the malnutrition in vitamin B12 levels could be restored (SMD = 1.85; 95% CI: 0.81–2.90). Although studies summarizing changes in the levels of vitamin A, C, and E in relation to H. pylori eradication success or failure are limited, interventions involving antioxidant vitamins C and E have shown significant improvements in the H. pylori eradication rate (relative risk (RR) = 1.25; 95% CI: 1.06–1.47), 38 while the impact of vitamin A remains unclear.…”

Section: Metabolic Pathways Alterationsmentioning

confidence: 99%

“…A comprehensive analysis of the NHANES III database revealed an inverse correlation between vitamin D deficiency (defined as levels lower than 20 ng/mL) and H. pylori CagA seropositivity. In a recent meta-analysis comprising 48 studies conducted in 2022, it was demonstrated that successful eradication of H. pylori was associated with higher serum vitamin D levels (standardized mean difference (SMD) = 1.37; 95% CI: 0.37-2.38), 38 while vitamin D deficiency was more prevalent in patients with treatment failure compared to successful treatment (70% vs. 30%). 39,40 Studies using mouse models have shown that oral supplementation of Vitamin D3 can reduce the rate of H. pylori colonization by upregulating key adherence markers such as CAMP expression in the gastric mucosa.…”

Section: Vitamin Metabolismmentioning

confidence: 99%

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Ye,

Feng,

et al. 2023

Helicobacter

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The microbiota actively and extensively participates in the regulation of human metabolism, playing a crucial role in the development of metabolic diseases. Helicobacter pylori (H. pylori), when colonizing gastric epithelial cells, not only induces local tissue inflammation or malignant transformation but also leads to systemic and partial changes in host metabolism. These shifts can be mediated through direct contact, toxic components, or indirect immune responses. Consequently, they influence various molecular metabolic events that impact nutritional status and iron absorption in the host. Unraveling the intricate and diverse molecular interaction links between H. pylori and human metabolism modulation is essential for understanding pathogenesis mechanisms and developing targeted treatments for related diseases. However, significant challenges persist in comprehensively understanding the complex association networks among H. pylori itself, the infected host's status, the host microbiome, and the immune response. Previous metabolomics research has indicated that H. pylori infection and eradication may selectively shape the metabolite and microbial profiles of gastric lesions. Yet, it remains largely unknown how these diverse metabolic pathways, including isovaleric acid, cholesterol, fatty acids, and phospholipids, specifically modulate gastric carcinogenesis or affect the host's serum metabolism, consequently leading to the development of metabolic‐associated diseases. The direct contribution of H. pylori to metabolisms still lacks conclusive evidence. In this review, we summarize recent advances in clinical evidence highlighting associations between chronic H. pylori infection and metabolic diseases, as well as its potential molecular regulatory patterns.

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“…Vitamin C is an essential nutrient in humans and is involved in the regulation of a number of biological mechanisms, including iron metabolism, collagen and carnitine synthesis, catabolism of tyrosine and demethylation of proteins, DNA and RNA, and it also exerts both antioxidant and pro-oxidant activity at micromolar and millimolar concentrations, respectively [ 8 ]. Vitamin C might have antineoplastic effects in the stomach by reducing oxidative stress and subsequent cellular and DNA damage [ 9 ], inhibiting the formation of N-nitroso compounds and other carcinogens [ 10 , 11 ], and potentially interfering with Helicobacter pylori infection, which is recognized as the main risk factor for GC [ 6 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project

Sassano,

Seyyedsalehi,

Collatuzzo

et al. 2024

Gastric Cancer

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Background Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC. Methods Fourteen case–control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose–response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials. Results Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose–response analysis showed decreasing ORs of GC up to 150–200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0. Conclusions The findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).

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Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Cited by 15 publications

References 80 publications

Vitamin D deficiency in dengue fever patients' coinfected with H. pylori in Pakistan. A case-control study

Vitamin D deficiency in dengue fever patients' coinfected with H. pylori in Pakistan. A case-control study

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project

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