Assessment of the Subclinical Irritation of Surfactants: A Screening Open Assay Model

Zhai, Hongbo; Fautz, Rolf; Fuchs, Anne; Branco, Nara; Maibach, Howard I.

doi:10.1159/000068799

Cited by 10 publications

(13 citation statements)

References 15 publications

(22 reference statements)

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“…A number of physicochemical interactions exist between corneocytes and surfactants. [19] One of the earliest events following surfactant-induced protein denaturation is perceived as corneocyte swelling. [20] This condition leads to a paradoxical and transient stratum corneum hydration following surfactant challenge.…”

Section: Surfactant-induced Reactionsmentioning

confidence: 99%

The Skin Landscape Following Nonoptical Capacitance Imaging

Xhauflaire-Uhoda

Pierard

Quatresooz

2010

American Journal of Clinical Dermatology

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Skin capacitance is an electrical property measurable at the level of the stratum corneum. Values are related to the moisture content of the tissue. Using the silicon image sensor technology, it has recently become possible to measure capacitance at 50 microm intervals on the skin surface. The resulting nonoptical picture corresponds to skin capacitance imaging. This novel tool for dermatologists highlights with precision the hollow skin surface patterns, including dermatoglyphics, the patterns of the shallow skin lines, and wrinkles. The topographic heterogeneity in skin surface hydration is made visible. In addition, the sweat gland and follicular openings are disclosed. Skin disorders induced by surfactants or presenting as hyperkeratotic areas, including some neoplasms, may show typical aspects. It is concluded that skin capacitance imaging brings added value to the clinical assessment performed by dermatologists.

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Section: Surfactant-induced Reactionsmentioning

confidence: 99%

The Skin Landscape Following Nonoptical Capacitance Imaging

Xhauflaire-Uhoda

Pierard

Quatresooz

2010

American Journal of Clinical Dermatology

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“…In particular, the apparent SC dehydration can be assessed in vivo using devices measuring some electrical properties of skin at different frequencies and at different depths inside the SC [2, 3, 4, 5, 6, 7]. The impaired desquamation can be conveniently measured by squamometry [8, 9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Silicon Image Sensor Technology for in vivo Detection of Surfactant-Induced Corneocyte Swelling and Drying

2005

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Background: Several instrumental methods can indirectly assess some specific aspects of cutaneous irritation at the level of the stratum corneum (SC). Objective: There is a need for developing more sensitive approaches in this field. Methods: We assessed a recently introduced innovative tool (SkinChip^®) based on capacitive pixel-sensing technology in its potential to detect early discrete manifestations of skin irritation. The sensor generates a detailed non-optical picture corresponding to a capacitance map of the skin surface reaching 50 µm pixel resolution. Some topographical details can be easily disclosed and the SC hydration as well. Two surfactant solutions were tested on volunteers. These solutions were applied under test patches for 2 days on the volar forearms. Clinical and SkinChip assessments were performed 3 h after removing the patch. Results: The generated images allowed a precise observation of skin irritation which appeared as a two-step process. Early changes consisted of darker pixels corresponding to overhydrated swollen corneocytes at the irritated sites. Two days later, the same area appeared as white pixels, indicating the loss of corneocyte hydration. Conclusion: The SkinChip device appears to be a very sensitive tool for detecting the early steps of surfactant-induced skin irritation affecting the SC.

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“…As a result, they help in exfoliating superficial corneocytes. In addition, the structure and physical properties of the SC can be altered profoundly, particularly following prolonged contact with anionic surfactants [2,3]. In such circumstances, the skin barrier function is weakened, the transepidermal water loss increases and the electrical properties of the SC are impaired [4,5].…”

Section: Introductionmentioning

confidence: 99%

Comparative Clinical and Electrometric Assessments of the Impact of Surfactants on Forearm Skin

Uhoda

Paye²,

Pierard

2003

Exog Dermatol

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Surfactant-based skin care products can induce minimal to severer alterations of the human stratum corneum (SC). These changes can be conveniently assessed using electrometric devices. Four different surfactant-based solutions were applied to the forearms of 10 healthy volunteers following a soap chamber test method. The 2-day patch testing was followed by a 2-week follow-up. Clinical and instrumental assessments were performed at 7 time points. Data generated by the Corneometer^® CM820, the Dermalab Moisture Module^® and the Nova Dermal Phase Meter^® (DPM) 9003 were compared. The significant differences between the product aggressiveness to the SC were similarly disclosed by the Corneometer and the Dermalab Moisture Module. The ranking of product aggressiveness given by the 3 devices 5 days after patch removal was similar to that given by the clinical assessment of erythema. A high level of correlation was found between the values yielded by the immediate and continuous mode assessments using the Dermalab Moisture Module with the pin probe, while the correlation was weaker with the Nova DPM. This finding may be related to the fact that the Nova DPM is influenced by the accumulation of the transepidermal water loss in the continuous mode assessment while there is no significant occlusion effect of the Dermalab Moisture pin probe that is more representative of the initial level of SC hydration. In conclusion, the Corneometer and the Dermalab Moisture Module respond similarly to changes in the SC content. This finding is different from some previous reports.

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Assessment of the Subclinical Irritation of Surfactants: A Screening Open Assay Model

Cited by 10 publications

References 15 publications

The Skin Landscape Following Nonoptical Capacitance Imaging

The Skin Landscape Following Nonoptical Capacitance Imaging

Silicon Image Sensor Technology for in vivo Detection of Surfactant-Induced Corneocyte Swelling and Drying

Comparative Clinical and Electrometric Assessments of the Impact of Surfactants on Forearm Skin

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