Assessment of the nickel-albumin binding assay for diagnosis of acute coronary syndrome

Silva, Sandra Huber da; Pereira, Renata da Silva; Hausen, Bruna dos Santos; Signor, Cristiane; Gomes, Patrícia; Campos, Marli Matiko Anraku de; Moresco, Rafael Noal

doi:10.1515/cclm.2011.063

Cited by 9 publications

(9 citation statements)

References 35 publications

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“…Other studies on human serum albumin have utilised Cu 2+ and Ni 2+ instead of Co 2+ to assess reduced metal binding. In some cases, these studies were inspired by the originally proposed mechanism involving binding to the NTS [134] , [135] , [136] . Even though Cu 2+ and Ni 2+ do indeed preferentially bind to the N-terminus, these studies were successful in demonstrating poor binding capacity of albumin for these ions in coronary artery syndromes – similar to the ACB assay [134] , [135] , [136] .…”

Section: Proposed Alternatives To the Acb Assaymentioning

confidence: 99%

“…In some cases, these studies were inspired by the originally proposed mechanism involving binding to the NTS [134] , [135] , [136] . Even though Cu 2+ and Ni 2+ do indeed preferentially bind to the N-terminus, these studies were successful in demonstrating poor binding capacity of albumin for these ions in coronary artery syndromes – similar to the ACB assay [134] , [135] , [136] . It should however be considered that site A is a potent secondary binding site for these metal ions once the NTS is saturated, as explained in Section 2 [34] , [137] , [138] .…”

Section: Proposed Alternatives To the Acb Assaymentioning

confidence: 99%

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Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding

Coverdale

Katundu

Sobczak

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Proposed Alternatives To the Acb Assaymentioning

confidence: 99%

Section: Proposed Alternatives To the Acb Assaymentioning

confidence: 99%

Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding

Coverdale

Katundu

Sobczak

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…This assay involved such steps as ACB; only CoCl 2 is replaced by an equivalent amount of nickel sulfate. The authors of this method found a significant correlation between ACB and NAB revealing their low specificity, with the sensitivity of NAB higher than ABC's [49]. Although this method correlated well with the ACB assay, its clinical applications must still be verified.…”

Section: Methods For Measuring імаmentioning

confidence: 95%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

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“…In the Microwells assay, the DTT has been replaced with a stable azo dye chromogen. An automated method to measure ischemia induced alterations of the binding capacity of HSA for nickel [27] has been described [46].…”

Section: Non Ischemicmentioning

confidence: 99%