2020
DOI: 10.1080/07391102.2020.1724567
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Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies

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Cited by 7 publications
(6 citation statements)
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References 81 publications
(4 reference statements)
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“…Finally, these results are in agreement with the studies conducted respectively on the seed cotyledon and leaves of Chrysophyllum albidum at doses between 250 and 1000 mg/kg bw [48,49] on the one hand, and on the other hand on Bixin (10 mg/kg bw) extracted from the seeds of Bixa orellana [50]. These authors have shown that these extracts significantly decrease the glucose level in normal and diabetic rats induced by alloxane.…”
Section: Discussionsupporting
confidence: 90%
“…Finally, these results are in agreement with the studies conducted respectively on the seed cotyledon and leaves of Chrysophyllum albidum at doses between 250 and 1000 mg/kg bw [48,49] on the one hand, and on the other hand on Bixin (10 mg/kg bw) extracted from the seeds of Bixa orellana [50]. These authors have shown that these extracts significantly decrease the glucose level in normal and diabetic rats induced by alloxane.…”
Section: Discussionsupporting
confidence: 90%
“…Several studies have demonstrated the beneficial effects of medicinal plants in reducing blood glucose level using different models of diabetes induction in animals [2,23,25]. In the present study, we chose alloxan monohydrate to induce diabetes as it has been widely used in the recent years to develop stable hyperglycemia in experimental animal model of diabetes [18,19].…”
Section: Discussionmentioning
confidence: 99%
“…Diabetic group exhibited a continuous decrease in body weight over a period of 21 days. The decrease of body weight could be due to insulin deficiency or abnormalities in the catabolism of macronutrients such as fat and protein leading to extreme tissue protein loss and muscle wastage [23,48]. The oral administration of H. sabdariffa extract and Glibenclamide in alloxan-induced diabetic rats for 3 weeks increased the body weight, which indicates a better control of high blood glucose in these rats.…”
Section: Discussionmentioning
confidence: 99%
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“…Bixin also shows in silico selectivity on peroxisome proliferator-activated receptors (PPARs), particularly by the peroxisome proliferatoractivated receptor gamma (PPARγ), which supports the hypoglycemic activity of Bixin. 22…”
Section: Hypoglycemic Activitymentioning
confidence: 99%