Assessment of the effect of Maytenus ilicifolia (espinheira santa) extract on the labeling of red blood cells and plasma proteins with technetium-99m

Oliveira, Juliana Ferreira de; Braga, A. C.S.; Oliveira, Mariana Borges; Ávila, A. S.R.; Caldeira-de-Araújo, Adriano; Cardoso, Valbert Nascimento; Bezerra, Roberto J.A.C.; Bernardo-Filho, Mário

doi:10.1016/s0378-8741(00)00240-3

Cited by 38 publications

(2 citation statements)

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“…These results could be explained by possible oxidant and cytotoxic in vitro properties of the chemical compounds present in OZE solution (Schmalz et al, 2000). These compounds could oxidize the stannous ions that are necessary for the reduction of the pertechnetate ion, as suggested by other authors with regard to several natural products, including Maytemus icilifolia (Oliveira et al, 2000), Ginkgo biloba (Moreno et al, 2002), Paullinia cupana , and Mentha crispa (Santos-Filho et al, 2004). Another possible explanation would be due to the physiological/pharmacological properties of the OZE in the RBC membrane.…”

Section: Discussionmentioning

confidence: 83%

Zinc-oxide-eugenol alters labeling of blood constituents with technetium-99m and shape of red blood cells

et al. 2008

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Samples of blood incubated with OZE, stannous chloride, and 99m Tc were isolated and fractions were separated. Radioactivity of the blood constituents decreased significantly (p \ 0.05) due to the OZE. Morphological alterations were also found. Although rats were utilized in these experiments, precaution is MEDICINAL CHEMISTRY RESEARCH recommended in the interpretation of nuclear-medicine examinations in patients that have been treated with OZE in dentistry procedures.

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Section: Discussionmentioning

confidence: 83%

Zinc-oxide-eugenol alters labeling of blood constituents with technetium-99m and shape of red blood cells

et al. 2008

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“…In addition, medicinal plants have polyphenols that are micronutrients with antioxidant activity. On the other hand, RBC labeling procedure with radiopharmaceuticals such as 99 mTc depends on the presence of stannous (+2) ions (40). Antioxidant property of medicinal plants can block the action of stannous ions, antioxidant action impeding or decreasing the stannous ion oxidization and binding to them in labeling and fixation procedure; so decreasing the binding of radiopharmaceuticals in plasma proteins (23,71).…”

Section: Resultsmentioning

confidence: 99%

Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

2019

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Radiopharmaceuticals are drugs that contain radioisotopes used for diagnostic and therapeutic purposes. There are evidences that medicinal herbs and their constituents can modify the radiolabeling, biodistribution, and pharmacokinetics of radiopharmaceuticals through drug interaction. To have an overview of the effects and the underlying mechanisms of medicinal plants on the radiolabeling and bioavailability of radiopharmaceuticals, we conducted this study to summarize the current findings in this field. The scientific literature was systematically collected from databases and analyzed. Studies showed that medicinal plants and their constituents can alter radiolabeling and biodistribution via several mechanisms. Interactions with proteins in red blood cells at the same sites, chelating action of stannous and pertechnetate ions, antioxidant action impeding or decreasing stannous ion oxidation, direct oxidation of stannous ions, generation of reactive oxygen species (ROS) which oxidize stannous ions and damage induced in the cell membrane. Most the medicinal plants can decrease the radioactivity of radiopharmaceuticals, but some of them like Peumus boldus, Punica granatum, Nectandra membranacea, Mentha crispa, Rosmarinus officinalis and derivatives such as eugenol and epigallocatechin gallate have increasing effects. In addition, altering feature in some of them is tissue dependent.

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Effect of ginkgo biloba on the in vitro labeling of red blood cells and plasma proteins with technetium‐99M

Moreno

Feliciano

Freitas

et al. 2001

Labelled Comp Radiopharmac

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Ginkgo biloba is the phytoterapic most used in popular medicine in the treatment of inflammation, free-radical with traumatic brain injury and Afzheimer's dementia. Red blood cells (RBC) labeled with technetium-99m (Tc-99m) are used for several evaluations in nuclear medicine. This labeling depends on a reducing agent, usually the stannous ion. Any drug which alters the labeling of the tracer could be expected to modify the disposition of the radiopharmaceutical. We have evaluated the influence of the Ginkgo biloba extract on the labeling of RBC and plasma proteins with Tc-99m. Blood was withdrawn and incubated with Ginkgo biloba extract (0; 0.004; 0.04; 9.4; 4 and 20 mg/mL). Stannous chloride (1.2 pl/mL) was added and, then, Tc-99m was added. Plasma (P) and blood cells (RBC) were isolated, also precipitated with trichloroacetic acid and soluble (SF) and insoluble fractions (IF) separated. The analysis of the results shows that there is a decrease in the radioactivity (fiom 97.7 5 0.7 to 49.5 5 3.9%) in RBC with the drug (4mg/mL). In the labeling process of RBC with Tc-99m, the stannous and pertechnetate ions pass though the membrane, so, we suggest that the Ginkgo biloba effect can be explained by (i) an inhibition of the transport of these ions, (ii) damage in membrane, (iii) competition with the cited ions for the same binding sites, or (iv) possible generation of reactive oxygen species that could oxidize the stannous ion.

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Assessment of the effect of Maytenus ilicifolia (espinheira santa) extract on the labeling of red blood cells and plasma proteins with technetium-99m

Cited by 38 publications

References 11 publications

Zinc-oxide-eugenol alters labeling of blood constituents with technetium-99m and shape of red blood cells

Zinc-oxide-eugenol alters labeling of blood constituents with technetium-99m and shape of red blood cells

Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

Effect of ginkgo biloba on the in vitro labeling of red blood cells and plasma proteins with technetium‐99M

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