Assessment of the cytotoxicity of aluminium oxide nanoparticles on selected mammalian cells

Radziun, E.; Wilczyńska, Jadwiga Dudkiewicz; Ksiazek, Iza; Nowak, Karolina; Anuszewska, Elżbieta; Kunicki, A.; Olszyna, A.; Ząbkowski, Tomasz

doi:10.1016/j.tiv.2011.07.010

Cited by 125 publications

(86 citation statements)

References 22 publications

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“…Mammalian cells were treated with 10-400 μg/mL aluminium nanoparticles to examine the toxic effects. The observed results suggested that no significant toxicity was observed on cell viability in the study [133]. In another study cell viability was determined with respect to the interaction of human bone marrow derived mesenchymal stem cells (HMSC) with aluminium nanoparticles in the range 25-40 μg/mL.…”

Section: Effects On Cell Linesmentioning

confidence: 95%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Effects On Cell Linesmentioning

confidence: 95%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…No significant effect on cell phagocytosis was observed with Al 2 O 3 nanoparticles (alveolar macrophages of NR8383) [20]. Results [21] show the ability of aluminum oxide nanoparticles to penetrate through the membranes of L929 and BJ cells. Despite this, there was no significant increase in apoptosis or decrease in cell viability observed, suggesting that aluminum oxide nanoparticles in the tested range of concentrations has no cytotoxic effects on the selected mammalian cells.…”

Section: Introductionmentioning

confidence: 85%

Antitumor activity of low-dimensional alumina structures

Коровин¹,

Фоменко²

2016

AIP Conference Proceedings

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Abstract. Nano-dimensional materials have recently attracted much attention with respect to their potential role in medicine. Physical mechanisms of interaction of nanoparticles with tumor cells will help to develop new methods for cancer disease treatment. Based on aluminum oxide phases, positively charged low-dimensional structures have different shape: agglomerates of nanosheets, nameplates, cone-shaped nanoaggregates were synthesized with the help of aluminum nanoparticles. The cytotoxicity effect of these low-dimensional structures on A549, HeLa, MDA, PyMT tumor cells was studied. It was shown that agglomerates of nanosheets were more toxic for investigating cell lines. Agglomerates of nanosheets had a medium toxic effect at a concentration of 10 mg/ml while nameplates and cone-shaped nanoaggregates were nontoxic. The toxic effect of agglomerates of nanosheets correlates with their shape, mainly the presence of multiple edges.

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“…These investigators employed EZ4U assay technique (cell proliferation and cytotoxicity) instead of MTT (a colorimetric assay for assessing cell metabolic activity) for cell viability assessment. It was found that AlONPs, at concentrations of 10, 50, 100, 200, and 400 μg.ml -1 had no significant toxic effect on the viability of mammalian cells [13]. The result of a study by Kim et al in which mouse lymphoma cells line was used, showed that aluminum oxide NPs (<50 nm) cause genotoxic effects in the form of DNA damage without any mutagenic effects [14].…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

An Overview of Nanotoxicology

Sezgin¹,

Eniş²,

Öztürk³

et al. 2017

NWSA

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Nanotechnology grows rapidly and has potential applications in many areas such as industry, agriculture, business, medicine etc. Since nanomaterials are used in daily life activities nowadays, research on the toxicity of nanoparticles gains more importance. Nanoparticles (NPs) have been studied for cell toxicity, immunotoxicity, and genotoxicity. This review reports a summary of recent researches on the toxicity of nanomaterials having different classes: metals and non-metals.

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Assessment of the cytotoxicity of aluminium oxide nanoparticles on selected mammalian cells

Cited by 125 publications

References 22 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

Antitumor activity of low-dimensional alumina structures

An Overview of Nanotoxicology

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